ID G3NN50_GASAC Unreviewed; 1065 AA.
AC G3NN50;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Unc-13 homolog D (C. elegans) {ECO:0000313|Ensembl:ENSGACP00000006763.1};
GN Name=UNC13D {ECO:0000313|Ensembl:ENSGACP00000006763.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000006763.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000006763.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000006763.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the unc-13 family.
CC {ECO:0000256|ARBA:ARBA00005823}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; G3NN50; -.
DR STRING; 69293.ENSGACP00000006763; -.
DR Ensembl; ENSGACT00000006780.1; ENSGACP00000006763.1; ENSGACG00000005106.1.
DR eggNOG; KOG1328; Eukaryota.
DR GeneTree; ENSGT00730000110939; -.
DR InParanoid; G3NN50; -.
DR OMA; ICKTKAF; -.
DR TreeFam; TF315526; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000005106; Expressed in head kidney and 4 other cell types or tissues.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR CDD; cd08676; C2A_Munc13-like; 1.
DR CDD; cd04009; C2B_Munc13-like; 1.
DR Gene3D; 1.10.357.50; -; 1.
DR Gene3D; 1.20.58.1100; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR010439; MUN_dom.
DR InterPro; IPR014770; Munc13_1.
DR InterPro; IPR014772; Munc13_dom-2.
DR PANTHER; PTHR45999:SF3; PROTEIN UNC-13 HOMOLOG D; 1.
DR PANTHER; PTHR45999; UNC-13-4A, ISOFORM B; 1.
DR Pfam; PF00168; C2; 3.
DR Pfam; PF06292; MUN; 1.
DR SMART; SM00239; C2; 2.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS51258; MHD1; 1.
DR PROSITE; PS51259; MHD2; 1.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635}.
FT DOMAIN 56..236
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 521..643
FT /note="MHD1"
FT /evidence="ECO:0000259|PROSITE:PS51258"
FT DOMAIN 755..865
FT /note="MHD2"
FT /evidence="ECO:0000259|PROSITE:PS51259"
FT DOMAIN 880..1009
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 1045..1065
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1045..1059
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1065 AA; 121715 MW; 2375695E5C1F17A3 CRC64;
KCSPKPSSHS VHFCSKLKPL YKELLYTITH RMGKPSSAEV FTESQLHQYI QEAFTMTEAE
HRSLMERVHG TEPPVYCLMA TVKEAKEILG KDISGFSDPY CLLTIMEDEE ESRTRRSKAK
PSKSIVKDVV SNDKIYESEI KKQTLNPIWN QTFILEFRDI AGASFHLEMW DKDEELSLTQ
KLEDIKTNFS SLKRMIKDAK KEKGQDDFLG KVVLKLQDLH CTEDNWYNLE PRTETYPNRG
KCHLNLKFIH KARDGTLSAG RSAYINYCGI LQQFVEAYIS KQKSSAPWKG ALCGEAQTLL
EFYASQNDLS PFLQDLAKWV AYSKLYQSLE VDSSVLFQQL TSVEYHWRQQ ELPHQQKQEL
GDSLHGFLQY GLCLVAKYRD IFPPTPSATP KLHTLLRILV QICKTQAFQK LNPAQFELHD
EVSDAIQTGT QEWFTLKKGL HQPMTKDLAE IVNALSRLIG EVQEDIKHNK DVWNRVFLSA
VQVDVFTVVY KRFDSLIAKE VRKTLSLLQG QMEQALANTL FPVYLSLQAI HKGVSTCGFR
GSLELTNFQE DFRDALPYWL NQAFSRTQER VERAVQVDQL QPLQSGAVPI KHSTSAVDLV
ACIQPICHLW EQLSWPDPEE AFMLMVKLTE DVCKIVVNYC HTLKERVRVL SENSDPGSAI
NMLCVVVNDL EHLRSVLNRL PTQLNWAGLR DRTQNVIGES QFHNTLPSQL QQAQSVLGRE
IRSALDTLGK KLNTDIETQV RNMSTRKRLP SKSTEDAAAP LMRYLEQELQ YMNENLVQEN
FNSLLTPLWN NSVKILYQVA TQHPQQGGLM VFCQRLLYTL QCLEQCFLAE GNGLPEKTLH
SDEYMALKAH LTHNSLSSCQ LIEKFLERKI QEQNVNTSEK YGAVTLLASY SRSDQRLRVE
VLNAVNLLPM DSNGLSDPFV QLCLEPNHVF QEVETRCTRT KSRDLNPLFE EAFEFLVSLD
QCRAPGACLV LTVLDHDTLM TDDFEGEAFL ALKGLPGVAR DMKGDELSLQ PEVTPAQIRL
PLIHPKHNDD SILALLESRR GEQEAQAYVK KRRQREKQSQ EGIQP
//
