ID G3N309_BOVIN Unreviewed; 4667 AA.
AC G3N309;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 24-JAN-2024, entry version 71.
DE SubName: Full=Dynein axonemal heavy chain 8 {ECO:0000313|Ensembl:ENSBTAP00000056280.2};
GN Name=DNAH8 {ECO:0000313|Ensembl:ENSBTAP00000056280.2,
GN ECO:0000313|VGNC:VGNC:28127};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|Ensembl:ENSBTAP00000056280.2, ECO:0000313|Proteomes:UP000009136};
RN [1] {ECO:0000313|Ensembl:ENSBTAP00000056280.2, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000056280.2,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000056280.2}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000056280.2};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR Ensembl; ENSBTAT00000065917.2; ENSBTAP00000056280.2; ENSBTAG00000014063.6.
DR VEuPathDB; HostDB:ENSBTAG00000014063; -.
DR VGNC; VGNC:28127; DNAH8.
DR GeneTree; ENSGT00940000158992; -.
DR HOGENOM; CLU_000038_9_1_1; -.
DR Proteomes; UP000009136; Chromosome 23.
DR Bgee; ENSBTAG00000014063; Expressed in spermatid and 12 other cell types or tissues.
DR ExpressionAtlas; G3N309; baseline.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46532:SF11; DYNEIN AXONEMAL HEAVY CHAIN 12; 1.
DR PANTHER; PTHR46532; MALE FERTILITY FACTOR KL5; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136}.
FT DOMAIN 2081..2225
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2362..2515
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2688..2836
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 1..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3314..3380
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3541..3575
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 42..56
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4667 AA; 534166 MW; 0DD7FEC25D20A114 CRC64;
MSAEEGDPPP PEEEAPPSSG ESAPPGSEEV ARPDPGDEAP PPAEEETPPP PSSEEAPTLP
EEVSEGDTGS LSEKAPTSSL SDYLNLLPSD ERIVMPDDDE LEPGRVRPRP APRMVQSMLS
DVLSQSSHRS SKYRRSMSGI PNLQETLKER QARYRDAREN RKMKIDPSYK YIFEILSEKL
GLDMVTVEEL ILDCPSLEAF TLFFMKDGCK TLKFLYQEGD VPGLECGRTI AGATKGAKMM
RLYVDNAAPE KLKGQCVFFV RCRNDIPINT KNIQEEVLFT VLDASEGLLV GIRNMLANIF
LPAILATNSW GALNQSQQGE SEKQIFIETI NRYLSFLDGA RISIEGTVKL KKIDSVDFSK
LHTFEDVTLA ASNSETVRQL EDVLMIWYKQ IEQVLIESEQ MRKEADDSGP LTELEHWKRM
SAKFNYIIEQ IKGPSCKAVI NVLNVAHSKL LKNWRDLDAR ITDTANESKD NVRYLYTLEK
VCQPLYNYDL VSMAHGIQNL INAIRMIHSV SRYYNTSERM TSLFIKVTNQ MVTACKAYIT
DGGTNHVWDQ ETPVVLKKIQ DCIFLFKEYQ ASFHKTRKQI LESSGEKSFE VSEMYIFGKF
EAFCKRLEKI TEMITVVQTY STLNNSTIEG IDILAIKFKN IYQGVKKKQY DILDPRRTEF
DTDFLDFMTK INALEVQIQA FMNSSFGKIL SSQQALQLLQ RFQKLNIPCL QLEINHTIER
ILQYYVAELE ATKKLYHSQK DDPPLARNMP PIAGKILWVR QLYRRISEPI NYFFKNSEIL
SSAEGKAVIR QYNKISYVLV EFEVVYHTAW IREISQLQYA LQATLFVRHP ETGKLLVNFD
PKILEVVRET KCMIKMKLDV PEQAKRLLKL ESKLKGDKLY LQGLLQHYDD LCQEVPPVFV
NLMTPKMKKV EAVLRQGLTI LTWSSLTLES FFQEVDSVLG MFNQLLKKIN DLCEMHIDAV
LKEIAKTLLI SLPETGATKV EDMLTLNETY TKEWAEVLNH KSKHVEEAVK ELISIFETIY
EVKYSGKGAR HLPELRKHVV FGSEGEDVES ADYDANIVPE ADVKDDKEDE FKKECKEVYA
FFSHQLLDSL QKATRLSLDT MKRRIFVASP YGRKRSEDVI SFLKSEVHLA IPNVMVPSLD
DIQQAINRMI QLTLEVSRGV AHWGQQSRHI KRVISSTSRT TMDVAHSSPG KQLKKEERSF
EEMIPARKLK NFYPGVAEHK DISKLVLLLS SSVNSLRKAV HEALQDFQKY KTLWTEDRDV
KVKEFLANNP SLTEIRSEIL HYATFEQEID ELKPIIVVGA LELHTEPMKL ALSIEAKAWK
MLLCRYLNEE YKKKMSDMIA FINEYLKKLS RPIRDLDDVR FAMEALSCIR DNEIQMDMTL
GPIEEAYAIL NRFEVEVTKE ESEAVDTLRY SFNKLQSKAV SVQDELVQVQ PKFKSNLLES
VEVFREDVMN FAEAYETEGP MVPNIPPQEA SNRLQIFQAN FDDLWRKFVT YSSGEQLFGL
PVTDYEVLHK TRKELNLLQK LYGLYDTVMG NISGYYEILW GDVDIEKINA ELLEFQNRCR
KLPKGLKDWQ AFLDLKKRID DFSESCPLLE MMTNKAMKQR HWDRISELTG TPFDVESDSF
CLRNIMEAPL LKNKDDIEDI CISAIKEKDI EAKLTQVIEN WTNQNLSFAA FKGKGELLLK
GTESGEIITL MEDSLMVLGS LLSNRYNAPF KKNIQNWVYK LSTSSDIIEE WLVVQNLWVY
LEAVFVGGDI AKQLPQEAKR FQNIDKSWIK IMQRAHENPN VISCCVGDET MGQLLPHLHE
QLEVCQKSLT GYLEKKRLLF PRFFFVSDPV LLEILGQASD SHTIQPHLPA VSDNINEVTF
HAKDYDRIMA VISREGEKII LDSPVMAKGP VEIWLLDLLK MQMSSLHNII RSAFYQISDS
GFQLLPFLNH FPAQVGLLGI QMLWTHDSEE ALNNAKDDRK IMQVTNQKFL DILNTLISQT
THDLSKFDRV KFETLITIHV HQRDIFDDLV KMHIRSVTDF EWLKQSRFYF KEDLDQTVVS
ITDVDFIYQN EFLGCTDRLV ITPLTDRCYI TLAQALGMNM GGAPAGPAGT GKTETTKDMG
RCLGKYVVVF NCSDQMDFRG LGRIFKGLAQ SGSWGCFDEF NRIELPVLSV AAQQIYIVLT
ARKERKKQFI FSDGDCVDLN PEFGIFLTMN PGYAGRQELP ENLKIQFRTV AMMVPDRQII
MRVKLASCGF LENVILAQKF YVLYKLCEEQ LTKQVHYDFG LRNILSVLRT LGSQKRARPE
DSELSTVMRG LRDMNLSKLI DEDEPLFLSL INDLFPGLQL DSNSYVELQA AVTNQVQLEG
LINHPPWNLK LVQLYETSLV RHGLMTLGPS GSGKTMVITI LMKALTECGR PHREMRMNPK
AITAPQMFGR LDTATNDWTD GIFSTLWRKT LKAKKGENIF LVLDGPVDAI WIENLNSVLD
DNKTLTLANG DRIPMAPSCK LLFEVHNIEN ASPATVSRMG MVYISSSALS WRPILQAWLK
KRTTQENNVF LTLYDKIFED AYTFMKLNLN PKMQLLECNY IVQSLNLLEG LIPSKEEGGI
SCVEHLHKLF VFALMWSLGA LLELESRDKL EAFMRSHESK LDLPEIPKGL TQTMYEFYVT
DYGDWEHWNK KLQPYYYPTD SVPEYSSILV PNVDNVRTNF LIDTIAKQHK AVLLTGEQGT
AKTVMIKAYL KKYDPEVQLS KSLNFSSATE PMMFQRTIES YVDKRMGSTY GPPGGRKMTV
FIDDINMPVI NEWGDQITNE IVRQMMEMEG MYSLDKPGDF TTIVDVQLIA AMIHPGGGRN
DIPQRLKRQF TVFNCTLPSN ASIDKIFGVI GCGYFDACRR FKPEICEMIL NLVSASRMLW
QWTKVKMLPT PSKFHYIFNL RDLSRIWQGM LTIKADECAS VHVLLSLFKH ECNRVIADRF
ITPDDEQWFN TQLVRSVEEN VSPDVGSYIL PEPYFVDFLR EMPEPTGDEP EDTAFEVPKV
YELVPSFEFL SEKLQFYQRQ FNEIIRGTSL DLVFFKDAMT HLIKISRIIR TSCGNALLVG
VGGSGKQSLS RLASFIAGYQ IFQITLTRSY NVSNLTDDLK GLYKVAGADG KGITFIFTDN
EIKDEAFLEY LNNLLSSGEI SNLFARDEMD EITQGLISVM KRELPRHPPT FDNLYEYFIS
RSRKNLHVVL CFSPVGEKFR ARSLKFPGLI SGCTMDWFSR WPREALVAVA SYFVSGYSIV
CSSDTKRQVV ETMGLFHDMV SESCESYFQR YRRRAHVTPK SYLSFINGYK NIYTEKVKYI
NEQAERMNIG LDKLMEASES VAKLSQDLAV KEKELAVASV KADEVLAEVT VSAQASAKVK
NEVQEVKDKA QKIVDEIDSE KVIAETKLEA ARPALEEAEA ALNTIKPNDI ATVRKLAKPP
HLIMRIMDCV LLLFQKKIDP VTMDPEKPCC KPSWGESLKL MSATGFLWSL QQFPKDTINE
ETVELLQPYF NMDDYTFESA KKVCGNVAGL LSWTLAMATF YGVNREVLPL KANLAKQEGR
LAVANAELGK AQALLDEKQA ELDKVQAKFD AAMNEKMIFR NYLLKEQWEI ELKARKIPFT
ENLNLISMLV DPPTIGEWGL QGLPGDDLSI QNGIIVTKAT RYPLLIDPQT QGKTWIKSKE
KENDLQVTSL NHKYFRTHLE DSLSLGRPLL IEDIREELDP ALDNVLEKNF IKSGTTFKVK
VGDKECDVMD TFKLYITTKL PNPAFTPEIN AKTSVIDFTV TMKGLENQLL RRVILTEKQE
LESERVKLLE DVTFNKRKMK ELEDNLLYKL SATKGSLVDD ESLIGVLRTT KLTAAEVSEK
LHVAAETEVK INTAQEEFRP AATRGSILYF LITEMSMVNI MYQTSLAQFL KLFDQSMARS
EKSPLPQKRI TNIIEYLTYE VFTYSVRGLY ENHKFLFVLL MTLKIDLQRG TVKHREFQAL
IKGGAALDLK ACPPKPFRWI LDMTWLNLVE LSKLPQFAEI MNQISRNEKG WKSWFDKDAP
EEEIIPDGYN DSLDTCRKLL LIRSWCPDRT VFQARKYIAD SLEEKYTEPV ILNLEKTWEE
SDTRTPLICF LSMGSDPTIQ IDALAKKLKL ECRTISMGQG QEVHARKLIQ MSMQQGGWVL
LQNCHLGLEF MEELLETLTI TETIDDTFRV WITTEPHIRF PITLLQTSLK FTNEPPQGVR
AGLKRTFAGI NQDLLDISNL PMWKPMLYTV AFLHSTVQER RKFGPLGWNI PYEFNSADFS
ASVQFIQNHL DECDIKKGVS WNTVRYMIGE VQYGGRVTDD FDKRLLNCFA RVWFSEKMFE
PSFCFYTGYK IPVCKTLDQY FEYIQSLPSL DNPEVFGLHP NADITYQSNT ASAVLETITN
IQPKESGGGV GETREAIVYR LSEDMLSKLP PDYVPHEVKA RLIKMGHLNS MNIFLRQEID
RMQKVISILR SSLNDLKLAI EGTIIMSENL RDALDNMYDA RIPQIWKRVS WDSSTLGFWF
TELLERNAQF STWIFEGRPN VFWMTGFFNP QGFLTAMRQE VTRAHKGWAL DSVTIHNEVL
RQTKEEVTSP PAEGVYIYGL YMDGAAWDRR NGKLTESTPK VLFTQLPVLH IFAINSTAPK
DPKLYVCPIY KKPRRTDLTF ITVVYLRTVL SPDHWILRGV ALLCDIK
//