ID   G3IIF4_CRIGR            Unreviewed;       536 AA.
AC   G3IIF4;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   24-JAN-2024, entry version 43.
DE   SubName: Full=Keratin, type II cuticular Hb2 {ECO:0000313|EMBL:EGW05449.1};
GN   ORFNames=I79_023622 {ECO:0000313|EMBL:EGW05449.1};
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW05449.1, ECO:0000313|Proteomes:UP000001075};
RN   [1] {ECO:0000313|Proteomes:UP000001075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX   PubMed=21804562; DOI=10.1038/nbt.1932;
RA   Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W., Xie M.,
RA   Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B., Koh W.,
RA   Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J., Quake S.R.,
RA   Famili I., Palsson B.O., Wang J.;
RT   "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line.";
RL   Nat. Biotechnol. 29:735-741(2011).
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000256|RuleBase:RU000685}.
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DR   EMBL; JH002998; EGW05449.1; -; Genomic_DNA.
DR   AlphaFoldDB; G3IIF4; -.
DR   STRING; 10029.G3IIF4; -.
DR   eggNOG; ENOG502QWIE; Eukaryota.
DR   InParanoid; G3IIF4; -.
DR   Proteomes; UP000001075; Unassembled WGS sequence.
DR   GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 1.20.5.500; Single helix bin; 1.
DR   Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR032444; Keratin_2_head.
DR   InterPro; IPR003054; Keratin_II.
DR   PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR45616:SF12; KERATIN, TYPE II CUTICULAR HB2; 1.
DR   Pfam; PF00038; Filament; 1.
DR   Pfam; PF16208; Keratin_2_head; 1.
DR   PRINTS; PR01276; TYPE2KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW   ECO:0000256|RuleBase:RU000685}; Keratin {ECO:0000256|ARBA:ARBA00022744};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001075}.
FT   DOMAIN          118..449
FT                   /note="IF rod"
FT                   /evidence="ECO:0000259|PROSITE:PS51842"
FT   COILED          234..268
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          334..361
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          393..427
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   536 AA;  59143 MW;  99C7A87C67884041 CRC64;
     MSCRNFQLSS RCGSRSFSSC SAVVPRMVTH YEVSKGPCRP GGAGGLRALG CLGSRSLCNV
     GFGRPRVATR CGMPGFGYRA GAACGPPACI TPVTINESLL VPLELEIDPT VQRVKRDEKE
     QIKCLNNRFA SFINKVRFLE QKNKLLETKW NFMQQQRSCQ SNMEPLFEGY ICALRRQLDC
     VSGDHGRLEA ELCSLQDALE GYKKNLPRDC LAGDEHGYAH IDPGHGFVTV LQDVDTAFLV
     KADLETNLEA LEHEIEFLKA LFEEEISLLQ SQISETSVIV KMDNSRELNV DGIIAEIKAQ
     YDDIASRSKA EAEAWYQSRY EEMRLTAGNH CDNLRNRKNE ILEMNKLIQR LQQDIETVKG
     QVNLPPERRE NHPERCKLEG AIAQAEQQGE AALSDAKCKL AGLEEALQKA KQDMACLLKE
     YQEVMNSKLG LDIEIATYRR LLEGEEHRLC EGIGPVNISV SSSKGAVLYE PCVVGTPMLR
     TEYCMGTTGV LRNSGGCSVV GTGELYIPCE PQGLMGCGSG RSSSMKMGAG SNSCSR
//