ID G3I3U3_CRIGR Unreviewed; 3383 AA.
AC G3I3U3;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Lysosomal-trafficking regulator {ECO:0000313|EMBL:EGW00901.1};
GN ORFNames=I79_018112 {ECO:0000313|EMBL:EGW00901.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW00901.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
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DR EMBL; JH001212; EGW00901.1; -; Genomic_DNA.
DR STRING; 10029.G3I3U3; -.
DR eggNOG; KOG1786; Eukaryota.
DR InParanoid; G3I3U3; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF163; LYSOSOMAL-TRAFFICKING REGULATOR; 1.
DR Pfam; PF02138; Beach; 2.
DR Pfam; PF14844; PH_BEACH; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 2688..2794
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2799..3033
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 3194..3228
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 142..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1164..1194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2022..2059
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2350..2375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1170..1184
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2031..2055
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2350..2365
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3383 AA; 380094 MW; 097EF4007679BAEC CRC64;
MSTDSNSLAR EFLIDVNQLC NAVVQKVEAR EEEEEETHMA TLGQYLVHGR GFLLLTKLNS
IIDQALTCRE ELLTLLLSLL PLVWKIPVQE QQATDFNLPL SSNIILTKEK NSSLQKSTQG
KLYLEGSAPP GPVSAKVNLF RKSRQQRKST HRYSVRDARK TQLSTSDSEG NSDEKSTVVS
KHRRSHVLPR LLTQSPKEDH LIAKLDPSET KELVLSDAMA LENSREIIPR QDSNGDILSE
PAALSILSNM NNSPFDLCHV LLSLLEKVCK FDIALNHNSS LATSVVPTLT EFLAGFGDCC
NQSDTLERQV VSSGWSEEPV ALVQRMLFRT VLHLMSVDVS TAEAMPESLR KNLTELLRAA
LKIRSCLEKQ PDPFSPRQKK TLQEVQEGFV FSKYRHRALL LPELLEGVLQ LLISCLQSAA
SNPFYFSQAM DLVQEFIQHQ GFNLFETAVL QMEWLLSRDG VPSEATEHLK TLINSVMKIV
STVKKVKSEQ LHHSMCTRKR HRRCEYSHFM QHHRDLSGLL VSAFKNQLSK SPFEETAEGD
VQYPERCCCI AVCAHQCLRL LQQVSLSTTC VQILSGVHSV GICCCMDPKS VIIPLLHAFK
LPALKNFQQH ILNVLNKLLL DQLGGAEISQ RIKKAACNIC TVDSDQLAKL EETLQGTLCG
AGPSSGLPSP SYRFQGILPS SGSEDLLWKW DALEAYQNFV FQEDRLHNIQ IANHICNLIQ
KGNVVVQWKL FNYIFNPVLQ RGVELVHHCQ QLSITSAQTH MCSQLKQCLP QEVLQIYLKT
LPILLKSRTI RDLFLSCNGV NQIIELNYLD GIRSHSLKAF ETLIISLGEQ QKDASVPGVN
GLDMEQELPS LSVSPSLHKQ QASSDSPRSL SKFYASLREA YPKKRKTAHQ DVHINTINLF
LCVAFLCVSK EADSDRDSAN ESEDTSGYDS TTSEPFSHML PCLSLENIVL PSPECLHQAA
DIWSMCRWLY MLSSVFQKQF HRLGGFRVCH ELIFMIIQKL FRSHEEKQGK RQGEVSVNEN
QELIRMSQPE TLKGDVSSSA APELEHLKKN ADSLNELESQ HMFPTSVEQI LSTEAVSGKA
KAFMSQENDT SLQSIRLLES LLAICLHSSR ASQQKMDLEL PPQNLSVENI LCEMKEHLSQ
SKVTETELAK PLFDALLRVA LGNHSADLDP GDNVTEKSHQ SEEEMLSQPG DFSEEIEDSQ
CCNLKLLGEE EGYEADSESN PEDGDIQDDG VELKPEAEGF SASVVPNNLL ENLTHGEIIY
PEICILELNL LSASKAKLDV LAHVFESFLK IARQKEKNIS LLMQQGTVKI LLGGFLNILT
QTNSDFQACQ RVLVDLLVSL MSSRTCSEEL TLLLRIFLEK SPCTEILLVG IQKIVGNDFT
MSPSQYLTFP LLHTPSLSNG VSPQKSPGIL NSKALGLLRR ARISRGKKEA DRESFPSRLL
SSWHIAPIHL PLLGQNCWPH LSEGFSVSLW FNVEYIHESE SATERGKKIK KRNKPSILQD
DSFEGAGAKI GSQEAFYLYA CGPNYTSIMP CKYGKPVIDY SKYINKEILG CEQIRDLFMT
KKGVDVGLLI ESLSVVYTTY CPAQYTIYEP VIRLKGQLKT QLSQRPFSSK EAQSILLEPS
QLKSLRPTEC KTIQGILHEI GGAGVFVFLF ARVVELSGCE ETQALALRVI LSLIKYSQQR
AHELENCNGL SMIHQVLVKQ KCIVGFHILK TLLEGCCGEE VIHINEHGEF KLDVESHAII
QDVKLLQELL LDWKIWNKAE ACVWETLLAA LEVLIRAEHQ QQQFNIKQLL NAHVVHHFLL
TCQVLQEHRE GQLTSLPREV CRSFVKIIAE VLGSPPDLEL LTIIFNFLLA VHPPTNTYVC
HNPTNFYFSL HIDGKIFQEK VQSIMYLRHS SSGGQSFPSP GFLVISPSAF TASPSEGTGS
SNIIPQRMAA QMVRSKSLPE FPTYSPLMQA PKLAGSLGYS IDKLLNVADV QPEKRNPLGS
PCTLKTSKEE AFISSCESAR TVCEMETLLA AQDSVRGVSR GTLGFPMPRV DHRDLGTEPR
SEDDSPVDES YPRRPDNLKG LASFQRSHST IGSLGLAFPS QNGTAAASRW PSLVDRNADD
WENFAFSAAY EANYNRGASA HSVTEDCLIP ICCGLYELLS GVLLILPDAM LEDVMDKIIQ
ADTLLVLVNH PSPAIQQGVI KLLHAYINRA SKEQKDKFLK NRGFSLLANQ LYLHRGTQEL
LECFTEMFFG RRIGLDEEFD LEEVKHMELF QKWSVIPVLG LIETSLYDNV LLHNALLLLL
QVLNSCSKVA DMLLDNGLLY VLCNTVAALN GLEKKFELNY VLVLVDMALV MQLKVLQAAL
EFIRSTANHD SESPVDTVQS PSAHHHTVSQ KRRSIAGPRK FPMAQTESLL MKMRSVASDE
LYTMMQRRMS QEHPSQASEA ELAQRLQRLT ILAVNRIIYQ GSPELAFLPS VQIHKGSMKG
SNKTSGCKQQ WTKIMGSCKE TFRIQLGRLL AHILSPAHTV QERKQIFEIV HEPAHQDILR
DCLSPSPQHG AKLVLYLSEL IHNHQDELNE EELDTAEMLM NALKLCGHKC IPPSAPSKPE
LIKMIKEEQK KYENEESVSK GSWQKTVNNN QQRAVWYDPI YYPTSWQLDP TEGPNRERRR
LQRCYLTIPN KYLLRDRQKS EGVVKPPLSY LFEDKTHSSF SSTVKDKAAS ESIRVNRRCI
SVAPSRETAG ELLLGKCGMY FVEDNASDTV ESTSLQGELE PASFSWTYEE IKEVHRRWWQ
LRDNAVEIFL TNGRTLLLAF DNTKVRDDVY QNILTNNLPN LLEYGNITAL TNLWYTGQIT
NFEYLTHLNK HAGRSFNDLM QYPVFPFILS DYVNETLDLN DPSIYRQYLE EEYRKGARED
DPMPPVQPYH YGSHYSNSGT VLHFLVRMPP FTKMFLAYQG FDFGVRQNGE RVNHVNLPPW
ARNDPRLFIL IHRQALESDH VSQNICHWID LVFGYKQKGK ASVQAINVFH PATYFGMDVS
AVEDPVQRRA LETMIKTYGQ TPRQLFHTAH ASRPGAKLNI EGELPAAVGL LVQFAFRETR
EPIKEITYPP HGERFGSLQA LPTRAICGLS RNFCLLMTYS KEQGVRSMNN TDIQWSAILS
WGYADNILRL KSKQSEPPIN FIQSSQQHQV TSCAWVPDSC QLFTGSKCGV ITAYTNRLTS
STPSEIEMES QMHLYGHTEE ITSLCVCKPY SVMISVSRDG TCIVWDLNRL CYVQSLAGHK
SPVTAVSASE TSGDIATVCD SAGGGSDLRL WTVNGDLVGH VHCREIICSV AFSNQPEGVS
INVIAGGLEN GIVRLWSTWD LKPVREITFP KSNKPIISLT FSCDGHHLYT ANSDGTVIAW
CRKDQQRMKQ PMFYSFLSNY AAG
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