ID G3NGB2_GASAC Unreviewed; 912 AA.
AC G3NGB2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Glutamate metabotropic receptor 4 {ECO:0000313|Ensembl:ENSGACP00000004367.1};
GN Name=GRM4 {ECO:0000313|Ensembl:ENSGACP00000004367.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000004367.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000004367.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000004367.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
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DR AlphaFoldDB; G3NGB2; -.
DR STRING; 69293.ENSGACP00000004367; -.
DR Ensembl; ENSGACT00000004381.1; ENSGACP00000004367.1; ENSGACG00000003323.1.
DR eggNOG; KOG1056; Eukaryota.
DR GeneTree; ENSGT01030000234648; -.
DR InParanoid; G3NGB2; -.
DR OMA; TDEMQWP; -.
DR TreeFam; TF313240; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000003323; Expressed in telencephalon and 1 other cell type or tissue.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd06376; PBP1_mGluR_groupIII; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR001786; GPCR_3_mGluR4.
DR InterPro; IPR000162; GPCR_3_mtglu_rcpt.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR24060:SF23; METABOTROPIC GLUTAMATE RECEPTOR 4; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01054; MTABOTROPC4R.
DR PRINTS; PR00593; MTABOTROPICR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00979; G_PROTEIN_RECEP_F3_1; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..912
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003448366"
FT TRANSMEM 587..613
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 625..644
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 656..672
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 751..772
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 784..806
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 826..848
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 587..861
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 912 AA; 101495 MW; 77D0A33AA6BEEA68 CRC64;
MTLRGGFERP WVGCCWVLLL ARCFSVAWAA KPKTPGHTHL NSVRIDGDIS LGGLFPVHAR
GNDGKACGEL KKEKGIHRLE AMLFALDRIN NDNELLPNIT LGARILDTCS RDTHALEQSL
TFVQALIEKD STDVKCLSGG PPIITKPERV VGVIGASASS VSIMVANILR LFKIPQVSYA
STAPELSDNT RYDFFSRVVP PDTYQAQAMV DIVKAMRWNY VSTVASEGNY GESGVDAFIQ
KSREDGGLCI SQSVKIPREP RTGEFDKIIR RLSENPNARV VIIFANEDDI RRLLQAAKKA
NQTGHFIWVG SDSWGSKISP ILNQEEMAEG AVTILPKRQS IKGFDRYFIS RTLENNRRNI
WFAEFWENNF QCKLSRHAVK KGSGIKKCTN HERIGKDSSY EQEGKVQFVI DAVYAMAHAL
HNMHKDLCPG RVGLCPKMET INGTLLLKYI RHVNFTGIAG TPVVFNVNGD APGRYEIYQY
QITNNTTEYK IIGNWTDQLH LDTDEMQWPG ATQEVPSSIC SQPCRPGQRK KTVKGIPCCW
HCENCDGYQY QADTYTCKMC RFDLRPNANN TACDPIPIVK LEWSSPWAVI PVLIAVLGIM
ATLFVVGSFV RYNDTPIVKA SGRELSYVLL TGIFLCYATT FLMISTPDVV ICSLRRIFLG
LGMSISYAAL LTKTNRIYRI FEQGKMSVSA PRFISPASQL VITFSLISVQ LLGVCIWFGV
DPSQAIIDYE DQRTANPKMA RGVLKCDISD LSLICLLGFS MLLMVTCTVY AIKTRGVPET
FNEAKPIGFT MYTTCIVWLA FIPIFFGTSQ SAEKMYIQTT TLTISVSLSA SVSLGMLYMP
KVYVVLFHPE QNVPKRKRSL KAVVTAATMS NKFNPKGGLR PNGEAKSELC ESLETQGLAS
KQTYISYSNH AT
//
