GenomeNet

Database: UniProt
Entry: G3N309_BOVIN
LinkDB: G3N309_BOVIN
Original site: G3N309_BOVIN 
ID   G3N309_BOVIN            Unreviewed;      4667 AA.
AC   G3N309;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 2.
DT   24-JAN-2024, entry version 71.
DE   SubName: Full=Dynein axonemal heavy chain 8 {ECO:0000313|Ensembl:ENSBTAP00000056280.2};
GN   Name=DNAH8 {ECO:0000313|Ensembl:ENSBTAP00000056280.2,
GN   ECO:0000313|VGNC:VGNC:28127};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000056280.2, ECO:0000313|Proteomes:UP000009136};
RN   [1] {ECO:0000313|Ensembl:ENSBTAP00000056280.2, ECO:0000313|Proteomes:UP000009136}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000056280.2,
RC   ECO:0000313|Proteomes:UP000009136};
RA   Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA   Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA   Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT   "ARS-UCD1.2.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSBTAP00000056280.2}
RP   IDENTIFICATION.
RC   STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000056280.2};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC       {ECO:0000256|ARBA:ARBA00008887}.
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DR   Ensembl; ENSBTAT00000065917.2; ENSBTAP00000056280.2; ENSBTAG00000014063.6.
DR   VEuPathDB; HostDB:ENSBTAG00000014063; -.
DR   VGNC; VGNC:28127; DNAH8.
DR   GeneTree; ENSGT00940000158992; -.
DR   HOGENOM; CLU_000038_9_1_1; -.
DR   Proteomes; UP000009136; Chromosome 23.
DR   Bgee; ENSBTAG00000014063; Expressed in spermatid and 12 other cell types or tissues.
DR   ExpressionAtlas; G3N309; baseline.
DR   GO; GO:0005930; C:axoneme; IEA:UniProt.
DR   GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0031514; C:motile cilium; IEA:UniProt.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR   GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR   GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR   GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR   Gene3D; 1.10.287.2620; -; 1.
DR   Gene3D; 1.10.472.130; -; 1.
DR   Gene3D; 1.10.8.1220; -; 1.
DR   Gene3D; 1.10.8.710; -; 1.
DR   Gene3D; 1.20.1270.280; -; 1.
DR   Gene3D; 1.20.58.1120; -; 1.
DR   Gene3D; 1.20.920.20; -; 1.
DR   Gene3D; 1.20.920.30; -; 1.
DR   Gene3D; 3.10.490.20; -; 1.
DR   Gene3D; 6.10.140.1060; -; 1.
DR   Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR   Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR   Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR035699; AAA_6.
DR   InterPro; IPR035706; AAA_9.
DR   InterPro; IPR041658; AAA_lid_11.
DR   InterPro; IPR042219; AAA_lid_11_sf.
DR   InterPro; IPR026983; DHC_fam.
DR   InterPro; IPR041589; DNAH3_AAA_lid_1.
DR   InterPro; IPR042222; Dynein_2_N.
DR   InterPro; IPR043157; Dynein_AAA1S.
DR   InterPro; IPR041466; Dynein_AAA5_ext.
DR   InterPro; IPR041228; Dynein_C.
DR   InterPro; IPR043160; Dynein_C_barrel.
DR   InterPro; IPR024743; Dynein_HC_stalk.
DR   InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR   InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR   InterPro; IPR013602; Dynein_heavy_linker.
DR   InterPro; IPR013594; Dynein_heavy_tail.
DR   InterPro; IPR042228; Dynein_linker_3.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR46532:SF11; DYNEIN AXONEMAL HEAVY CHAIN 12; 1.
DR   PANTHER; PTHR46532; MALE FERTILITY FACTOR KL5; 1.
DR   Pfam; PF12774; AAA_6; 1.
DR   Pfam; PF12775; AAA_7; 1.
DR   Pfam; PF12780; AAA_8; 1.
DR   Pfam; PF12781; AAA_9; 1.
DR   Pfam; PF17857; AAA_lid_1; 1.
DR   Pfam; PF18198; AAA_lid_11; 1.
DR   Pfam; PF08385; DHC_N1; 1.
DR   Pfam; PF08393; DHC_N2; 1.
DR   Pfam; PF17852; Dynein_AAA_lid; 1.
DR   Pfam; PF18199; Dynein_C; 1.
DR   Pfam; PF03028; Dynein_heavy; 1.
DR   Pfam; PF12777; MT; 1.
DR   SMART; SM00382; AAA; 3.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Cilium {ECO:0000256|ARBA:ARBA00023069};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Dynein {ECO:0000256|ARBA:ARBA00023017};
KW   Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW   Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT   DOMAIN          2081..2225
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          2362..2515
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          2688..2836
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   REGION          1..83
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          3314..3380
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          3541..3575
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        42..56
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   4667 AA;  534166 MW;  0DD7FEC25D20A114 CRC64;
     MSAEEGDPPP PEEEAPPSSG ESAPPGSEEV ARPDPGDEAP PPAEEETPPP PSSEEAPTLP
     EEVSEGDTGS LSEKAPTSSL SDYLNLLPSD ERIVMPDDDE LEPGRVRPRP APRMVQSMLS
     DVLSQSSHRS SKYRRSMSGI PNLQETLKER QARYRDAREN RKMKIDPSYK YIFEILSEKL
     GLDMVTVEEL ILDCPSLEAF TLFFMKDGCK TLKFLYQEGD VPGLECGRTI AGATKGAKMM
     RLYVDNAAPE KLKGQCVFFV RCRNDIPINT KNIQEEVLFT VLDASEGLLV GIRNMLANIF
     LPAILATNSW GALNQSQQGE SEKQIFIETI NRYLSFLDGA RISIEGTVKL KKIDSVDFSK
     LHTFEDVTLA ASNSETVRQL EDVLMIWYKQ IEQVLIESEQ MRKEADDSGP LTELEHWKRM
     SAKFNYIIEQ IKGPSCKAVI NVLNVAHSKL LKNWRDLDAR ITDTANESKD NVRYLYTLEK
     VCQPLYNYDL VSMAHGIQNL INAIRMIHSV SRYYNTSERM TSLFIKVTNQ MVTACKAYIT
     DGGTNHVWDQ ETPVVLKKIQ DCIFLFKEYQ ASFHKTRKQI LESSGEKSFE VSEMYIFGKF
     EAFCKRLEKI TEMITVVQTY STLNNSTIEG IDILAIKFKN IYQGVKKKQY DILDPRRTEF
     DTDFLDFMTK INALEVQIQA FMNSSFGKIL SSQQALQLLQ RFQKLNIPCL QLEINHTIER
     ILQYYVAELE ATKKLYHSQK DDPPLARNMP PIAGKILWVR QLYRRISEPI NYFFKNSEIL
     SSAEGKAVIR QYNKISYVLV EFEVVYHTAW IREISQLQYA LQATLFVRHP ETGKLLVNFD
     PKILEVVRET KCMIKMKLDV PEQAKRLLKL ESKLKGDKLY LQGLLQHYDD LCQEVPPVFV
     NLMTPKMKKV EAVLRQGLTI LTWSSLTLES FFQEVDSVLG MFNQLLKKIN DLCEMHIDAV
     LKEIAKTLLI SLPETGATKV EDMLTLNETY TKEWAEVLNH KSKHVEEAVK ELISIFETIY
     EVKYSGKGAR HLPELRKHVV FGSEGEDVES ADYDANIVPE ADVKDDKEDE FKKECKEVYA
     FFSHQLLDSL QKATRLSLDT MKRRIFVASP YGRKRSEDVI SFLKSEVHLA IPNVMVPSLD
     DIQQAINRMI QLTLEVSRGV AHWGQQSRHI KRVISSTSRT TMDVAHSSPG KQLKKEERSF
     EEMIPARKLK NFYPGVAEHK DISKLVLLLS SSVNSLRKAV HEALQDFQKY KTLWTEDRDV
     KVKEFLANNP SLTEIRSEIL HYATFEQEID ELKPIIVVGA LELHTEPMKL ALSIEAKAWK
     MLLCRYLNEE YKKKMSDMIA FINEYLKKLS RPIRDLDDVR FAMEALSCIR DNEIQMDMTL
     GPIEEAYAIL NRFEVEVTKE ESEAVDTLRY SFNKLQSKAV SVQDELVQVQ PKFKSNLLES
     VEVFREDVMN FAEAYETEGP MVPNIPPQEA SNRLQIFQAN FDDLWRKFVT YSSGEQLFGL
     PVTDYEVLHK TRKELNLLQK LYGLYDTVMG NISGYYEILW GDVDIEKINA ELLEFQNRCR
     KLPKGLKDWQ AFLDLKKRID DFSESCPLLE MMTNKAMKQR HWDRISELTG TPFDVESDSF
     CLRNIMEAPL LKNKDDIEDI CISAIKEKDI EAKLTQVIEN WTNQNLSFAA FKGKGELLLK
     GTESGEIITL MEDSLMVLGS LLSNRYNAPF KKNIQNWVYK LSTSSDIIEE WLVVQNLWVY
     LEAVFVGGDI AKQLPQEAKR FQNIDKSWIK IMQRAHENPN VISCCVGDET MGQLLPHLHE
     QLEVCQKSLT GYLEKKRLLF PRFFFVSDPV LLEILGQASD SHTIQPHLPA VSDNINEVTF
     HAKDYDRIMA VISREGEKII LDSPVMAKGP VEIWLLDLLK MQMSSLHNII RSAFYQISDS
     GFQLLPFLNH FPAQVGLLGI QMLWTHDSEE ALNNAKDDRK IMQVTNQKFL DILNTLISQT
     THDLSKFDRV KFETLITIHV HQRDIFDDLV KMHIRSVTDF EWLKQSRFYF KEDLDQTVVS
     ITDVDFIYQN EFLGCTDRLV ITPLTDRCYI TLAQALGMNM GGAPAGPAGT GKTETTKDMG
     RCLGKYVVVF NCSDQMDFRG LGRIFKGLAQ SGSWGCFDEF NRIELPVLSV AAQQIYIVLT
     ARKERKKQFI FSDGDCVDLN PEFGIFLTMN PGYAGRQELP ENLKIQFRTV AMMVPDRQII
     MRVKLASCGF LENVILAQKF YVLYKLCEEQ LTKQVHYDFG LRNILSVLRT LGSQKRARPE
     DSELSTVMRG LRDMNLSKLI DEDEPLFLSL INDLFPGLQL DSNSYVELQA AVTNQVQLEG
     LINHPPWNLK LVQLYETSLV RHGLMTLGPS GSGKTMVITI LMKALTECGR PHREMRMNPK
     AITAPQMFGR LDTATNDWTD GIFSTLWRKT LKAKKGENIF LVLDGPVDAI WIENLNSVLD
     DNKTLTLANG DRIPMAPSCK LLFEVHNIEN ASPATVSRMG MVYISSSALS WRPILQAWLK
     KRTTQENNVF LTLYDKIFED AYTFMKLNLN PKMQLLECNY IVQSLNLLEG LIPSKEEGGI
     SCVEHLHKLF VFALMWSLGA LLELESRDKL EAFMRSHESK LDLPEIPKGL TQTMYEFYVT
     DYGDWEHWNK KLQPYYYPTD SVPEYSSILV PNVDNVRTNF LIDTIAKQHK AVLLTGEQGT
     AKTVMIKAYL KKYDPEVQLS KSLNFSSATE PMMFQRTIES YVDKRMGSTY GPPGGRKMTV
     FIDDINMPVI NEWGDQITNE IVRQMMEMEG MYSLDKPGDF TTIVDVQLIA AMIHPGGGRN
     DIPQRLKRQF TVFNCTLPSN ASIDKIFGVI GCGYFDACRR FKPEICEMIL NLVSASRMLW
     QWTKVKMLPT PSKFHYIFNL RDLSRIWQGM LTIKADECAS VHVLLSLFKH ECNRVIADRF
     ITPDDEQWFN TQLVRSVEEN VSPDVGSYIL PEPYFVDFLR EMPEPTGDEP EDTAFEVPKV
     YELVPSFEFL SEKLQFYQRQ FNEIIRGTSL DLVFFKDAMT HLIKISRIIR TSCGNALLVG
     VGGSGKQSLS RLASFIAGYQ IFQITLTRSY NVSNLTDDLK GLYKVAGADG KGITFIFTDN
     EIKDEAFLEY LNNLLSSGEI SNLFARDEMD EITQGLISVM KRELPRHPPT FDNLYEYFIS
     RSRKNLHVVL CFSPVGEKFR ARSLKFPGLI SGCTMDWFSR WPREALVAVA SYFVSGYSIV
     CSSDTKRQVV ETMGLFHDMV SESCESYFQR YRRRAHVTPK SYLSFINGYK NIYTEKVKYI
     NEQAERMNIG LDKLMEASES VAKLSQDLAV KEKELAVASV KADEVLAEVT VSAQASAKVK
     NEVQEVKDKA QKIVDEIDSE KVIAETKLEA ARPALEEAEA ALNTIKPNDI ATVRKLAKPP
     HLIMRIMDCV LLLFQKKIDP VTMDPEKPCC KPSWGESLKL MSATGFLWSL QQFPKDTINE
     ETVELLQPYF NMDDYTFESA KKVCGNVAGL LSWTLAMATF YGVNREVLPL KANLAKQEGR
     LAVANAELGK AQALLDEKQA ELDKVQAKFD AAMNEKMIFR NYLLKEQWEI ELKARKIPFT
     ENLNLISMLV DPPTIGEWGL QGLPGDDLSI QNGIIVTKAT RYPLLIDPQT QGKTWIKSKE
     KENDLQVTSL NHKYFRTHLE DSLSLGRPLL IEDIREELDP ALDNVLEKNF IKSGTTFKVK
     VGDKECDVMD TFKLYITTKL PNPAFTPEIN AKTSVIDFTV TMKGLENQLL RRVILTEKQE
     LESERVKLLE DVTFNKRKMK ELEDNLLYKL SATKGSLVDD ESLIGVLRTT KLTAAEVSEK
     LHVAAETEVK INTAQEEFRP AATRGSILYF LITEMSMVNI MYQTSLAQFL KLFDQSMARS
     EKSPLPQKRI TNIIEYLTYE VFTYSVRGLY ENHKFLFVLL MTLKIDLQRG TVKHREFQAL
     IKGGAALDLK ACPPKPFRWI LDMTWLNLVE LSKLPQFAEI MNQISRNEKG WKSWFDKDAP
     EEEIIPDGYN DSLDTCRKLL LIRSWCPDRT VFQARKYIAD SLEEKYTEPV ILNLEKTWEE
     SDTRTPLICF LSMGSDPTIQ IDALAKKLKL ECRTISMGQG QEVHARKLIQ MSMQQGGWVL
     LQNCHLGLEF MEELLETLTI TETIDDTFRV WITTEPHIRF PITLLQTSLK FTNEPPQGVR
     AGLKRTFAGI NQDLLDISNL PMWKPMLYTV AFLHSTVQER RKFGPLGWNI PYEFNSADFS
     ASVQFIQNHL DECDIKKGVS WNTVRYMIGE VQYGGRVTDD FDKRLLNCFA RVWFSEKMFE
     PSFCFYTGYK IPVCKTLDQY FEYIQSLPSL DNPEVFGLHP NADITYQSNT ASAVLETITN
     IQPKESGGGV GETREAIVYR LSEDMLSKLP PDYVPHEVKA RLIKMGHLNS MNIFLRQEID
     RMQKVISILR SSLNDLKLAI EGTIIMSENL RDALDNMYDA RIPQIWKRVS WDSSTLGFWF
     TELLERNAQF STWIFEGRPN VFWMTGFFNP QGFLTAMRQE VTRAHKGWAL DSVTIHNEVL
     RQTKEEVTSP PAEGVYIYGL YMDGAAWDRR NGKLTESTPK VLFTQLPVLH IFAINSTAPK
     DPKLYVCPIY KKPRRTDLTF ITVVYLRTVL SPDHWILRGV ALLCDIK
//
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