ID G3MZH7_BOVIN Unreviewed; 495 AA.
AC G3MZH7;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Ectonucleoside triphosphate diphosphohydrolase 2 {ECO:0000313|Ensembl:ENSBTAP00000054974.1};
GN Name=ENTPD2 {ECO:0000313|Ensembl:ENSBTAP00000054974.1,
GN ECO:0000313|VGNC:VGNC:28509};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000054974.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000054974.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000054974.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000054974.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000054974.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC {ECO:0000256|ARBA:ARBA00009283, ECO:0000256|RuleBase:RU003833}.
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DR AlphaFoldDB; G3MZH7; -.
DR SMR; G3MZH7; -.
DR STRING; 9913.ENSBTAP00000054974; -.
DR PaxDb; 9913-ENSBTAP00000054974; -.
DR Ensembl; ENSBTAT00000063714.2; ENSBTAP00000054974.1; ENSBTAG00000048125.2.
DR VEuPathDB; HostDB:ENSBTAG00000048125; -.
DR VGNC; VGNC:28509; ENTPD2.
DR eggNOG; KOG1386; Eukaryota.
DR GeneTree; ENSGT01100000263542; -.
DR HOGENOM; CLU_010246_2_3_1; -.
DR InParanoid; G3MZH7; -.
DR OMA; NEECRYQ; -.
DR TreeFam; TF332859; -.
DR Reactome; R-BTA-8850843; Phosphate bond hydrolysis by NTPDase proteins.
DR Proteomes; UP000009136; Chromosome 11.
DR Bgee; ENSBTAG00000048125; Expressed in parenchyma of mammary gland and 97 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004382; F:GDP phosphatase activity; IBA:GO_Central.
DR GO; GO:0045134; F:UDP phosphatase activity; IBA:GO_Central.
DR GO; GO:0009134; P:nucleoside diphosphate catabolic process; IBA:GO_Central.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR Gene3D; 3.30.420.40; -; 1.
DR Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR InterPro; IPR000407; GDA1_CD39_NTPase.
DR PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1.
DR PANTHER; PTHR11782:SF33; ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 2; 1.
DR Pfam; PF01150; GDA1_CD39; 1.
DR PROSITE; PS01238; GDA1_CD39_NTPASE; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Hydrolase {ECO:0000256|RuleBase:RU003833};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 461..483
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT ACT_SITE 165
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-1"
FT BINDING 204..208
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-2"
SQ SEQUENCE 495 AA; 53901 MW; E9888C8AEDF60159 CRC64;
MAGKALSLLP PLLLAAAGLA GLLLLCVPTR DIREPPALKY GIVLDAGSSH TSMFIYKWPA
DKENDTGIVG QHSSCDAQGG GISSYADNPS GAGQSLVECL NQALRDVPKE RHAGTPLYLG
ATAGMRLLNL TSPEASANVL AAVTQTLTQY PFDFRGARIL SGQDEGVFGW VTANYLLENF
IKYGWVGRWF RPRKGTLGAM DLGGASTQIT FETTSPTEDP ANEVQLRLYG QRYRVYTHSF
LCYGRDQVLR RLLARALQTH GSHPCWPRGY STHVMLWDVY ESPCTAAQRP QAFNRSTRVS
LAGSSDPALC RSLVSQLFNS SSCHFSRCSF NGVFQPPVAG KFIAFSAFFY TMDFLRTVMG
LPVATLQQLE GAVVTLCNQT WSELQARAPD DRARLPDYCA GAMFVQQLLS RGYGFDERSF
GGVTFQKKAG DTAVGWALGY MLNLTNLIPA DPPGLRKGTD FSSWVVLLLL FAAMLLAAFA
LLLHQARSTK SASTI
//
