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Database: UniProt
Entry: G3IKG6_CRIGR
LinkDB: G3IKG6_CRIGR
Original site: G3IKG6_CRIGR 
ID   G3IKG6_CRIGR            Unreviewed;       386 AA.
AC   G3IKG6;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   25-OCT-2017, entry version 37.
DE   RecName: Full=Triacylglycerol lipase {ECO:0000256|RuleBase:RU362046};
DE            EC=3.1.1.3 {ECO:0000256|RuleBase:RU362046};
DE   AltName: Full=Pancreatic lipase {ECO:0000256|RuleBase:RU362046};
GN   ORFNames=I79_024369 {ECO:0000313|EMBL:EGW09118.1};
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW09118.1, ECO:0000313|Proteomes:UP000001075};
RN   [1] {ECO:0000313|Proteomes:UP000001075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX   PubMed=21804562; DOI=10.1038/nbt.1932;
RA   Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W.,
RA   Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B.,
RA   Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J.,
RA   Quake S.R., Famili I., Palsson B.O., Wang J.;
RT   "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell
RT   line.";
RL   Nat. Biotechnol. 29:735-741(2011).
CC   -!- CATALYTIC ACTIVITY: Triacylglycerol + H(2)O = diacylglycerol + a
CC       carboxylate. {ECO:0000256|RuleBase:RU362046}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU362046,
CC       ECO:0000256|SAAS:SAAS00553472}.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase
CC       family. {ECO:0000256|RuleBase:RU362046,
CC       ECO:0000256|SAAS:SAAS00591292}.
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DR   EMBL; JH003609; EGW09118.1; -; Genomic_DNA.
DR   InParanoid; G3IKG6; -.
DR   Proteomes; UP000001075; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004806; F:triglyceride lipase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   CDD; cd00707; Pancreat_lipase_like; 1.
DR   Gene3D; 2.60.60.20; -; 1.
DR   Gene3D; 3.40.50.1820; -; 2.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR013818; Lipase/vitellogenin.
DR   InterPro; IPR033906; Lipase_N.
DR   InterPro; IPR002331; Lipase_panc.
DR   InterPro; IPR001024; PLAT/LH2_dom.
DR   InterPro; IPR036392; PLAT/LH2_dom_sf.
DR   InterPro; IPR000734; TAG_lipase.
DR   PANTHER; PTHR11610; PTHR11610; 3.
DR   Pfam; PF00151; Lipase; 2.
DR   Pfam; PF01477; PLAT; 1.
DR   PRINTS; PR00823; PANCLIPASE.
DR   PRINTS; PR00821; TAGLIPASE.
DR   SMART; SM00308; LH2; 1.
DR   SUPFAM; SSF49723; SSF49723; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001075};
KW   Disulfide bond {ECO:0000256|RuleBase:RU362046,
KW   ECO:0000256|SAAS:SAAS00709807};
KW   Lipid degradation {ECO:0000256|RuleBase:RU362046};
KW   Lipid metabolism {ECO:0000256|RuleBase:RU362046};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW   Secreted {ECO:0000256|RuleBase:RU362046,
KW   ECO:0000256|SAAS:SAAS00439306}.
FT   DOMAIN      282    386       PLAT. {ECO:0000259|SMART:SM00308}.
SQ   SEQUENCE   386 AA;  43372 MW;  B5C6E26149101FB5 CRC64;
     MPVLCVALSV PGKEVCYERL GCFSNEKPWA GMVQRPLKIL PWSPEDIDTR FLLFTNENPD
     NYQVISATDP ATIEASNFQL DRKTRFIIHG FIDKGEDSWL LDMCKRMFQV EKVNCVCVDW
     RRGAKAEYTQ AAYNTRVVGA EIAYLVQVLS TELEYSPENV HLIGHSLGAH VAGEAGRRLE
     GHLGRITGLD PAEPCFQGLP EEVRLDPSDA MFVDAIHTDS ASIVPYLGTQ NFAACNHLRS
     YKYYASSILN PDGFLGYPCT SYEEFQQNGC FPCPEEGCPK MGHYAEQFEG KTIAVEQTFF
     LNTGDSGNFT RSLKPEAVHV RDIDVDMEVG EIQKVKFLWN NRVINLFRPE MGASQITVQS
     GKDGKEYNFC SNNTVHEDVL QSLYPC
//
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