ID G3HYT4_CRIGR Unreviewed; 1563 AA.
AC G3HYT4;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 59.
DE RecName: Full=RBR-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012251};
DE EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
GN ORFNames=I79_016226 {ECO:0000313|EMBL:EGW09324.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW09324.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the RBR family. Ariadne subfamily.
CC {ECO:0000256|ARBA:ARBA00005884}.
CC -!- SIMILARITY: Belongs to the cullin family. {ECO:0000256|PROSITE-
CC ProRule:PRU00330, ECO:0000256|RuleBase:RU003829}.
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DR EMBL; JH000944; EGW09324.1; -; Genomic_DNA.
DR STRING; 10029.G3HYT4; -.
DR PaxDb; 10029-XP_007647139-1; -.
DR eggNOG; KOG1815; Eukaryota.
DR InParanoid; G3HYT4; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR CDD; cd20347; BRcat_RBR_CUL9; 1.
DR CDD; cd20359; Rcat_RBR_CUL9; 1.
DR Gene3D; 1.20.120.1750; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR004939; APC_su10/DOC_dom.
DR InterPro; IPR048962; ARIH1-like_UBL.
DR InterPro; IPR047561; BRcat_RBR_CUL9.
DR InterPro; IPR045093; Cullin.
DR InterPro; IPR016158; Cullin_homology.
DR InterPro; IPR036317; Cullin_homology_sf.
DR InterPro; IPR001373; Cullin_N.
DR InterPro; IPR019559; Cullin_neddylation_domain.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR047560; Rcat_RBR_CUL9.
DR InterPro; IPR044066; TRIAD_supradom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR22771; CULLIN AND GALACTOSE-BINDING DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR22771:SF2; CULLIN-9; 1.
DR Pfam; PF03256; ANAPC10; 1.
DR Pfam; PF21235; ARI1_UBAl; 1.
DR Pfam; PF00888; Cullin; 1.
DR Pfam; PF01485; IBR; 2.
DR SMART; SM01337; APC10; 1.
DR SMART; SM00884; Cullin_Nedd8; 1.
DR SMART; SM00647; IBR; 2.
DR SUPFAM; SSF75632; Cullin homology domain; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF57850; RING/U-box; 3.
DR PROSITE; PS50069; CULLIN_2; 1.
DR PROSITE; PS51284; DOC; 1.
DR PROSITE; PS51873; TRIAD; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 234..413
FT /note="DOC"
FT /evidence="ECO:0000259|PROSITE:PS51284"
FT DOMAIN 635..903
FT /note="Cullin family profile"
FT /evidence="ECO:0000259|PROSITE:PS50069"
FT DOMAIN 1114..1331
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS51873"
FT DOMAIN 1284..1327
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 18..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 524..551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 758..777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1490..1563
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 528..551
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1490..1506
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1508..1525
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1563 AA; 176598 MW; CF2F5D7B6EB6C50A CRC64;
MPTTRTILMM LLNRYSEPRG SPERAALESP STQGQDGSPE LLIRSLVGDP SAELFLDLER
VLCCEGSPQG AVRPLLKRLQ QETQPFLLLL RTLDAPGPNR SLLLTVLRVT MRLLDYPEAM
VLPWHEVLEP CLNCLSGPSS DSEIIQELVC FLHRLALTHK DYAVVLCCLG AREVLSKVLD
KHSAQLLLAS ELRDLVTECE KHAQLYSKLT SSILAGCIQM VLGQIEDHRR THQPINIPFF
DVFLRHLCQG SSVEVKEDKC WEKVEVSSNP HRASKLTDRN PKTFWESNGS TGSHSITLYM
HRGVLIRQLT LLVASEDSSY MPARVVVFGG DSVSCINTEL NTVNVMPSAS RVVLLENLNR
FWPIIQIRIK RCQQGGIDTR VRGVEVLGPK PTFWPLFREQ LCRRTCLFYT IRAQAWSQDI
AEDRQRLLQL CPRLNRVLRH EQNFADRFLP DDEAAQALGK TCWEALVSPL VQNITSPDAE
SVSSLGWLLD QYLERRESVQ SSQSQAPSFA SRVRRLCHLL VHVEPPPGSS PESSTQLFGK
NSKSQNGSPV LSPVLPSSSL RNITQCWLSV VQEQVSRFLA AAWRASDFVP RYCSLYERLQ
RAGLELFGPR AAFTVALRSG FSGALLQQSF LTATHMSEQF ARHIDQQIQG GLLGGASGVA
MLGHLQQYLE PITVLSGLEL ATTFEHFYQH YMADRLLSLG SSWLEGAVLE QIGLCFPNRL
PQLMLQSLHT SEELQRQFHV YQLRQLDRQL LEQEDQEEWR LEEVEEEDKG QETEKEILKE
DPGPEVSVLV LSPRCWPVSP LCYLHNPRQH LPTEFCDALD RFSSFYSHSQ NYPVLNMGPH
RRLQWTWLGW AELQFGDQTL HVSTVQMWLL LTFNQTEEVS VESLLKTSGL SPELLHQALL
PLIEDSGPLT LEEAQNLPQA GMLRLREPRS QPLEEVLWLI PPQTYFSVEK DEGRTLEQKR
NLLSCLLVRI LKAHGEKGLH IDQLVCLVLE AWKKGPNPPG SLGRTVSGGV ACSSTDVLSC
ILHLLGQGYV ERRDDRPQLP AGRTMSPQEV EGLMEQTVQQ VQETLNLEPD VARHLLAHSH
WGTEQLLQSY SDDPEPLLLA AGLRVPQAQV VPTRPDHCPV CVSPLGPNDD APSLCCLHCC
CKSCWNEYLT TRIEQNFVLN CTCPIADCPA QPTGAFIRDI VSSPEVISKY EKALLRAYVE
SCSNLTWCTN PQGCDRILCR QGLGSGTTCS KCGWASCFNC SFPEAHYPAS CGHMSQWVDD
GGYYEGMSVE AQSKHLAKLI SKRCPSCQAP IEKNEGCLHM TCARCNHGFC WRCLKSWKPS
HKDYYNCSAM VSKAARQEKR FQDYNERCTF HHQAREFAVN LRNQASAIHE VPPPKSFTFL
HDACRALEQA RKVLAYACVY SFYSQDTEYM DVVEQQTENL ELHTNALQIL LEESLLRCQD
LASSLRFLRA DCLSTGTELL RRIQERLLAI LQHSTQDFRV GLQSPSVEVR EVKGSNVPSN
QPQGSLGLEA EEEEEEEEDV PEWHHDFDEE LDNDSFSYDE ESENLDRETF FFGDEDDDDE
SYD
//
