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Database: UniProt
Entry: G3N6V5_GASAC
LinkDB: G3N6V5_GASAC
Original site: G3N6V5_GASAC 
ID   G3N6V5_GASAC            Unreviewed;      1770 AA.
AC   G3N6V5;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   25-OCT-2017, entry version 42.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000001030, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000001030}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000001030}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSGACP00000001030}.
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DR   STRING; 69293.ENSGACP00000001030; -.
DR   Ensembl; ENSGACT00000001030; ENSGACP00000001030; ENSGACG00000000800.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   InParanoid; G3N6V5; -.
DR   OMA; LNQTECR; -.
DR   TreeFam; TF312805; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0008331; F:high voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0050856; P:regulation of T cell receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0043029; P:T cell homeostasis; IEA:InterPro.
DR   GO; GO:0007601; P:visual perception; IEA:InterPro.
DR   InterPro; IPR031688; CAC1F_C.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR030157; VDCC_L_a1F.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF184; PTHR10037:SF184; 3.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16885; CAC1F_C; 2.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007635};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21   1770       Voltage-dependent L-type calcium channel
FT                                subunit alpha. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003448052.
FT   TRANSMEM     40     59       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     71     88       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    148    171       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    227    248       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    260    282       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    418    436       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    456    480       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    487    510       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    545    567       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    621    645       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    724    743       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    755    777       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    797    820       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    841    874       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1015   1036       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1048   1068       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1143   1161       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1235   1258       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1392   1426       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
SQ   SEQUENCE   1770 AA;  198979 MW;  B35321A59F8788B3 CRC64;
     PFDIFILLAI FANCVALGVS KPFPEDDSNS TNHDLEQVEY VFLIIFTIET FLKILAYGLV
     MHPSSYIRNG WNLLDFVIVI VGLFSVVLET MTHKSGEVAT THHVPGKPGG LDVKALRAFR
     VLRPLRLVSG VPSLQIVLNS IMKAMVPLLH IALLVLFVII IYAIIGLELF IGRMHRTCYY
     KESDNYVEDD PVPCAFLGHG RQCSINGTEC RGRWDGPNGG ITNFDNFFFA MLTVFQCITM
     EGWTDVLYWM NDAIGFELPW VYFVSLVIFG SFFVLNLVLG VLSGEFSKER EKAKARGDFQ
     KLREKQQMEE DLCGYMDWIT QAEDMDELDE EGNPRPSLGD LSDKKRGKFG WFSHSTETHA
     ASLPASETAS ENTENIDEEH TNCCQNCCSR IMKISCCRTL RRWNRVCRRN CRTAVKSVTF
     YWLVLLLVFL NTSLSASEHY NQPDWLTEVQ DIANKVLLSL FTVEMLLKMY SLGLAHYFVA
     FFNRFDCFVV CGGIVETILV ELGIMPPLGI SVLRCVRLLR IFKVTRHWTA LSNLVASLLN
     SMKSIASLLL LLFLFLIIFA LLGMQLFGGK FNFDETQTKR STFDAFPQAL LTCFQILTGE
     DWNMVMYDGI MAYGGPVFPG MIVCVYFVIL FICDILLNVF LAIAVDNLAG GDGDKEKNKK
     TEGAKEAEGK VDIDEDTEYE EEEEPPEGAD EEKVLPIPEG SAFFCLSKTN PIRVFCHTLI
     HHHIFTNLIL VFIILSSCSL AAEDPIRAHS FRNNILGYAD YAFTSIFTVE ILLKMAVHGA
     FLHQGSFCRN WFNLLDLLVV SVSLVSFFLH SSAISVVKIL RVLRVLRPLR AINRAKGLKH
     VVQCVFVAIK TIGNIMIVTT LLQFMFACIG VQLFKGKFYR CTDEAKHTPD QCKGTFVVYK
     DGDVNHPMVR ERIWLNSDFN FDNVLMGMMA LFTVSTFEGW PALLYKAIDA NGENSGPIYN
     YRVGEQGEQE YKNCELDKNQ RQCVEFALKA QPLKLYIPKN PVQFKFWSII NSTGFEYVMF
     VLILLNTVTL AVQQHYEQSK KFSHIMDILN MVFTGLFTAE MLLKLLALRL RHYFVDAWNS
     FDALIVVGSV VDIVVTEFSS GEDSSRVSIT FFRLFRVMRL VKLLSKGEGI RTLLWTFIKS
     LQALPYVALL IAMIFFIYAV IGMQTFGKVA MQDLTQINRN NNFQTFPQAF GHVCRCATGE
     AWQEIMLASL PGKRCDPESD YEPGEEFSCG SNFAIVYFIS FFMLCAFLII NLFVAVIMDN
     FDYLTRDWSI LGPHHLDEFK RIWSEYDPEA KGRIKHLDVV ALLRRIQPPL GFGKLCPHRV
     ACKRLVAMNM PLNADGMVTF NATLFALVRT ALKIKTEGNP DQENEELRGI IKKIWKRMKP
     KLLDEVIPPH EEEEVTVGKF YATFLIQDYF RKFRKRKEKG DLPGESDTTN PSAVQQLCKA
     GLKTLQDLGP EMRLALNEDG DSVGLERERR GSALATPTGS HLAVEGGVSN GGLIHRVGSV
     IKTPNCGEHD QRRRRGDADR CFVNLHHQRR RNGRKPSFNI QCLRRQGSSD DLPIPGTYHP
     TSPPRRTRTQ QTFSSYESRH SSGRSSAASS ASWANPCPRR GRLLYAPLIL VEEEGSPPWG
     GGGRGGQEGK TGGAERGVNV TGAAPAWYGG PAGTSAPPPY KAYTTLRVPS QLGAQLTEKR
     GSADSLVEAV LISEGLGLYA RDPKFVAFAK REIADACHMT VDEMESAASD LLGSPALLAD
     PAALYSDEEP IRTGHDEDEL ADEMTCVTSF
//
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