ID G3NGU6_GASAC Unreviewed; 826 AA.
AC G3NGU6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Villin-like {ECO:0000313|Ensembl:ENSGACP00000004553.1};
GN Name=VILL {ECO:0000313|Ensembl:ENSGACP00000004553.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000004553.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000004553.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000004553.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the villin/gelsolin family.
CC {ECO:0000256|ARBA:ARBA00008418}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; G3NGU6; -.
DR Ensembl; ENSGACT00000004567.1; ENSGACP00000004553.1; ENSGACG00000003464.1.
DR GeneTree; ENSGT00940000160253; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000003464; Expressed in intestinal epithelial cell and 2 other cell types or tissues.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0051693; P:actin filament capping; IEA:UniProtKB-KW.
DR GO; GO:0007010; P:cytoskeleton organization; IEA:InterPro.
DR CDD; cd11290; gelsolin_S1_like; 1.
DR CDD; cd11289; gelsolin_S2_like; 1.
DR CDD; cd11292; gelsolin_S3_like; 1.
DR CDD; cd11293; gelsolin_S4_like; 1.
DR CDD; cd11288; gelsolin_S5_like; 1.
DR CDD; cd11291; gelsolin_S6_like; 1.
DR Gene3D; 3.40.20.10; Severin; 6.
DR Gene3D; 1.10.950.10; Villin headpiece domain; 1.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR036180; Gelsolin-like_dom_sf.
DR InterPro; IPR007122; Villin/Gelsolin.
DR InterPro; IPR003128; Villin_headpiece.
DR InterPro; IPR036886; Villin_headpiece_dom_sf.
DR PANTHER; PTHR11977; VILLIN; 1.
DR PANTHER; PTHR11977:SF30; VILLIN-LIKE PROTEIN; 1.
DR Pfam; PF00626; Gelsolin; 6.
DR Pfam; PF02209; VHP; 1.
DR PRINTS; PR00597; GELSOLIN.
DR SMART; SM00262; GEL; 6.
DR SMART; SM00153; VHP; 1.
DR SUPFAM; SSF55753; Actin depolymerizing proteins; 4.
DR SUPFAM; SSF82754; C-terminal, gelsolin-like domain of Sec23/24; 2.
DR SUPFAM; SSF47050; VHP, Villin headpiece domain; 1.
DR PROSITE; PS51089; HP; 1.
PE 3: Inferred from homology;
KW Actin capping {ECO:0000256|ARBA:ARBA00022467};
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635}.
FT DOMAIN 760..826
FT /note="HP"
FT /evidence="ECO:0000259|PROSITE:PS51089"
SQ SEQUENCE 826 AA; 92200 MW; 5185BE7E73C20DCB CRC64;
MMDDDNQETF KNVSQKPGLQ IWTINNMQMV PVPAQGFGNF FEGDCYIILH ISQNKGSGQS
ADIHYWIGNS SSQDEQGAAA IYVTQLDEHL GGSPVQHRES QGNESAMFRS YFKNGLIYKK
GGVASGFHHV EPNVYNVLRL LHVKGRKHVT ATEVEVSWNS FNNGDIFLLD MGKAIVQWNG
PQSNKREKLK AVLLAQDVRD RERGGRAQIG VVEGGAERDS PELMKIMTAV LGQRSGQLKE
AVADDEPDQV QNASVRLYQV FENGGNLVVQ EVATQPLTQD LLHSSDCYIA DQGGSSVMVW
KGKQASKVER QEALNRALGY MKAKKYPQST SVDVMSEGGE SAMFKHLFKS WRDKGQTQGL
GATYNVGKIA KVDQVKFDVM ELHARPELAA QQRMVDDASG DVKVWRIEKL ELAEVNPNTY
GQFYGGDCYL VLYTYQISNQ QQYILYMWQG RHATKDEITA CAFQAVNVDN KYNGAPVQVR
VIMGKEPRHF LAIFKGKLII FEGGTGRPGV VNPERGPRLF QVRGTNELNT KATEVPSRAS
SLNTNDVFVL QTDHVCNLWY GKGCSGDERV MGRSVSEALS KQDKQVVMEG QEPAEFWVAL
GGKAPYACDK RLQREEPPHS PRLFECSNQT GCFRMTEVHD YAQSDLDEDD VMLLDTWEEI
FLWVGDSANE YETKEAWNSA QDYLRTHPAG RDTETPIVSV KQGYEPPTFT GWFGAWDPHK
WSGGNSYEEM TKKLSDPASL AQISVDLSNS FFNKSPASGG PGGMYLDPEI LINKSPSELP
QGVDPGSRED HLTDAAFENL LGTTRSDFKR LPKWRQSDLK KKAGLF
//
