ID G3NGA8_GASAC Unreviewed; 2094 AA.
AC G3NGA8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Ash1 (absent, small, or homeotic)-like (Drosophila) {ECO:0000313|Ensembl:ENSGACP00000004363.3};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000004363.3, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000004363.3, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000004363.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR STRING; 69293.ENSGACP00000004363; -.
DR Ensembl; ENSGACT00000004377.3; ENSGACP00000004363.3; ENSGACG00000003327.3.
DR eggNOG; KOG1083; Eukaryota.
DR GeneTree; ENSGT00940000156698; -.
DR InParanoid; G3NGA8; -.
DR OMA; DKDNGHE; -.
DR TreeFam; TF106416; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000003327; Expressed in telencephalon and 13 other cell types or tissues.
DR GO; GO:0005694; C:chromosome; IEA:UniProt.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0140938; F:histone H3 methyltransferase activity; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:UniProt.
DR CDD; cd04717; BAH_polybromo; 1.
DR CDD; cd05525; Bromo_ASH1; 1.
DR CDD; cd15548; PHD_ASH1L; 1.
DR CDD; cd19174; SET_ASH1L; 1.
DR Gene3D; 2.30.30.490; -; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR017956; AT_hook_DNA-bd_motif.
DR InterPro; IPR006560; AWS_dom.
DR InterPro; IPR001025; BAH_dom.
DR InterPro; IPR043151; BAH_sf.
DR InterPro; IPR043320; Bromo_ASH1L.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR043319; PHD_ASH1L.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46147; HISTONE-LYSINE N-METHYLTRANSFERASE ASH1; 1.
DR PANTHER; PTHR46147:SF2; SET-BINDING PROTEIN; 1.
DR Pfam; PF17907; AWS; 1.
DR Pfam; PF01426; BAH; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF20826; PHD_5; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00384; AT_hook; 5.
DR SMART; SM00570; AWS; 1.
DR SMART; SM00439; BAH; 1.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00249; PHD; 1.
DR SMART; SM00508; PostSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF47370; Bromodomain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51215; AWS; 1.
DR PROSITE; PS51038; BAH; 1.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 1211..1262
FT /note="AWS"
FT /evidence="ECO:0000259|PROSITE:PS51215"
FT DOMAIN 1265..1381
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 1389..1405
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT DOMAIN 1574..1644
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 1780..1917
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT REGION 1..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 171..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 281..380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 529..570
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 616..644
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 702..741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 801..859
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 950..1111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1428..1456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1673..1698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1954..2046
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..240
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 302..332
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 619..634
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 821..843
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 844..859
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 990..1004
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1078..1094
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1677..1698
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1968..2020
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2021..2040
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2094 AA; 237317 MW; CBCB01CC563EEA13 CRC64;
KRGRPKSIMP RLDGPARGCL PNKLVPSKVF SSLLKSKEEQ DPPVLHPEVD LNPPKPMPRK
RGRPKRLPPT LPQEGQPPTL APEAGDMGDK RFRTKGNGQL IMKTIIGKIN KMKSMRRKRI
LSQILLGPRP EDTPKCTTSG VVGSVEAATQ SLSSLAASFG GKLGPQINVS KKGTIYMGKR
RGRKPKSASN STTPPPEPFL SPNTTSPLHH HQSHQHHQLS SSEVFPSPSL SQSSGGHSPI
SDASFVEPGS VHFAAASQKK SSYRGYQHDH HYRQHYHYHR LSPSRPLHPT SPAPLSELKE
ATPSPVSESH SEETVPSDSG IGTDNNSTSD RGEKAGGLGG ARSSPDPRRP HPAAPASSLI
GHKDKHKHKC KRRTHGCPGY DKLKRQKRKR KKKFLQLRSR RHDPDFLAEL EEIVVRLSEI
RITHRGPPPH HYVHRDLLPT IFRVNFGSFY SHPAYSCDPL HYVRKPDMKK KRGRPPKLRE
SMSEVPFVPG LGFPLSSGGF YHPSYAVPYS SGPLGLGYYR GYPPASALYP HPHHQSPHTA
PSHHSHHSPS FPPPPPTSYM HHHHPSHLLL NPSKFHKKKH KLLRQDYLGG GRSPVLYPPM
SSELSFNWHH KHKHRHKHRE RCSEDDREEA ARAGSASRAR MAESLQRCRF GRDAASTKRY
KRKESSMSCL GPSRLALGNG SKGHQPVESW FRMGSSKASY SKLSRSHVAP GQAGCSDSED
EEPLSPTEDV EPGAHDSPNR TNLFASALTR TTLKGGKNRK TEAVTESSAF SRIDRPIRKD
LGGKTLKEGD IACQTFSGIR MQDPAPQQWP SEGLTECPLT KTDLSGGSLR SSLQNGTTKG
GHSSSESDES ETKLKKRNVE NEDEAIVLSY CSSIQGVALS PPEGPDVPMH HRQQHHHLQP
SMFHSHGSAS SSCLSPSQDC CLDASPPHHS HRAQPSKHSL HHVNKILRAK KLQRQARTGN
NVVKKRGPGR PRKHPLPSPL PSPPPAVELN QVRHRDRVTE RPVGGRGWEG DTVTDAIEAV
VQGQRRKSQK RKQWAGDEEE EEEEDEDEED GEKPSHGSLS SAMESKPDGQ CSPDRPTTAP
PEQAPPMPVI PQREKRPARP PKKKFQKAGL YSNVYKTEDP RSQLLQLKKE KLEYIPGEHE
FGLFPSPIHF NFLPCFVFSG KYLRQKRIDF QLPYDILWLW KHDQLYKRPD VPLYKKIRSN
VYVDVKPLSG YETTTCSCKQ REDSTEKGCL DECLNRMSYA ECSPSTCPSG DQCDNQHIQR
HDWVQCLERF RAEGKGWGIR TKETLRSGQF IIEYLGEVVS EQEFRSRMME QYFAHSGQYC
LNLDSGMVID SYRMGNEARF INHSCEPNCE MQKWSVNGVY RIGLFALKDI NSGIELTYDY
NFHSFNTEEQ QACKCGSESC RGIIGGKSQR INGLPGKTGG TRRLGRLKEK RKSKHQLKKR
VSEEESSDSN KFYPHLMKPM SNRERNFVLK HRVFLLRNWE KMREKQELLK REGERERDPG
SLSLYTRWGG VIRDDGNIKS DVFLTQFSAL QTSRSVRTRR LAAAEENTEV TRTARLAHIF
KEICDMITSY KDSAGQTLAA PLVNLPSRKR NSQYYEKVSD PLDLSTIEKQ ILTGHYKTVE
AFDTDMLKVF RNAEKYYGRK SSVGRDVCRL RKAYYSARHE AAVQIDEIVG ETASEADSSD
SLERDHGHHH GGGGPGPHDK DDDVIRCICG MYKDEGLMIQ CEKCMVWQHF DCMRLESEVE
HYLCELCDPR PVDREVPMIP QPSYAQAGSV YYICLLRDEL LLHQGDCVYL MRDSRRTPEG
QPVRQSYRLL SHVNRDKLDI FRIEKLWKNE KGERFAFGHH YFRPHETHHS PSRRFYQNEL
FRMPLYEIIP LEAVVATCCV LDLYTYCKGR PKGVKEQDVY ICDYRLDKSA HLFYKIHRNR
FPVCTKLYAF NHFPKRLAPK RDFSPHYVPD NYKRNGGRSA WKSDLPKGAA GCEDDDSPRE
RADDFPPEAE GGRGEEDDAD KNPDEPELSA KPRGAERERD GEGDEDEDEK EEEEEGQESE
ERDAQRDRLN KILLDLLYRS PNKNAIDVSY LLEEGAGRRL RRRALGFGDF VGRK
//
