ID   G3NME7_GASAC            Unreviewed;      1033 AA.
AC   G3NME7;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 49.
DE   RecName: Full=MMS19 nucleotide excision repair protein {ECO:0000256|RuleBase:RU367072};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000006510.1, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000006510.1, ECO:0000313|Proteomes:UP000007635}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000006510.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC       (CIA) complex, a multiprotein complex that mediates the incorporation
CC       of iron-sulfur cluster into apoproteins specifically involved in DNA
CC       metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC       adapter between early-acting CIA components and a subset of cellular
CC       target iron-sulfur proteins. {ECO:0000256|RuleBase:RU367072}.
CC   -!- SUBUNIT: Component of the CIA complex. {ECO:0000256|RuleBase:RU367072}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle
CC       {ECO:0000256|RuleBase:RU367072}. Nucleus
CC       {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU367072}.
CC   -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC       {ECO:0000256|ARBA:ARBA00009340, ECO:0000256|RuleBase:RU367072}.
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DR   AlphaFoldDB; G3NME7; -.
DR   STRING; 69293.ENSGACP00000006510; -.
DR   Ensembl; ENSGACT00000006527.1; ENSGACP00000006510.1; ENSGACG00000004915.1.
DR   eggNOG; KOG1967; Eukaryota.
DR   GeneTree; ENSGT00390000015583; -.
DR   InParanoid; G3NME7; -.
DR   OMA; FSFMPEF; -.
DR   TreeFam; TF314469; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   Bgee; ENSGACG00000004915; Expressed in intestinal epithelial cell and 13 other cell types or tissues.
DR   GO; GO:0097361; C:CIA complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR039920; MET18/MMS19.
DR   InterPro; IPR024687; MMS19_C.
DR   InterPro; IPR029240; MMS19_N.
DR   PANTHER; PTHR12891; DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19; 1.
DR   PANTHER; PTHR12891:SF0; MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG; 1.
DR   Pfam; PF12460; MMS19_C; 1.
DR   Pfam; PF14500; MMS19_N; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|RuleBase:RU367072};
KW   Cytoskeleton {ECO:0000256|RuleBase:RU367072};
KW   DNA damage {ECO:0000256|RuleBase:RU367072};
KW   DNA repair {ECO:0000256|RuleBase:RU367072};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367072};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          50..308
FT                   /note="MMS19 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14500"
FT   DOMAIN          552..984
FT                   /note="MMS19 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12460"
SQ   SEQUENCE   1033 AA;  112377 MW;  0874D29B813588C0 CRC64;
     LGASHRGAMA ADSAVLLSLV EEFVSGLQDS KANDAATCVK DGQFTILELV EALGLSLTSS
     QPHTRARAVQ LLSQVLHDCH GALTEREVEV LLAFYENRLK DHYVITPPVL HGLRALTKCT
     VLPPGSAVSM LRSLFQDVHV QSLMLGERAC VYNMLINLMA TREAELKGLG ADFVFGFVQS
     MDGERDPRNL LLAFQIARTI VLRGYDLGKF TEELFEVTSC YFPIDFSPAP GDGEGGVLPK
     LRGVPPGTPR FWRLPLYFSL PLTIERLVSD VHRDTLLSVV AGVSKYEHKD VAEFLEGLWA
     SLRREVFQTA SEKIEAAGLA ALTALTSCLS RSVLNSDSED SLSTFLQLVL TDCKHHLCEP
     DLKLVWPSAK LLQAACAASS RASHTVADAV MPALIEQYNG RAQCSQRRTL LEVVQRFLQS
     VKTCESEESV FSAFRPALCT VVFSALTETN SSLQITAASV LTSLARHSDL LLDSDIELAV
     DHLTRLLLTE EDERVSLAVV ECAGALAELR SAAFITNLIP RLKKELFSEP TDQKDNSEAS
     EKLSHHAVRQ RCLSALAAVS TQPGVVQESA PVLLEVLGSA HAGGVVFSVE EVVAACGSLR
     RIAERVQDTE ETGRCFHDVI IPRLLSLALQ AALQGGGGSP GRRSPLLEEV VLAAMVPVIS
     TSCSRLQPTL AGQTAARAVS LFLDGDVSFL PDNSFPSNLQ LLKTQQGDSW SQSQMVCLLL
     GCVCSLPRTV EAPRLDELMT ELEEMSCACS HPLSYTSAAK CFAGLANKRA AGESLDGLIQ
     RTMKRVCSEL DCPSSPARTQ AFTLMIWVAK ALLLRYHPLY ATLTDKLFSL LDDADLGPAA
     ADAFLLLMSD TADILNRGCH ADVRIMYRQR FFSENSAKLV QGFNAAPQEK KPNYLKALSN
     IVNKLPKQVQ LTELPALLSL LLEALLCPDH AVQLSTLSCL EPVLMEPPPA LIQQLEALVG
     RLLALTASAV MSVRIASLRC IHSISCFPAH EVLPFRARVL RALSRPLDDH KRLVRREAVR
     ARAEWFLLGS PGG
//