ID G3NY70_GASAC Unreviewed; 1133 AA.
AC G3NY70;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=VWFA domain-containing protein {ECO:0000259|PROSITE:PS50234};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000010290.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000010290.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000010290.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR AlphaFoldDB; G3NY70; -.
DR STRING; 69293.ENSGACP00000010290; -.
DR Ensembl; ENSGACT00000010312.1; ENSGACP00000010290.1; ENSGACG00000007750.1.
DR eggNOG; KOG3637; Eukaryota.
DR GeneTree; ENSGT00940000154838; -.
DR InParanoid; G3NY70; -.
DR OMA; KGEAVWT; -.
DR TreeFam; TF105391; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000007750; Expressed in head kidney and 12 other cell types or tissues.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR048633; ITGAX-like_Ig_3.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF84; INTEGRIN ALPHA-L; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF21520; ITGAX-like_Ig_3; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR01185; INTEGRINA.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00191; Int_alpha; 4.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 2.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51470; FG_GAP; 2.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 23..1133
FT /note="VWFA domain-containing protein"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5001424625"
FT TRANSMEM 1086..1105
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT DOMAIN 141..317
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REPEAT 431..491
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 495..553
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ SEQUENCE 1133 AA; 123541 MW; 7907D621D8783482 CRC64;
IVTRIFLRLN ALLCFNIDPV AWKTLTEPAA GFGYQVVQRR SDLLVSAPLA QYSSSGRGQI
YKCTESCTKL SVPEAEFAVN MSLGLTMASD PSTQRTLACG PTIPKDCKSI TMYSGTCWQI
DNSDQVTGPV PSSIGDCRSA DVAFLLDGSG SVHASDFETM KTFVKDLVRS LPADTKFAIV
QFSSSPEIHY YFNDNLISGT GSWERKIDGI IQQEQLTYTA KAIRSVVNDV FTPTKGSRPN
VNKVLIVITD GESNDRDDLS SAASLADNKK IVRFAIGVGN AFNNEQAKKE LDTIASTKEN
VFQVKNFNAL DKIRQTLQAK LFSIEGSKTS GESLKLEMAQ EGFSAVYVPE GIQMAIVGAN
EWKGGFLQYS SSGLKTGSYE ADIETDSYLG YSMAVATTMY GTLTIVGAPR YKHRGAVMVV
HQNVLSFPLF IDNLSLSQFQ SGEYFGAVVC AMDVDLDSYT DLILISAPMF MDSDREGRVY
VCSLTGLDVE CRLDSPSVLR GEVSDKGRFG SSLAVLPDLN TDGLSDLAVG APLENNGQGS
IYIFHGEGGV GGGISSSYSQ RIAASEVRSS LRFFGLSISQ SSFDNSDDGL PELAIGSKGA
VVLLRSKPIV MVEATVSFSP NRISTQNSDC SNPLEITAEI CFTMTRRSKV DKGTRCSTVI
YDLTLDATRK VPNNRAYFNE KQRETKGTVQ IDLIRPVCNT VKYFVQACPE DALNALSNEL
RFAFEGLPIP PNPSPSLALQ AQKTTVHPLG FEINCGDDNN CVDDLKVDFN FTKSLEVKVG
IDELLDVTVS VENRGENSYN SRVIVSYPTG LSFRKFTPLQ VKRQDQFGRI ECSSLDSEDG
VTRGKTDCTV DKPILKSGSK AFFIISYGID TGSQLARSIS FSANVTSGNL DHSSSSKLYR
NKDIDVKYSI FATIESSLSY SNFSFGKNNL HKPVQQSIVV TNDIRALNFT VVIRVPVRLG
DKDIWADSSS LQIPDCQRGF DEQPKGTGFI GEIQKNKSVD CSVATCTVFK CSKLMGRLES
KTYQISANLS SEWIEQISTA SLEYDSKQYI FFSTGSYNNP PVHKHFTVQI EAEVEVYAEP
DFTKEIVGGS LGGLALLVLL TAGLYKAGFF KSKYKEMIND NAADPGDDGD AVT
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