ID   G3NNV8_GASAC            Unreviewed;       692 AA.
AC   G3NNV8;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 56.
DE   SubName: Full=Threonine synthase like 1 {ECO:0000313|Ensembl:ENSGACP00000007022.1};
GN   Name=THNSL1 {ECO:0000313|Ensembl:ENSGACP00000007022.1};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000007022.1, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000007022.1, ECO:0000313|Proteomes:UP000007635}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000007022.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933,
CC         ECO:0000256|PIRSR:PIRSR604450-51};
CC   -!- PATHWAY: Amino-acid biosynthesis. {ECO:0000256|ARBA:ARBA00029440}.
CC   -!- SIMILARITY: Belongs to the threonine synthase family.
CC       {ECO:0000256|ARBA:ARBA00005517}.
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DR   AlphaFoldDB; G3NNV8; -.
DR   STRING; 69293.ENSGACP00000007022; -.
DR   Ensembl; ENSGACT00000007040.1; ENSGACP00000007022.1; ENSGACG00000005308.1.
DR   eggNOG; KOG2616; Eukaryota.
DR   GeneTree; ENSGT00940000161144; -.
DR   InParanoid; G3NNV8; -.
DR   OMA; FNRCQHL; -.
DR   TreeFam; TF329641; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   Bgee; ENSGACG00000005308; Expressed in liver and 1 other cell type or tissue.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0008652; P:amino acid biosynthetic process; IEA:UniProtKB-KW.
DR   CDD; cd00464; SK; 1.
DR   Gene3D; 3.40.50.1100; -; 2.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.90.1380.10; Threonine synthase, N-terminal domain; 1.
DR   HAMAP; MF_00109; Shikimate_kinase; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000634; Ser/Thr_deHydtase_PyrdxlP-BS.
DR   InterPro; IPR031322; Shikimate/glucono_kinase.
DR   InterPro; IPR000623; Shikimate_kinase/TSH1.
DR   InterPro; IPR029144; Thr_synth_N.
DR   InterPro; IPR037158; Thr_synth_N_sf.
DR   InterPro; IPR004450; Thr_synthase-like.
DR   InterPro; IPR036052; TrpB-like_PALP_sf.
DR   NCBIfam; TIGR00260; thrC; 1.
DR   PANTHER; PTHR43515; THREONINE SYNTHASE-LIKE 1; 1.
DR   PANTHER; PTHR43515:SF1; THREONINE SYNTHASE-LIKE 1; 1.
DR   Pfam; PF01202; SKI; 1.
DR   Pfam; PF14821; Thr_synth_N; 1.
DR   PRINTS; PR01100; SHIKIMTKNASE.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF53686; Tryptophan synthase beta subunit-like PLP-dependent enzymes; 1.
DR   PROSITE; PS00165; DEHYDRATASE_SER_THR; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW   ECO:0000256|PIRSR:PIRSR604450-51};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635}.
FT   DOMAIN          190..274
FT                   /note="Threonine synthase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14821"
FT   MOD_RES         307
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR604450-51"
SQ   SEQUENCE   692 AA;  74838 MW;  102E3F340FAA4982 CRC64;
     RRSWLSTKAS PPGDQNILLM GAPGAGKTTV GRIVAHRLGL PVVDVDDDVL ETTWKMPVAS
     KLAAVGGERF VEEEGRALCN FSASGCVVSL TGSNPLHAAA MRRLKESGLV VYLDVDSEDV
     MRRLAGMKVN RIVGQEAGVS MRDILRYRKQ FYEKWLDVRV LCGAGATAEK VAEKVLKAVA
     RYRDHAAETF VSTRSDAAAA SEGRKRFSDV AIEGLAADGG LYVPKRGFPN MDAGEWRRLV
     DMSYPERALV LLEQCIHPSD VSAPELRKMT FEAYGSNFSS EAVAPVKHLV GNQYVQELFH
     GPTASFKDLA LQLMPRLFAH CLPPMCNYLV LVATSGDTGS AVLSGDPHRT GVLVFFPEEG
     VSETQKLQMT SRTEGNARAV GVLSDFDFCQ RSIKRMFGES GLTGHLAVEY ATVLSTANSI
     NWARLLPQVV FHSSAYLDLC RDGVIKFGDP VDVCIPTGNF GNAMSAVYAK QMGVPIRKVI
     CASNHNRVVA DFVATGEYDL RGRPLVPSYS PAIDILTSSN LERFVHHVSG GDGALVKELF
     AGLDGRRRFR LGGALLGRMQ REVAAGWCSE GDCLAAIRDV HAQTGYLMDP HTAAAKAVCD
     AVQDGSCPAV LCATAHYGKF APAAFQALRL RDVPEDPAEQ LRRLGSTASA PEMHGGLMGC
     LEETGRGPHA VRQADYGVLV EEVESMIRDS FL
//