ID G3N6J3_GASAC Unreviewed; 2047 AA.
AC G3N6J3;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Zonadhesin, like {ECO:0000313|Ensembl:ENSGACP00000000918.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000000918.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000000918.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000000918.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR Ensembl; ENSGACT00000000918.1; ENSGACP00000000918.1; ENSGACG00000000704.1.
DR GeneTree; ENSGT00940000156850; -.
DR OMA; NHTRGCF; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000000704; Expressed in intestinal epithelial cell and 1 other cell type or tissue.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd19941; TIL; 5.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 6.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000998; MAM_dom.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR002919; TIL_dom.
DR InterPro; IPR025615; TILa_dom.
DR InterPro; IPR014853; VWF/SSPO/ZAN-like_Cys-rich_dom.
DR InterPro; IPR001007; VWF_dom.
DR InterPro; IPR001846; VWF_type-D.
DR PANTHER; PTHR46160; ALPHA-TECTORIN-RELATED; 1.
DR PANTHER; PTHR46160:SF4; VWFD DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF08742; C8; 4.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF00629; MAM; 1.
DR Pfam; PF01826; TIL; 5.
DR Pfam; PF12714; TILa; 4.
DR Pfam; PF00094; VWD; 4.
DR PRINTS; PR01217; PRICHEXTENSN.
DR SMART; SM00832; C8; 4.
DR SMART; SM00181; EGF; 5.
DR SMART; SM00179; EGF_CA; 1.
DR SMART; SM00215; VWC_out; 4.
DR SMART; SM00216; VWD; 4.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57567; Serine protease inhibitors; 5.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS50060; MAM_2; 1.
DR PROSITE; PS51233; VWFD; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1987..2010
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..79
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 387..564
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 773..951
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 1161..1340
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 1549..1725
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 1937..1974
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 97..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 555..575
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 922..945
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 106..122
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..274
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 922..940
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1964..1973
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2047 AA; 220396 MW; 289AAC9EEE15C746 CRC64;
MYGSDNQNVL RVLAKRPGSD DEVWKKIGIQ SPSWLKGSIT VSKQSAQDIA IVFEAQRGFS
SSCDTALDNI VISEGACPVP LEKLLKLILL LMPSTPGPTT PKPPNSEIPL GTVSLNCAKP
STPGPTTPKP STPGPTTPKP TTPRPTTPGP TTPKPPIFFP PKPSTPGPTT PKPSTPGPTT
PKPTTPRPTT PGPTTPKPPT KPSTPGPTTP KPSTPGPTTP KPTTPRPTTP GPTTPKPPSP
TTPKPSTPGP TTPKPTTPRP TTPGPTTPKP PTPKCPPNSH YEACADPCQE TCSGKPPSCG
GPCSESCVCD PGYVLSAGKC VKKTSCGCTH VNGQYYEPGE IIFGDGCSKL CRCAGNYTLE
CVDNSCDPTE ECRDVNGVAG CYPKGSQDCV VSGDPHYNTF DKKFFTFMGT CTYTLARTCK
NTTGPWFSVE GKNEERGVPG MSYLRKLYVT VDGITVTLMK AKRTLVNGRR VAFPNSPSPL
ISLSLAGQYV TLQTSFGLRV RWDGSHYAQI SVPSSYYDQM CGLCGDYDGN PGNDFTKPDG
TLVGNVNDFG NSWQTKEDED DSCSPGTKPD PDCDPKLEAE VVKPDKCGKI TDPAGPFREC
ISVVDPTPFF QSCVYDMCQF GGQQRVLCDQ LQAYTDACQS AGAKVHQWRT PGFCSLECPP
NSSYTLCASS CPETCLGVVA SPSCQDVCVE GCECNPGFIL SNDKCVSLKD CGCVDTSGTY
HPVGDNWYLE GCEHKCDCHS GGLIQCHNSS CKPTTESCQL KDGEYECLPL GNGICSVSGD
PHYTTFDKHT HHYMGACSYT LSKPCNVSSG SPYFSVDTQN EHRGSSKKVS YVRAVVVNVN
GVTVVLGKGR TVQVNGTVVV PPVTSIGGVK IYLSGKFVVL ETSFGLRVRF DGNHHADVTL
PISYNGLLCG MCGNFNGNSK DDNLKPDNTP AANTNELGDS WQVPDPRPDC TNGGGQEDCD
EVVEEEAKKP TSCGMITDPN GSLFKPCHVV VPPEPYFGNC VYDMCATGGQ TVALCQAIES
YADLCAAAGV PIPWRNYTFC PLKCPAGSHY DSCSPACAQP SCQQPATPGG SCDLPCVEGC
VCSPGLILSG DKCVPLSECG CTDTDGLYRP VGDSWFTETD CSERCKCNGN NNITCEPWQC
SPAQECKVVE GVLDCHSTGK GVCHVAGDPH YYTFDGVMHT FMGTCTYTLV EVCNTTKVTP
FKIVAKNEER GQPEASYVRS VKVYLPHDTV VELQKSRRVS LNGRRVKTPL SIDLAGAKVI
TSGSYSLLDT NFGLQVKFDG VHHLEITVPG EYFNKLCGMC GNYNHNSSDE YLMPNKKPAK
DVIELGNSWK SDGDSDPGCQ PDTRPNIHPN CTAEEEKLYE AQCAGVILSD RFKPCHSLVP
PEAFLGNCIY DLCEYDGMQA TLCDNVDAYA QACQSSGVTI SWRNSTFCPV PCPANSHYSD
CTPPCPPTCS DLFPIFCHLP STTCVEGCQC DGGYVLSDSK CVPLDKCGCL GSDGEYHETR
SLIIETIITR TCSCNLGGQI TCKDHTCSSN SVCSLDKYGD VYCKPTNFDK CSISGDPHHR
TFDGFTHHFQ GPYTYVLTQS HNLQNSLTPF VVRGKNMRRG GNRRVSFLDQ MYIDVYGVNV
RFLQKKSVLL NGERVAPPLR PVDGLTITMN SKQVQLTTDF GLTVRFDGNI RGEIILPSTY
KNAVRGLCGN YDGITRNEYM KPDGTVVRDL NNFGESWRVT FWHSVSRREV EADPDSGFET
SDCSQSELNG YNSVAQCGAL SDSKGPFAAC HATLPPKTYQ DDCVFDLCAE SGNAALRCAS
YEAYAAACQE AGVKLEPWRQ QLDCVLSCDA NSTYSPCMSP CPPSCADLAA PSECEATSCM
EGCQCAAGFV MSEGVCVPYT QCGCSVLNRY YTLKEEFVTE DCSQACECTS TGAVCRPKTC
QSGFVCTVYD FKRECYRASP CLSYPCLNGG QCADASNNTY TCQCAEGFEG DNCEVEITPS
GGLETKWIIL IAVMVAVVVI IIVTAVACAC RQKAKNRKGN MERLSLKSTT VLYTDMDKER
KDKMTTM
//
