ID G3I1X3_CRIGR Unreviewed; 636 AA.
AC G3I1X3;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Ski oncogene {ECO:0000256|ARBA:ARBA00022369};
DE AltName: Full=Proto-oncogene c-Ski {ECO:0000256|ARBA:ARBA00032146};
GN ORFNames=I79_017402 {ECO:0000313|EMBL:EGW00349.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW00349.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
CC -!- SIMILARITY: Belongs to the SKI family. {ECO:0000256|ARBA:ARBA00009513}.
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DR EMBL; JH001100; EGW00349.1; -; Genomic_DNA.
DR AlphaFoldDB; G3I1X3; -.
DR STRING; 10029.G3I1X3; -.
DR PaxDb; 10029-XP_007606906-1; -.
DR eggNOG; ENOG502QTF6; Eukaryota.
DR InParanoid; G3I1X3; -.
DR OMA; PPGRCKK; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0046332; F:SMAD binding; IEA:InterPro.
DR CDD; cd21083; DHD_Ski; 1.
DR Gene3D; 3.10.390.10; SAND domain-like; 1.
DR Gene3D; 3.10.260.20; Ski; 1.
DR InterPro; IPR014890; c-SKI_SMAD4-bd_dom.
DR InterPro; IPR047315; DHD_Ski.
DR InterPro; IPR009061; DNA-bd_dom_put_sf.
DR InterPro; IPR010919; SAND-like_dom_sf.
DR InterPro; IPR003380; SKI/SNO/DAC.
DR InterPro; IPR037000; Ski_DNA-bd_sf.
DR InterPro; IPR023216; Tscrpt_reg_SKI_SnoN.
DR PANTHER; PTHR10005:SF15; SKI ONCOGENE; 1.
DR PANTHER; PTHR10005; SKI ONCOGENE-RELATED; 1.
DR Pfam; PF08782; c-SKI_SMAD_bind; 1.
DR Pfam; PF02437; Ski_Sno; 1.
DR SMART; SM01046; c-SKI_SMAD_bind; 1.
DR SUPFAM; SSF46955; Putative DNA-binding domain; 1.
DR SUPFAM; SSF63763; SAND domain-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001075}.
FT DOMAIN 126..221
FT /note="c-SKI SMAD4-binding"
FT /evidence="ECO:0000259|SMART:SM01046"
FT REGION 230..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 361..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 612..636
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..263
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 399..423
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 636 AA; 71047 MW; A25C3E3D8D9F94F5 CRC64;
MPSDRSTERC ETVLEGETIS CFVVGGEKRL CLPQILNSVL RDFSLQQINS VCDELHIYCS
RCTADQLEIL KVMGILPFSA PSCGLITKTD AERLCNALLY GGAYPPPCKK ELAASLALGL
ELSERSVRVY HECFGKCKGL LVPELYSSPS AACIQCLDCR LMYPPHKFVV HSHKALENRT
CHWGFDSANW RAYILLSQDY TGKEEQARLG RCLDDVKEKF DYANKYKRRV PRVSEPPASI
RPKADDTSSQ SPASSEKDKQ STWLRTLAGS SNKSLGCPHP RQRLSAFRPW SPAVSASEKE
TSSHLPALIR DSFYSYKSFE TAVAPNVALA PPTQQKVVNS PPCTTVVSRA PEPLTTCIQP
RKRKLTMETP GAPDMLTSVA APEEDKDSEA EVEVESREEF TSSLSSLSSP SFTSSSSAKD
LSSPGMHAQP VAGPDATVHA DAPSGLEAEL EHLRQALEGG LDTKEAKEKF LHEVVKMRVK
QEEKLTAALQ AKRSLHQELE FLRVAKKEKL REATEAKRSL RKEIERLRAE NEKKMKEANE
SRVRLKRELE QARQVRVCDK GCEAGRLRAK YSAQIEDLQA KLQHAEADRE QLRADLLRER
EAREHLEKVV KELQEQLWPR PRPENVGGEG SAELDP
//
