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Database: UniProt
Entry: G3ILK4_CRIGR
LinkDB: G3ILK4_CRIGR
Original site: G3ILK4_CRIGR 
ID   G3ILK4_CRIGR            Unreviewed;      1406 AA.
AC   G3ILK4;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   25-OCT-2017, entry version 31.
DE   RecName: Full=Voltage-dependent T-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   ORFNames=I79_024772 {ECO:0000313|EMBL:EGW13841.1};
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029 {ECO:0000313|EMBL:EGW13841.1, ECO:0000313|Proteomes:UP000001075};
RN   [1] {ECO:0000313|Proteomes:UP000001075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX   PubMed=21804562; DOI=10.1038/nbt.1932;
RA   Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W.,
RA   Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B.,
RA   Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J.,
RA   Quake S.R., Famili I., Palsson B.O., Wang J.;
RT   "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell
RT   line.";
RL   Nat. Biotechnol. 29:735-741(2011).
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. This channel gives
CC       rise to T-type calcium currents. T-type calcium channels belong to
CC       the "low-voltage activated (LVA)" group and are strongly blocked
CC       by nickel and mibefradil. A particularity of this type of channels
CC       is an opening at quite negative potentials, and a voltage-
CC       dependent inactivation. T-type channels serve pacemaking functions
CC       in both central neurons and cardiac nodal cells and support
CC       calcium signaling in secretory cells and vascular smooth muscle.
CC       They may also be involved in the modulation of firing patterns of
CC       neurons which is important for information processing as well as
CC       in cell growth processes. {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR   EMBL; JH004106; EGW13841.1; -; Genomic_DNA.
DR   InParanoid; G3ILK4; -.
DR   Proteomes; UP000001075; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0008332; F:low voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0070509; P:calcium ion import; IEA:InterPro.
DR   GO; GO:0030317; P:flagellated sperm motility; IEA:InterPro.
DR   GO; GO:0019228; P:neuronal action potential; IEA:InterPro.
DR   InterPro; IPR030162; CACNA1I.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005445; VDCC_T_a1.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF209; PTHR10037:SF209; 3.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01629; TVDCCALPHA1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001075};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     47     71       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    184    205       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    211    236       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    485    508       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    520    541       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    573    595       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    651    673       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    927    949       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    964    992       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1027   1046       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1126   1149       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1205   1222       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1242   1262       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1339   1359       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        9    247       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      439    677       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      887   1159       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1205   1405       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED     1158   1185       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1406 AA;  158927 MW;  889CF10741040CA9 CRC64;
     MVEYSLDLQN INLSAIRTVR VLRPLKAINR VPSMRILVNL LLDTLPMLGN VLLLCFFVFF
     IFGIIGVQLW AGLLRNRCFL EENFTIQGDV ALPPYYQPEE DDEMPFICSL SGDNGIMGCH
     EIPPLKEQGR ECCLSKDDVY DFGAGRQDLN ASGLCVNWNR YYNVCRTGNA NPHKGAINFD
     NIGYAWIVIF QVITLEGWVE IMYYVMDAHS FYNFIYFILL IIVGSFFMIN LCLVVIATQF
     SETKQREHRL MLEQRQRYLS SSTVASYAEP GDCYEEIFQY VCHILRKAKR RALGLYQALQ
     NRRQAMAPGT QAPAKPGPHS KEPSHCKLCP RHSPLDPTPH TLVQPISAIL ASDPSSCPRC
     QHEAGRRPSG MGSMDSGQEG SGSGGSAEGE ADGVGPQSSE DGASSGLEKE EEQEDGAARL
     CGDVWRETRA KLRGIVDSKY FNRGIMMAIL VNTVSMGIEH HEQARSHILC PHIPQPEKLT
     NILEICNVVF TSMFALEMIL KLAAFGLFDY LRNPYNIFDS IIVIISIWEI VGQADGGLSV
     LRTFRLLRVL KLVRFMPALR RQLVVLMKTM DNVATFCMLL MLFIFIFSIL GMHIFGCKFS
     LRTDTGDTVP DRKNFDSLLW AIVTVFQILT QEDWNVVLYN GMASTTPWAS LYFVALMTFG
     NYVLFNLLVA ILVEGFQAEV TISLGSSRSS YYGPWGRSGA GAPRRSSWNS LKHKLPSAEH
     ESLLSGERGG SCAGACEGTR EEAPARIAPL HAPHAHHAHH GPHLAHRHRH HRRTLSLDTR
     DSVDLAELVP VVGAHSRTVW RAPGQAPGHE DCNGRMPNIA KDVFTKMDDR RDRGEDEEEI
     DYTLCFRVRK MIDVYKPDWC EVREDWSVYL FSPENKFRIL CQTIIAHKLF DYVVLAFIFL
     NCITIALERP QIEAGSTERI FLTVSNYIFT AIFVGEMTLK VVSLGLYFGE QAYLRSSWNV
     LDGFLVFVSI IDIVVSVASA GGAKILGVLR VLRLLRTLRP LRVISRAPGL KLVVETLISS
     LKPIGNIVLI CCAFFIIFGI LGVQLFKGKF YHCLGVDTRN ITNRSDCVAA NYRWVHHKYN
     FDNLGQALMS LFVLASKDGW VNIMYNGLDA VAVDQQPVTN HNPWMLLYFI SFLLIVSFFV
     LNMFVGVVVE NFHKCRQHQE AEEARRREEK RLRRLEKKRR KAQRLPYYAT YCPTRLLIHS
     MCTSHYLDIF ITFIICLNVV TMSLEHYNQP TSLETALKYC NYMFTTVFVL EAVLKLVAFG
     LRRFFKDRWN QLDLAIVLLS VMGITLEEIE INAALPINPT IIRIMRVLRI ARGLPLLLLN
     IPRPLAPSLA HLSPQVGNLG LLFMLLFFIY AALGVELFGK LVCNDENPCE GMSRHATFEN
     FGMAFLTLFQ VSTGDNWNGI MKVFMG
//
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