ID G3NH03_GASAC Unreviewed; 1214 AA.
AC G3NH03;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Neurofascin {ECO:0000313|Ensembl:ENSGACP00000004610.1};
GN Name=NFASC {ECO:0000313|Ensembl:ENSGACP00000004610.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000004610.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000004610.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000004610.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily.
CC L1/neurofascin/NgCAM family. {ECO:0000256|ARBA:ARBA00008588}.
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DR AlphaFoldDB; G3NH03; -.
DR Ensembl; ENSGACT00000004624.1; ENSGACP00000004610.1; ENSGACG00000003505.1.
DR GeneTree; ENSGT00940000157024; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000003505; Expressed in diencephalon and 3 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 4.
DR Gene3D; 2.60.40.10; Immunoglobulins; 10.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR026966; Neurofascin/L1/NrCAM_C.
DR PANTHER; PTHR44170:SF12; NEUROFASCIN; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF13882; Bravo_FIGEY; 1.
DR Pfam; PF00041; fn3; 4.
DR Pfam; PF07679; I-set; 3.
DR Pfam; PF13927; Ig_3; 2.
DR SMART; SM00060; FN3; 4.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 5.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS50835; IG_LIKE; 6.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..1214
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003448356"
FT TRANSMEM 1084..1105
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 44..138
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 146..236
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 250..339
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 344..431
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 437..523
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 527..612
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 638..736
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 738..831
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 836..940
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 944..1040
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1122..1152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1122..1146
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1214 AA; 137543 MW; CBE015D60C3EF6BF CRC64;
TAAPPPPPMG TLVEPALLLL LWQSVWALDV PLERHASIKL RQPPTIIKQS MKDHIVDPKD
TMVIECEAKG NPHPIISFSW RRNGKYFNVA RDTQVSMRRR SGTLDIYAWN NPEQYEAEYQ
CIASNAYGSA YSNKIRLRLY RAPVWPREVL EPLVVSAGLP LVLSCDPPPG PPKPETYWMS
SSVPTMHPVR PDRRVSMGIN GDLYFSNVQF NDSAADYCCN ARFPYKNVIQ QKMPVVVKVL
TIRTVAEAAP TWLSPTGSSS SILVLQGEEL LLECIAAGVP TPRIAWTKNG DDLGASPRIK
VKNFNKMIQI QKASFDDVGE YTCTATNKIG YIEHTVTVRV KAAPFWLEKP TDLVLAPEEN
GRLLCQSDGA PRPTVSWFIN GEPIEVATPQ PNRQVSGDTL TLRAVTAENT AVYQCNVSNE
FGYLLANAFV NVLHATPRIL GARNELIKVI EGSRPLLDCR YFGSPVPELR WSKYGQGTLE
GNRFKTHRNG TLEIKQIRIE DQGTYLCVVS NVAGRDESQV RIEVKEPTLI VTRPQSMKVI
RGSDVRFECG VKTDVTTPVT TTWMKDKKHV TLGWSERISL DESNLVITNA NRGDEGNYTC
VIKSEMEQKS ASARLMVMDY NCQPNDTFGF LITDRPDPPT KLELSDPYER SVRLRWVPGE
SNHNPITEYL VQYDDDDWLP GKWRNLSTYP GNLNSVILHL TPFTYYEFRV IAINEIGMSR
PSRPSTRFQS SGAPPDVIPK NVKGVGTWRN NMEISWEPLT YRQWNGPHLK YLVWWKRRDS
REEWKNATTK WLKYYIYDAD TFTPYDIKVQ AVNDFGLGPE SPVVTGYSGE DRPLTAPLNL
RVSDIESTQV TLHWDSVTRG SMMGELKEYK AYYWRDSSQL GWLRVNRGMK SKAYPDNHPE
PSGVLTGLVP YSNYKLYIVV ANNRYEGPPS NNIVFSTPEG VPSAPRSFRI QQRHLDSIYV
DWDLPAEPNG VITGYSLKYQ TMNATRGEES RVEELTPNVT SFSVRRFDRY TRYRFSVAAQ
TRIGTGEWHT EESPHYTTES TSLPHTRWST KQTLLSGGWM LVLRVLVCFP AYAQDQVDIT
TQGWFIGIMC AVALMVLILL IVCFIKRSRG GKYPVREKKD ISMEPVDDKD QEGSFDYREE
ERGLQRGQSS MEAMMKRSDS DDSLVDYVEG SEIPFNEDGS FIGQYTGTRR DVRELDFGGT
LELHSSVNTI YSLA
//
