ID G3N1C8_BOVIN Unreviewed; 3221 AA.
AC G3N1C8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Dynein axonemal heavy chain 1 {ECO:0000313|Ensembl:ENSBTAP00000055667.2};
GN Name=DNAH1 {ECO:0000313|Ensembl:ENSBTAP00000055667.2,
GN ECO:0000313|VGNC:VGNC:28122};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000055667.2, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000055667.2, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000055667.2,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000055667.2}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000055667.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC {ECO:0000256|ARBA:ARBA00004230}. Cytoplasm, cytoskeleton, cilium
CC axoneme {ECO:0000256|ARBA:ARBA00004430}.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR SMR; G3N1C8; -.
DR STRING; 9913.ENSBTAP00000055667; -.
DR Ensembl; ENSBTAT00000066095.2; ENSBTAP00000055667.2; ENSBTAG00000047794.2.
DR VEuPathDB; HostDB:ENSBTAG00000047794; -.
DR VGNC; VGNC:28122; DNAH1.
DR eggNOG; KOG3595; Eukaryota.
DR GeneTree; ENSGT00940000154791; -.
DR HOGENOM; CLU_000038_0_0_1; -.
DR InParanoid; G3N1C8; -.
DR OMA; HNVAKMV; -.
DR TreeFam; TF316836; -.
DR Proteomes; UP000009136; Chromosome 22.
DR Bgee; ENSBTAG00000047794; Expressed in retina and 45 other cell types or tissues.
DR ExpressionAtlas; G3N1C8; baseline.
DR GO; GO:0036156; C:inner dynein arm; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0036126; C:sperm flagellum; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IBA:GO_Central.
DR GO; GO:0030317; P:flagellated sperm motility; IBA:GO_Central.
DR GO; GO:0036159; P:inner dynein arm assembly; IEA:Ensembl.
DR GO; GO:0007288; P:sperm axoneme assembly; IEA:Ensembl.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46961:SF18; DYNEIN AXONEMAL HEAVY CHAIN 1; 1.
DR PANTHER; PTHR46961; DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 82..485
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 606..932
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 1430..1511
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 1573..1819
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 1828..2132
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 2159..2380
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 2623..2737
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 2769..2908
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 2914..3217
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT REGION 49..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2048..2108
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2324..2390
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 3221 AA; 366249 MW; C617C7AA00CF4100 CRC64;
ICEEFRSISR KIYEKPNSIE ELAELREWMK GVPEKLVGLE VRRAHWELEE QEDGSQEQGS
GGGQEEQPGP APVLLPLQYD KLSRMVKEFQ PYLDLWTTAS DWLRWSESWM NDPLSAIDAE
QLEKNVIESF KTMHKCVKQF KDIPACQDVA LDIRARIEEF KPYIPLIQGL RNPGMRNRHW
DVLSSEININ VRPKANLTFA RCLEMNLQDH IESISKVAEV AGKEYAIEQA LDKMEKEWST
ILFNVMPYKE TDTYILKSPD EASQLLDDHI VMTQSMSFSP YKKPFEQRIN SWETKLKLTQ
EVLEEWLNCQ RAWLYLEPIF SSEDINRQLP VESKRYQTME RIWRKIMKNA YENREVINVC
SDQRLLDSLR DCNKLLDMVQ KGLSEYLETK RSAFPRFYFL SDDELLEILS QTKDPTAVQP
HLRKCFENIA QVGTWEDLEI THMYSAEGEE VQLSFSIYPS SNVEDWLREV ENSMKASVRD
IIERAIKAYP RMLRTQWVLN WPGQVTIAGC QTYWTLEVEE ALEAGNLSSR LFPHDLVALV
RGSLSRMQRA VLSALIVIEV HAKDVVHKLV QENVVSVHDF EWISQLRYYW MNNNLYIRAV
NAEFIYGYEY LGNSGRLVIT PLTDRCYLTL TGALHLKFGG APAGPAGTGK TETTKDLGKA
LAIQTVVFNC SDQLDFMAMG KFFKGLASAG AWACFDEFNR IDIEVLSVVA QQITTIQKAQ
QQRVERFMFE GVEIPLVPSC AVFITMNPGY AGRTELPDNL KALFRPVAMM VPDYAMIAEI
SLYSFGFNEA NVLAKKITTT FKLSSEQLSS QDHYDFGMRA VKTVISAAGN LKRENPSMDE
ELICLRAIRD VNVPKFLQED LKLFSGIVSD LFPTIKEEET DYGILDKAIR KACEKSNLKD
VDGFLTKCIQ LYETTVVRHG LMLVGPTGSG KSNCYRVLAA AMTSLKGQPS ISGGVYEAVS
YYVLNPKSIT MGQLYGEFDL LTHEWTDGIF SSLIRMGAIT SDTSKKWYMF DGPVDAVWIE
NMNTVLDDNK KLCLSSGEII NSSRQAMTMM FEVQDLAVAS PATVSRCGMV YLEPSILGLM
PFVECWLSRV LCQQPQEWGA HPLQESLAFV RSSVKEVIAS TNSNLTTSLL KLLDCFFKPF
LPKEPRIPGG LFRESPTLCV KQGRGTPIST RSSPSAGPSC PTVQLLALLV HSAWTGTRRG
FRPSLCLLWF QVAWVKWMDS STTFTMMPDT NYCSIIVPTT DTIQMSYLLD MLLTNHKPVS
VLCIGPTGTG KTLTISNKLL KNLPLEYISH FLTFSARTSA NQTQDLIDSK LDKRRKGVFG
PPLGRNFIFF IDDLNMPALE TYGAQPPIEL LRQWMDHGGW YDRKIIGLVD INFVCAMGPP
GGGRNAITPR LTRHFNYLSF AEMDEVSKKR IFSTILGTGA PNIAHFTDPL VEATIMVYST
ITSQLLPTPA KSHYTFNLRD LSKVFQGMLM ADPAKVEDKV QLLRLWYHEN CRVFRDRLVN
DEDRGWFDKL LESHMDEWEV GFEEVCPFQP ILYGDFMSPG SDVKSYELIT NERKVRVIEE
YMDDYNQINT AKLRLVLFMD AMSHVCRISR TLRQALGNAL LLGVGGSGRS SLTRLASHMA
EFECFQIELS KNYGMTEWRD DVKKVLLKAG LHNLPITFLF SDTQIKNESF LEDINNVLNS
GDIPNLYNMD EQDQIMNTMR PYIQEQGLQP TKANLMAAYT GRVRSSIHLV LCMSPIGEVF
RARLRQFPSL VNCCTIDWFN EWPAEALESV AIMFLSEIPE LDAGHRGCDK DTGPRYLAEL
ARHNYVTPKS YLELLNIFSI LVGQKKQELK TAKNRMKSGL DKVGPGASWA TVDTAIAEET
RNSVQAEEIK ANEKARKAQA IADDAQKDLD EALPALDAAL ASLRNLNKND VTEVRAMQRP
PPGVKLVIEA VCIMKGIKPK KVPGEKPGSK VDDYWEPGKG LLQDPGRFLE SLFKFDKDNI
GEAVIKAIQP YIDNEEFQPA AIAKVSKACT SICQWVRAMH KYHFVAKAVE PKRVSAGWPC
FLCLQQALRE AQDDLEVTQR ILEEAKQRLH EVEDGICEQR LGRADKLING LSDERVRWQE
TVESLEHMLD SIFGDVLVAA GFVAYLGPFT VRTQLVAHRV PHTAEPTLIG TLGNPVKIRS
WQIAGLPNDT LSVENGVINQ FSQRWTHFID PQGQANKWIK NMEKDNGLDV FKLSDRDFLR
SMENAIRFGK PCLLENVGEE LDPALEPVLL KQTYKQQGNT VLKLGDTVIP YHEDFKMYIT
TKLPNPHYTP EISTRLTLIN FTLSPSGLED QLLGQVVAEE RPDLEEAKNQ LIVSNAKMRQ
ELKDIEDQIL YRLSSSEGNP VDDMELIKVL EASKMKAAEI QAKVRIAEQT EKDIDLTRME
YVPVAVRTQI LFFCVSDLAN VDPMYQYSLE WFLNIFLSGI ANSERADNLK KRIANINHYL
TYNLYSNVCR SLFEKHKLMF AFLLCARIMM NQGKINQNEW RYLLSGGSVS VLSENPAPDW
LTDRAWRDIQ ALSNLPAFSS FTHDFVKHLP EFQAIFDSHE PHREPLPGIW DQYLDQFQKL
LVLRCLRGDK VTNAMQDFVA ANLEPRFIEP QATNLSLVFK DSNPTTPLIF VLSPGTDPAA
DLYKFAEEMK FSKKLSAISL GQGQGPRAEA MMRSSIERGK WVFFQNCHLA PSWMPVLERL
IEHINPDKVH RDFRLWLTSL PSNKFPVSIL QNGSKMTIEP PRGVKANLLK SYSSLSDEFL
NSCHKVMEFK CLLLSLCLFH GNALERRKFG PLGFNIPYEF TDGDLRICIS QLKMFLDEYD
HIPYKVLKYT AGEINYGGRV TDDWDRRCVM NILEDFYSPE VLFPEHSYSA SGVYHQIQPT
YDLNGYLSYV KSLPLNDMPE IFGLHDNANI TFAQNETYTL LGTIVQLQPK SSTAGGQSRE
EVCVEDVAQN ILIKVPDPVN LQWVMTKYPV LYEESMNTVL AQEVIRYNRL LQVITQSLRD
LLKALKGLVV MSSQLELMAA SLYNNSVPEL WKAKAYPSLK PLSSWVLDLL QRLDFLQTWI
SEGIPAVFWI SGFFFPQAFL TGTLQNYARK SVISIDTISF DFKVMRESVS ELKTRPKEGC
FIHGLFLEGA RWDPLAFQLA ESRPKELYTE MAVIWLLPTP NRKVQDQDFY LCPIYKTLTR
AGTLSTTGHS TNYVIAVEIP TDQPQRHWIK RGVALICALD Y
//
