ID G3M6A7_ISOMA Unreviewed; 330 AA.
AC G3M6A7;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Cannabinoid receptor 1 {ECO:0000256|ARBA:ARBA00016934};
DE Flags: Fragment;
GN Name=CNR1 {ECO:0000313|EMBL:AEO94814.1};
OS Isoodon macrourus (Short-nosed bandicoot) (Northern brown bandicoot).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Peramelemorphia; Peramelidae; Isoodon.
OX NCBI_TaxID=37698 {ECO:0000313|EMBL:AEO94814.1};
RN [1] {ECO:0000313|EMBL:AEO94814.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21940861; DOI=10.1126/science.1211028;
RA Meredith R.W., Janecka J.E., Gatesy J., Ryder O.A., Fisher C.A.,
RA Teeling E.C., Goodbla A., Eizirik E., Simao T.L., Stadler T., Rabosky D.L.,
RA Honeycutt R.L., Flynn J.J., Ingram C.M., Steiner C., Williams T.L.,
RA Robinson T.J., Burk-Herrick A., Westerman M., Ayoub N.A., Springer M.S.,
RA Murphy W.J.;
RT "Impacts of the Cretaceous Terrestrial Revolution and KPg extinction on
RT mammal diversification.";
RL Science 334:521-524(2011).
RN [2] {ECO:0000313|EMBL:AEO94814.1}
RP NUCLEOTIDE SEQUENCE.
RA Meredith R., Janecka J., Gatesy J., Ryder O., Fisher C., Teeling E.,
RA Goodbla A., Eizirik E., Simao T., Stadler T., Rabosky D., Honeycutt R.,
RA Flynn J., Ingram C., Steiner C., Williams T., Robinson T., Burk A.,
RA Westerman M., Ayoub N., Springer M., Murphy W.;
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Cell
CC projection, axon {ECO:0000256|ARBA:ARBA00004489}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion outer membrane
CC {ECO:0000256|ARBA:ARBA00004294}. Presynapse
CC {ECO:0000256|ARBA:ARBA00034106}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR EMBL; JN633136; AEO94814.1; -; Genomic_DNA.
DR AlphaFoldDB; G3M6A7; -.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0098793; C:presynapse; IEA:UniProtKB-SubCell.
DR GO; GO:0004949; F:cannabinoid receptor activity; IEA:InterPro.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000810; Canbinoid_rcpt_1.
DR InterPro; IPR002230; Cnbnoid_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR22750:SF47; CANNABINOID RECEPTOR 1; 1.
DR PANTHER; PTHR22750; G-PROTEIN COUPLED RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00522; CANABINOID1R.
DR PRINTS; PR00362; CANNABINOIDR.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00022787};
KW Receptor {ECO:0000256|RuleBase:RU000688, ECO:0000313|EMBL:AEO94814.1};
KW Transducer {ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 65..89
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 101..123
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 135..160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 181..203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 223..247
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 293..313
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 81..330
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AEO94814.1"
FT NON_TER 330
FT /evidence="ECO:0000313|EMBL:AEO94814.1"
SQ SEQUENCE 330 AA; 37397 MW; C75458D9911784FB CRC64;
FRGSPFQEKM TVGDNPQLIP SDQINITEFY NNKSLSSYKD EDNIQCGENF MDMECFMILN
PSQQLAIAVL SLTLGTFTVL ENLLVLCVIL HSRSLRCRPS YHFIGSLAVA DLLGSVIFVY
SFVDFHVFHR KDSPNVFLFK LGGVTASFTA SVGSLFLTAI DRYISIHRPL AYKRIVTRPK
AVVAFCVMWT IAIVIAVLPL LGWNCKKLQS VCSDIFPLID ETYLMFWIGV TSILLLFIVY
AYVYILWKAH SHAVRMIQRG TQKSIIIHTS EDGKVQVTRP DQTRMDIRLA KTLVLILVVL
IICWGPLLAI MVYDVFGKMN KLIKTVFAFC
//
