ID G3IFA4_CRIGR Unreviewed; 1488 AA.
AC G3IFA4;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Multiple epidermal growth factor-like domains 6 {ECO:0000313|EMBL:EGW04058.1};
GN ORFNames=I79_022425 {ECO:0000313|EMBL:EGW04058.1};
OS Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Cricetulus.
OX NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW04058.1, ECO:0000313|Proteomes:UP000001075};
RN [1] {ECO:0000313|Proteomes:UP000001075}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX PubMed=21804562; DOI=10.1038/nbt.1932;
RA Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA Famili I., Palsson B.O., Wang J.;
RT "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL Nat. Biotechnol. 29:735-741(2011).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; JH002354; EGW04058.1; -; Genomic_DNA.
DR STRING; 10029.G3IFA4; -.
DR PaxDb; 10029-XP_007606824-1; -.
DR eggNOG; KOG4497; Eukaryota.
DR InParanoid; G3IFA4; -.
DR Proteomes; UP000001075; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR Gene3D; 2.10.25.10; Laminin; 7.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 7.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR24035:SF109; INTEGRIN BETA-LIKE PROTEIN A-RELATED; 1.
DR PANTHER; PTHR24035; MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN; 1.
DR Pfam; PF07645; EGF_CA; 3.
DR Pfam; PF14670; FXa_inhibition; 2.
DR Pfam; PF00053; Laminin_EGF; 5.
DR Pfam; PF00400; WD40; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 27.
DR SMART; SM00179; EGF_CA; 6.
DR SMART; SM00180; EGF_Lam; 20.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 3.
DR PROSITE; PS00022; EGF_1; 17.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 12.
DR PROSITE; PS01187; EGF_CA; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 218..258
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 313..353
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 544..580
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 588..623
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 863..893
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 945..980
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1031..1066
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1074..1109
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1117..1152
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1246..1281
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1294..1324
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1332..1367
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 570..579
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 613..622
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 883..892
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 970..979
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1056..1065
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1099..1108
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1142..1151
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1271..1280
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1314..1323
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1357..1366
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1488 AA; 156779 MW; D939A3CB736EB55B CRC64;
MSPLQYKVLL YSLDGRLLSA YCAYEWSLGI KSVAWSPSSQ FLAIGSYDGK VRLLNHVTWK
MITEFGHPAA INNPKAVVYK EAEKIPELGL GHLSFPPPRA MAGALSTSES KYEIASGPVS
LQTLKPVADR ANPKMGVGML AFSSDSYFLA TRNDNVPNAV WIWDIQKLKL FVVLEHMSPV
RTFQWDPQQP RLAICTGGSK VYLWSPAGCV SVQVPGEDVD ECRAHNGGCQ HRCVNTPGSY
LCECKPGFRL HTDGRTCLAI SSCTLGNGGC QHLCIQLTVT QHRCQCQPQY QLQEDGRRCV
RYQLAADRKA CEDVDECATG LAQCAHGCLN TQGSFKCVCH AGYELGADGR QCYRIEMEIV
NSCEAGNGGC SHGCSHTSTG PLCTCPHGYE LDEDQKTCID IDDCANSPCC QQVCANTPGG
YECSCYAGYR LNTDGCGCED VDECASGHGG CEHHCSNLAG SFQCFCEAGF RLDEDRRGCT
PLEESVVDLD GQLPFVRPLP HIAVLRDELP QLFQDDYGAE EEAAAELRGE HTLTEKFVCL
DHTFGHDCSL TCDDCRNGGT CFPGLDGCDC PAGWTGIICN ETCPPDTFGK NCSSPCICQN
GGTCDPMSGA CRCPPGVRGT HCEDVLTKVL PTGCPKGFYG KHCRKKCHCA NRGRCHRVYG
ACLCDPGLYG RFCHLACPPW AFGPGCSEDC QCEQSHTQSC NPRDGSCSCK AGFRGKHCQE
ECEPGFFGPG CRHRCTCPWG VACNPVSGEC QTQCPPGYQG EDCGQECPVG TFGVNCSGSC
SCVGAPCHRV TGQCLCPPGK TGEDCGADCP EGRWGLGCQE ICPACENGAS CDPEAGACLC
LPGFVGSRCQ EACPAGWFGA GCQMRCACAN DGHCHPATGR CSCSPGWTGL SCQTACDNGH
WGPDCIHPCN CSAGHGSCDA VSGLCLCEAG YEGAQCEQWC RQGYFGPSCE QKCKCEHGAT
CDHVSGACTC PAGWRGSFCE HACPAGFFGL DCGSACNCSA GATCDAVTGS CICPAGRWGP
RCAQSCPSLT YGLNCSQVCT CFNGASCDPI HGQCHCAPGW MGPTCLQACP AGLYGKDCQH
SCLCRNGGSC DPILGQCTCP EGWTGLACEK ECLPGHYGAG CQFSCSCLNG GMCDRLTGHC
LCPAGWTGDK CQSRCPPGRY GPGCEQICKC LNGGSCDIAT GACHCPAGFL GADCSLACPQ
GRFGPSCAHV CACGQGAACD AVSGICICSP GKTGVHCEHG CPQDRFGKNC ELKCACRNGG
LCHATNGSCS CPLGWMGPHC EQACPAGRYG AACLLKCSCQ NNGTCEPTTG ACHCGPGFYG
QACEHSCPPG FYGSGCQGVC ECQQGAPCNP VSGHCLCPAG FHGQFCERGC KPGFFGDSCQ
QQCNCSKNVP CDPISGLCLC PPGRTGATCD LDCRRGRFGP GCALHCDCGG GADCDSISGR
CRCVDNYTGP TCREAPQAQL AEVAGEDLCR RSGHTAILQQ ASGRAMKH
//
