ID G3MYZ2_BOVIN Unreviewed; 416 AA.
AC G3MYZ2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=HtrA serine peptidase 3 {ECO:0000313|Ensembl:ENSBTAP00000054781.2};
GN Name=HTRA3 {ECO:0000313|Ensembl:ENSBTAP00000054781.2,
GN ECO:0000313|VGNC:VGNC:59337};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000054781.2, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000054781.2, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000054781.2,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000054781.2}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000054781.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase S1C family.
CC {ECO:0000256|ARBA:ARBA00010541}.
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DR AlphaFoldDB; G3MYZ2; -.
DR SMR; G3MYZ2; -.
DR STRING; 9913.ENSBTAP00000054781; -.
DR Ensembl; ENSBTAT00000065550.2; ENSBTAP00000054781.2; ENSBTAG00000047613.2.
DR VEuPathDB; HostDB:ENSBTAG00000047613; -.
DR VGNC; VGNC:59337; HTRA3.
DR eggNOG; ENOG502QT3F; Eukaryota.
DR GeneTree; ENSGT00940000159570; -.
DR HOGENOM; CLU_020120_6_2_1; -.
DR InParanoid; G3MYZ2; -.
DR OMA; AYVVTNH; -.
DR TreeFam; TF323480; -.
DR Proteomes; UP000009136; Chromosome 6.
DR Bgee; ENSBTAG00000047613; Expressed in isthmus of fallopian tube and 99 other cell types or tissues.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0030514; P:negative regulation of BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR CDD; cd00987; PDZ_serine_protease; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.40.10.120; -; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR001940; Peptidase_S1C.
DR PANTHER; PTHR22939; SERINE PROTEASE FAMILY S1C HTRA-RELATED; 1.
DR PANTHER; PTHR22939:SF14; SERINE PROTEASE HTRA3; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF13365; Trypsin_2; 1.
DR PRINTS; PR00834; PROTEASES2C.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 348..389
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
SQ SEQUENCE 416 AA; 45421 MW; 50D3DC717190825B CRC64;
MHTREHMHAH THACTNAHTH TCARAHAHTH THTHPAPTRP PSLPSLFYLC LTCLGENLQK
IHKPKQSPHR SASALDATMR SCDVFSCQPV TCLHQLTSPR YKFNFIADVV EKIAPAVVHI
ELFLRHPLFG RNVPLSSGSG FIMSEAGLIV TNAHVVSSTN TVSGRQQLKV QLQNGDTYEA
TIKDIDKKSD IATIKIHPKK KLPALLLGHS ADLRPGEFVV AIGSPFALQN TVTTGIVSTA
QRDGRELGLR DSDMDYIQTD AIINYGNSGG PLVNLDGEVI GINTLKVAAG ISFAIPSDRI
TRFLSEFQDK TGKDWKKRFI GIRMRTITPS LVEELKASNP DFPAVSSGIY VQEVVPNSPS
QRGGIQDGDI IVKVNGRPLA DSSELQEAVL TESPLLLEVR RGNDDLLFSI APEVVL
//
