ID G3NPE7_GASAC Unreviewed; 1975 AA.
AC G3NPE7;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000007211.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000007211.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000007211.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR STRING; 69293.ENSGACP00000007211; -.
DR Ensembl; ENSGACT00000007229.1; ENSGACP00000007211.1; ENSGACG00000005450.1.
DR eggNOG; KOG2301; Eukaryota.
DR GeneTree; ENSGT00940000163423; -.
DR InParanoid; G3NPE7; -.
DR OMA; KDFPKNG; -.
DR TreeFam; TF323985; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000005450; Expressed in heart.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:Ensembl.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR024583; Na_trans_cytopl.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF278; SODIUM CHANNEL PROTEIN TYPE 2 SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR Pfam; PF11933; Na_trans_cytopl; 1.
DR PRINTS; PR00170; NACHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|RuleBase:RU361132};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 130..147
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 159..178
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 198..216
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 228..245
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 251..273
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 386..413
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 739..757
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 769..792
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 849..877
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 939..962
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1192..1210
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1231..1250
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1262..1285
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1306..1334
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1432..1455
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1569..1588
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1622..1650
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 1726..1749
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 130..418
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 539..688
FT /note="Voltage-gated Na+ ion channel cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF11933"
FT DOMAIN 741..968
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 976..1186
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 1190..1464
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1513..1759
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 28..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 449..509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1029..1053
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1893..1912
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1925..1975
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 486..509
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1955..1975
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1975 AA; 223025 MW; BBE6591413022E8A CRC64;
KMAQLLAPPG PDSFRPLSRD SLKAIERRIA EEKAQKPKKE KRKRKDENKP KPSRELEAGK
SLPLLYGDAP KGMVSTPLED LDPFYCNQKT FIVLNRGNVI FRFNAAPALY LLSPFNLLRR
ISIKILVHSY PFTMFIMCTI LANCAYMTRS QDSAQWAKYV EYTFTAIYTL ESVIKILARG
FCIGKFTFLR DPWNWLDFSV IVLAYATALI PGLGNFSALR IFRVLRAFKA ISVIPGLKTI
VGALFQSVKK LVHVMILTVF CLSVFALIGL QLFMGHLKQK CVRIPNNDTS YNGTENGTFN
WETYKINSSN HYYLPGKRDP LLCGNGSEAG QCPDGFFCCK AGNNPDYNYT SFDSFGWAFL
SLFRLMTQDY WENLYQQTLR ASGKPYMIFF VLVIFLGSFY LINLILAVVA MAYEEQSQVT
IKEGIEKEEE FQAMLEQLKR QQEDAQFAAA TAAGAGEASD KVTGPESSSD TSKLSSKSAK
ERRNRRRKKK EEEGKGADEK VPKSGVNESR DGVWKGRCRF SVDANQLNYD MKCSSAHQSF
LSFRGPLFSS RRNSKTSLFS FRSQAQENGS DNEFADDENS IFEDNLSRRG SFFHPRSCDR
RSSSMSQRSF LSHLLFSPNG IKHSSVNCNG VVSLVGGNSL PSSPVGLLLP KADTTDTEYR
QAVGGTEQEF IDFLEGPEAR QRAYSIASVI TNTMEELEES RQKCPPCWYD FAHTFLIWDR
CPAWLKIKRI VKLIVMDPFG DLTITICIVL NTLFMAMEHY PMSPGFIQML NVGNLIFTSI
FTAEMVLKII ALDPYYYFQE KWNIFDAVIV GLSLIELCSS KPGSVSVLRS FRLLRVFKLA
KSWPTLNTLI KIIGNSVGAL GNLTLVLAII VFIFAVVGMQ LFGKRYEECV CKISADCTLP
RWHMKDFFHS FLIVFRVLCG EWIETMWDCM EVAGTHMCIT VYMMVMVIGN LVVLNLFLAL
LLSSFSADNL AAIEDDSEMN NLQIAIGRIR RGFAFTKSLL RNSCNSVCLR RKKKWKGEEN
SLDELHKTLG PNGVPNHTIK DFPKNGNGDV TGVDKTGDKY IVSSKSDDSI MSFINNPSLT
VTVPIAVGES DFENLNTEDF SSLSSDAAGC KVIVEDDGQL SSSDGSTVDL GPGGEGGESM
DFELDNSMVP DACFPDGCVK RFECCQVNAE VGWWKVWWKL RKTCFRIVEH NWFESFIIFM
ILLSSGALAF EDVYIAKRKN IQIVLQFADK IFTYIFILEM LLKWVAYGFA KYFTNAWCWL
DFLIVDVSLV TTVANALGYS DLGAIKSLRT LRALRPLRAL SRFDGMRVVV NALLGAIPSI
FNVLLVCLIF WLIFSIMGVN LLAGKYGHCV NRTSDMDFNT SEVKNKSDCD SLGKEIAIWK
IAKINFDNVG MGYLALLQVA TFKGWMDIMY PAVDSQSMAE EQPEYEINLK MYMYFVVFII
FGAFFTLNLF IGVIIDNFNQ QKKKFGGQDI FMTEEQKKYY NAMKKLGSKK PQKPIPRPSN
KIQGHIFDFT TKQAFEIIIM VLIWLNMVAM MVETDDQSAE TTEVLIFTGE CLLKMISLRH
YFFTNGWNVF DFIVVVLSII GMFLANLIEK YFVSPTLFRV IRLARIGRVL RLIKSAKGIR
TLLFALMMSL PALFNIGLLL FLVMFIYAIF GMSNFAYVKR ESGIDDLFNF ETFGNSMICL
FQITTSAGWD GLLAPILNNH EDDCNNSTEH PGSHIKGDCG NPPVGIAFFV SYIIICFLIV
VNMYIAVILE NFSVATEESA DPLSEDDFET FYEVWERFDP CATQFMEYDK LSEFADALDP
PLRIAMPNKM ELISMDLPMV SGERIHCLDI LFAFTKRVLG EGGEMDILRG QMEERFVASN
PSKLSYEPIT TTLLRKQEDT SATIIQRAFR RYSRKHAARS PSDTRGGNIQ KDVTLIDDGD
LVTGKLQDIS SDDKSEPTPS AVPQPPCNNV TTNGKNKYEK DKSEKEVEGK DVRER
//
