ID   G3HYB2_CRIGR            Unreviewed;       262 AA.
AC   G3HYB2;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 51.
DE   RecName: Full=Sepiapterin reductase {ECO:0000256|ARBA:ARBA00019170};
DE            EC=1.1.1.153 {ECO:0000256|ARBA:ARBA00013075};
GN   ORFNames=I79_016036 {ECO:0000313|EMBL:EGW02924.1};
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW02924.1, ECO:0000313|Proteomes:UP000001075};
RN   [1] {ECO:0000313|Proteomes:UP000001075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX   PubMed=21804562; DOI=10.1038/nbt.1932;
RA   Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA   Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA   Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA   Famili I., Palsson B.O., Wang J.;
RT   "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL   Nat. Biotechnol. 29:735-741(2011).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the sepiapterin reductase family.
CC       {ECO:0000256|ARBA:ARBA00010483}.
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DR   EMBL; JH000918; EGW02924.1; -; Genomic_DNA.
DR   RefSeq; XP_007628595.1; XM_007630405.2.
DR   AlphaFoldDB; G3HYB2; -.
DR   STRING; 10029.G3HYB2; -.
DR   PaxDb; 10029-XP_007628595-1; -.
DR   eggNOG; KOG1204; Eukaryota.
DR   InParanoid; G3HYB2; -.
DR   OMA; DMFTRTF; -.
DR   Proteomes; UP000001075; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004757; F:sepiapterin reductase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006729; P:tetrahydrobiopterin biosynthetic process; IEA:InterPro.
DR   CDD; cd05367; SPR-like_SDR_c; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR002347; SDR_fam.
DR   InterPro; IPR006393; Sepiapterin_red.
DR   NCBIfam; TIGR01500; sepiapter_red; 1.
DR   PANTHER; PTHR44085; SEPIAPTERIN REDUCTASE; 1.
DR   PANTHER; PTHR44085:SF2; SEPIAPTERIN REDUCTASE; 1.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   NADP {ECO:0000256|ARBA:ARBA00022857};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001075}.
SQ   SEQUENCE   262 AA;  28075 MW;  9F2D7484176B90CC CRC64;
     MEEGGLGCTV CVLTGASRGF GRALAPLLAR LLSPGSVLLL SARSDLALLQ LEEELCTQHP
     GLRVLRAAAD LGTEAGVQQL LCTVRKLPRP EGLQRLLLIN NAGTLGDISK GFLDVSDPAE
     VNNYWALNLT SMLCLTSGTL NAFPDSPGLS KTVVNISSLC ALEPFKGWGL YCAGKAARDM
     LYQVLAAEEP SVRVLSYAPG PLDTDMQQLA RETSKDPELR TRLQELKSKG KLVDCGSSAQ
     KLLTLLQKNT FQSGAHIDFY DS
//