ID G3NMK1_GASAC Unreviewed; 1224 AA.
AC G3NMK1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Dynactin subunit 1 {ECO:0000256|ARBA:ARBA00016574};
GN Name=DCTN1 {ECO:0000313|Ensembl:ENSGACP00000006564.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000006564.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000006564.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000006564.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the dynactin 150 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00011010}.
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DR AlphaFoldDB; G3NMK1; -.
DR Ensembl; ENSGACT00000006581.1; ENSGACP00000006564.1; ENSGACG00000004951.1.
DR GeneTree; ENSGT00940000155378; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000004951; Expressed in diencephalon and 3 other cell types or tissues.
DR GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1170.10; -; 1.
DR Gene3D; 2.30.30.190; CAP Gly-rich-like domain; 1.
DR InterPro; IPR036859; CAP-Gly_dom_sf.
DR InterPro; IPR000938; CAP-Gly_domain.
DR InterPro; IPR022157; Dynactin.
DR PANTHER; PTHR18916; DYNACTIN 1-RELATED MICROTUBULE-BINDING; 1.
DR PANTHER; PTHR18916:SF6; DYNACTIN SUBUNIT 1; 1.
DR Pfam; PF01302; CAP_GLY; 1.
DR Pfam; PF12455; Dynactin; 1.
DR SMART; SM01052; CAP_GLY; 1.
DR SUPFAM; SSF74924; Cap-Gly domain; 1.
DR PROSITE; PS00845; CAP_GLY_1; 1.
DR PROSITE; PS50245; CAP_GLY_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635}.
FT DOMAIN 31..73
FT /note="CAP-Gly"
FT /evidence="ECO:0000259|PROSITE:PS50245"
FT REGION 81..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 226..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 907..998
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 129..145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1224 AA; 135591 MW; 709A2AA7C6A6F4D4 CRC64;
MSSDGGGRPV KVGSPVEVIG KGQRGTVAYI GNTLFASGKW VGVILDEAKG KNDGTVQGKR
YFTCEENRGI FVRQSQIQLV DDGADTTSPE TPEAATGKVP KREILETPKS TKLPTRPAGG
KGAASGSASA SAGEMSSSEP STPAQTPLAA PVIPALHSPG NPPAPAPTKE EEALRGQVKD
LEEKLETLKM KRTEDKAKLK ELEKHKIQLE QLQEWKTKMQ EQQAELQKQL KEAKREAKEA
QEAKEHYMEE MSDTADAIEM ATLDKEMAEE RAESLQLEVD SHKEKVDELT MDLEILKHEI
EEKGSDGAAS SYHVKQLEEQ NGRLKEALVR MRDLSSSEKQ EHVKLQKQME KKNVELDTLR
AHKEKLQEEM AVAEKTIDEL KEQVDAALGA EEMVEMLTER NLDLEEKVRE MRETVTDLEA
INEMNDELQE NARETELELR EMLDLGAAKV RESGKHVEAA QETVADYQQT IKKYRELTAH
LQEVNRELTS QQEASAELQQ QAPAEMFDFK IKFAETKAYA KAIEMELRKM EVGQANRHVS
LLTSFMPESF LRHGGDHDCI LVLLLIPRLV CKAELISKQA QEKFELNENC VERAGLKGAV
GEQLSFAGGL VYSLSLLQAT LHKYEQALAQ CSVDVYKKVG ALYPEMSVHE RSLDFLIDLL
HKDQLDETVN VEPLTKAIKY YQHLYSIHLA DQDEDCTMQL ADHIRFTQSA LDCMAVEVGR
LRSFLHAGQE KADLAVLLKD LETSCSDIRQ FCKKIRRRMP GTDAPGIPAA LTFGQQVCDT
LSDCRKHLTW VVAVLQEVAA AGAQMVSPLG EQEGLSAVKL EDVAFKAGEQ IYGSQGADPY
ECLRHSCGMV IATMNKMATA MQEGEYDSER PQNKNPPPVD MRAAALRAEI TDAEGVGLKL
EDRETVIKEL KKALKIKGEE LSEASVRLSL LEKKLDSSSK DADERVEKIQ TRLDEAQTLL
KKKEKEFEET MDALQADIDQ LEAEKAELKQ RINSQSKMTV DGLRAAGPSG IASIVTGAAG
AANVMPVSGS GVQVIDSPLL TQQIEAQRLC IKHLKNDNNR MKAEKMRAQL ASLPPLHVTK
LPCREGGRPE VLSSALYRKT DQLLETLLQM SANVKVVDIT GKSPVTPGAQ LLEQTARLQS
LSDTLGRLKD EVAEHVVHQQ AGARVSSDFA TFPSTSFVKA KEEKQGDTVL VGRVMVPCHS
GQEQVHRLVL SQSQLHRVHS LLQT
//
