ID G3N069_BOVIN Unreviewed; 328 AA.
AC G3N069;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Glyoxylate reductase/hydroxypyruvate reductase-like {ECO:0008006|Google:ProtNLM};
GN Name=LOC515578 {ECO:0000313|Ensembl:ENSBTAP00000055226.1};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000055226.1, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000055226.1, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000055226.1,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000055226.1}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000055226.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|RuleBase:RU003719}.
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DR RefSeq; NP_001069187.2; NM_001075719.2.
DR RefSeq; XP_005223985.1; XM_005223928.3.
DR RefSeq; XP_005223986.1; XM_005223929.3.
DR RefSeq; XP_005223987.1; XM_005223930.3.
DR STRING; 9913.ENSBTAP00000055226; -.
DR PaxDb; 9913-ENSBTAP00000055226; -.
DR Ensembl; ENSBTAT00000064509.2; ENSBTAP00000055226.1; ENSBTAG00000036298.3.
DR Ensembl; ENSBTAT00000070425.1; ENSBTAP00000063779.1; ENSBTAG00000036298.3.
DR Ensembl; ENSBTAT00000079609.1; ENSBTAP00000067094.1; ENSBTAG00000036298.3.
DR GeneID; 515578; -.
DR KEGG; bta:515578; -.
DR VEuPathDB; HostDB:ENSBTAG00000036298; -.
DR eggNOG; KOG0069; Eukaryota.
DR GeneTree; ENSGT00940000162740; -.
DR HOGENOM; CLU_019796_1_2_1; -.
DR OMA; TETCDSQ; -.
DR OrthoDB; 6392at2759; -.
DR TreeFam; TF324791; -.
DR Proteomes; UP000009136; Chromosome 24.
DR Bgee; ENSBTAG00000036298; Expressed in liver and 101 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0030267; F:glyoxylate reductase (NADP+) activity; IBA:GO_Central.
DR GO; GO:0016618; F:hydroxypyruvate reductase activity; IBA:GO_Central.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR CDD; cd05301; GDH; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR029753; D-isomer_DH_CS.
DR InterPro; IPR029752; D-isomer_DH_CS1.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10996; 2-HYDROXYACID DEHYDROGENASE-RELATED; 1.
DR PANTHER; PTHR10996:SF286; D-3-PHOSPHOGLYCERATE DEHYDROGENASE 1-RELATED; 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1.
DR PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003719};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 21..325
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 115..294
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 328 AA; 35732 MW; 5B9CD041FBE38384 CRC64;
MGDQDLPGVL VSDLEGPHGI CEDHAEDLKR HFNLITMQDF LENKAQLGPQ IQAVYIWCGR
PAVSQELLHS LPSLKIVASA GAGLDHLDLG LVASFGVKVA NTPHAVSSPT ADLGMALLLA
AARRVVEGHQ LAVSPHTENF PTDYMGQQVT GATLGIIGMG SIGYKIAQRA RAFEMKIVYH
NRKRRKLEEE EAVGAIYCER LDDLLQWSDF VMLAVSLTPQ TQGLIGKREL RLMKPTAILI
NIGRGLLVDQ EALVEALQTG LIKAAALDVT YPEPLPRDHP LLELKNVILT PHIGSATHQA
RRQMMENLVE SILASLSGLP IPNEVLLK
//
