ID G3I6W2_CRIGR Unreviewed; 708 AA.
AC G3I6W2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE RecName: Full=Death domain-associated protein 6 {ECO:0000256|ARBA:ARBA00019298};
DE AltName: Full=Daxx {ECO:0000256|ARBA:ARBA00029641};
GN ORFNames=I79_019240 {ECO:0000313|EMBL:EGW13307.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW13307.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere
CC {ECO:0000256|ARBA:ARBA00004584}. Cytoplasm
CC {ECO:0000256|ARBA:ARBA00004496}. Nucleus, PML body
CC {ECO:0000256|ARBA:ARBA00004322}. Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}. Nucleus, nucleoplasm
CC {ECO:0000256|ARBA:ARBA00004642}.
CC -!- SIMILARITY: Belongs to the DAXX family.
CC {ECO:0000256|ARBA:ARBA00008592}.
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DR EMBL; JH001393; EGW13307.1; -; Genomic_DNA.
DR RefSeq; XP_003510877.1; XM_003510829.3.
DR RefSeq; XP_016835345.1; XM_016979856.1.
DR RefSeq; XP_016835346.1; XM_016979857.1.
DR AlphaFoldDB; G3I6W2; -.
DR STRING; 10029.G3I6W2; -.
DR PaxDb; 10029-XP_007623246-1; -.
DR GeneID; 100774618; -.
DR CTD; 1616; -.
DR eggNOG; ENOG502QRS6; Eukaryota.
DR InParanoid; G3I6W2; -.
DR OrthoDB; 2920075at2759; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
DR GO; GO:0042393; F:histone binding; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProt.
DR CDD; cd13151; DAXX_helical_bundle; 1.
DR CDD; cd13150; DAXX_histone_binding; 1.
DR Gene3D; 1.20.58.2170; -; 1.
DR Gene3D; 1.10.8.810; Daxx helical bundle domain; 1.
DR InterPro; IPR046378; DAXX_histone-bd.
DR InterPro; IPR046426; DAXX_histone-bd_sf.
DR InterPro; IPR031333; Daxx_N.
DR InterPro; IPR038298; Daxx_N_sf.
DR PANTHER; PTHR12766:SF9; DEATH DOMAIN-ASSOCIATED PROTEIN 6; 1.
DR PANTHER; PTHR12766; DEATH DOMAIN-ASSOCIATED PROTEIN 6 DAXX; 1.
DR Pfam; PF03344; Daxx; 1.
DR Pfam; PF20920; DAXX_hist_bd; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 49..145
FT /note="Daxx N-terminal Rassf1C-interacting"
FT /evidence="ECO:0000259|Pfam:PF03344"
FT DOMAIN 296..380
FT /note="Daxx histone-binding"
FT /evidence="ECO:0000259|Pfam:PF20920"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 143..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 398..691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 144..182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 399..430
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 433..469
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 490..511
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 541..566
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 567..601
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 602..622
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 623..672
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 708 AA; 78293 MW; A59B451D948358E1 CRC64;
MASADSIIVL DDDDEDEAAA QAGPSQLPSS PVSPGPEASG PSESHGNGRS RNSGGRKCYK
LENERLFEEF LELCKVQTSD HPEVVPFLHK QQQRAQSLFL ASAEFCNIMS RVLSRARNRP
AKLYVYINEL CTVLKAHSNK KKLNLAPAPS TPSKPSGDNP PTESSSELTN AENTASKASR
TRGSRRQIQR LEQLLALYVA EIRRLQEKEL DLSELDDPDS TYLQEARLKR KLIHLFGRLC
ELKDCSSLTG RVIEQRIPYR GTRYPEVNRR IERLINKPGP DAFPDYGDVL RAVERAATRH
NLGLPRQQLQ LMAQDAFRDV GVRLQERRHL DLIYNFGCHL TDDYKPGFDP ALSDPTLARR
LRENRSLAMS RLDEVISKYA MMQDKSEEGE RQKRRARLLG NTSHSSGSPK VSLDSGEGPS
GLASQECPTT SRADTDDDEE SEEEEEEEEE EEEEEEEVTE DEDEDLERLQ QDEGGAGEEE
GGGGADSEGD KSPSRSNSQG EQQNKGLSET AASPDPHSVD AESSGEQPEE PFLEEESPLS
HSFQLEIEDK DTTPCLEEKD ISSSRKQSED SLPTVLENGA DVVTSTSFNG RVSSHTWQDS
GPPCKRSRKE KKLLDSEPLE NSNVEKQKAQ QGNGKNVWTP PTGSSPVADS STRVDSPSHG
LVTSSLCSPF PSLTSPTPQP QSPQPCSYKM SVATQCDPEE IIVLSDSD
//