ID G3NWU0_GASAC Unreviewed; 1412 AA.
AC G3NWU0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000009809.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000009809.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000009809.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2B subfamily. {ECO:0000256|ARBA:ARBA00006396}.
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DR STRING; 69293.ENSGACP00000009809; -.
DR Ensembl; ENSGACT00000009829.1; ENSGACP00000009809.1; ENSGACG00000007392.1.
DR eggNOG; KOG4228; Eukaryota.
DR GeneTree; ENSGT00940000157151; -.
DR InParanoid; G3NWU0; -.
DR OMA; WLLFRTH; -.
DR TreeFam; TF312900; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000007392; Expressed in telencephalon and 4 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 1.
DR CDD; cd06263; MAM; 1.
DR CDD; cd14632; R-PTPc-U-1; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR000998; MAM_dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR24051:SF10; PROTEIN-TYROSINE-PHOSPHATASE-RELATED; 1.
DR PANTHER; PTHR24051; SUSHI DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF00629; MAM; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00020; MAMDOMAIN.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00409; IG; 1.
DR SMART; SM00137; MAM; 1.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00740; MAM_1; 1.
DR PROSITE; PS50060; MAM_2; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 727..750
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 3..165
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 167..258
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 265..360
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 470..570
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 880..1110
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1030..1101
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1142..1405
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1321..1396
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 804..831
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 804..819
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1412 AA; 158707 MW; D8E45EB96C932DDF CRC64;
PAAGCTFEED SDPSLCDFTQ GEEDDFDWLL LRTYGSPYAS PDLLRGSYML VNSSQHAVGQ
RAQLLLQTLS ENDTHCVQFS YFLYSRDGHS PGALRAYVRV NGGPLGSPVW NISGSHAKQW
HQVELAVSTF WPNEYQVLIE ATVSREQRGY IALDDIMVLN YPCYKAPHFS RLGDEEVNAG
QNATFQCVAA GRASEAEKFL LERHNGDIIT TASVKHLSHR RFVVSFQLDG VQRTDQDLYR
CVTQSPRGSG VSNFAELVVK VPPSPIAPPQ LLRAGSTYLI IQLNTNSILG DGPIIRKEIE
YRASQSPWSE VHGVNMVTYK LWHLDPDTEY HISVLLTRPG EGGTGPPGPP LVSRTKCAEP
MRALRGLAAP DIQPRQLSLQ WENLAFNLTR CHTYSVSLCY RYTTAGGGGG HNTTVRECLA
VEHNASRFTL RDLPPYHGIH VRLSLANPEG KKEGREVTFQ TEEDIPGGIA PESLTFTPLD
DMIFLKWEEP VEPNGLISQY EISYQSIESS DPGINVPGPR RTVSKLKNET YHMFSNLHPG
TTYLISVRAR TVKGFGLTAL TEITTNISAP MFDYGDMPSP LSETDSTITV LLRPAQGRGA
PVSTYQVVVE EETVKKVKRE LGLQDCFPLP MSHGEAQARG TPHYYTAELP PSSLPEASPF
TVGDNHTYNG YWNSPLDPRK SYLVYFQAMS NFRGESRINC IRIARKAACK DHRKALEVTQ
HSEEMGLILG VCAGGLVVLI LLLGAVIIII KKGKPVNMNK TPITYRQEKS NMGSMERSFT
DQSTLQEDER MALSFMDAHT CGTRSDARSS VNEASSLLGG SPRHQCGRKG SPYHTGQLHP
AVRVADLLQH INQMKTAEGY GFKQEYESFF DGWDCTKKKD KTKGRHDTMG YDRHRVKLHP
LLGDPNSDYI NANYIDGYHR SNHFIATQGP KQETLYDFWR MVWQENCFSI VMITKLVEVG
RVKCCKYWPD DSEMYGDIQI TLLKTETLAE YTVRTFALER RGYATKHEVR QFHFTSWPEH
GVPYHATGLL AFIRRVKAST PPDAGPVVVH CSVGAGRTGC YIVLDVMLDM AECEGVVDIY
NCVKTLCSRR INMIQTEEQY VFIHDAILEA CLCGETAILV NEFAVTYKEM LRVDSQSNSS
QLREEFQTLN SVTPHLDVEE CSIALLPRNR EKNRSMDVLP PDRALAFLVT TEGESNNYIN
AALADSFHRQ AAFIVTPHPL PGTTADFWRL VFDYGCTAVV MLNQLNQSNS AWPCVQYWPE
PGLQQYGPME VEFLSMSADE DVITRLFRVK NVTRLQEGQL VVCQFQFLRW SAYRDVPDSK
KAFLNLLAQV HKWQRECGEG RTVVHCLNGG GRSGTLCACN ILLEMIQYQN MVDIFYAVKT
LRNCKPNMVE SLDQYRFCYD LVLEYLDCFE GR
//
