ID G3NZM6_GASAC Unreviewed; 465 AA.
AC G3NZM6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=Chimaerin {ECO:0000256|PIRNR:PIRNR038015};
DE AltName: Full=Chimerin {ECO:0000256|PIRNR:PIRNR038015};
GN Name=CHN2 {ECO:0000313|Ensembl:ENSGACP00000010799.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000010799.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000010799.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000010799.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: GTPase-activating protein for p21-rac.
CC {ECO:0000256|PIRNR:PIRNR038015}.
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DR AlphaFoldDB; G3NZM6; -.
DR STRING; 69293.ENSGACP00000010799; -.
DR Ensembl; ENSGACT00000010821.1; ENSGACP00000010799.1; ENSGACG00000008146.1.
DR eggNOG; KOG1453; Eukaryota.
DR GeneTree; ENSGT01030000234635; -.
DR InParanoid; G3NZM6; -.
DR OMA; HCKTIFA; -.
DR TreeFam; TF342052; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000008146; Expressed in liver and 9 other cell types or tissues.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:UniProtKB-UniRule.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd20857; C1_betaCHN; 1.
DR CDD; cd04372; RhoGAP_chimaerin; 1.
DR CDD; cd10352; SH2_a2chimerin_b2chimerin; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR035840; Chimaerin_SH2.
DR InterPro; IPR017356; CHN1/CHN2.
DR InterPro; IPR020454; DAG/PE-bd.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR037860; RhoGAP_chimaerin.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR PANTHER; PTHR46075:SF4; BETA-CHIMAERIN; 1.
DR PANTHER; PTHR46075; CHIMERIN FAMILY MEMBER; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00017; SH2; 1.
DR PIRSF; PIRSF038015; N-chimaerin; 1.
DR PRINTS; PR00008; DAGPEDOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW GTPase activation {ECO:0000256|PIRNR:PIRNR038015};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRNR:PIRNR038015};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 59..127
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 211..261
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 274..465
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 465 AA; 53433 MW; 653A3941CF2820A0 CRC64;
MAASSNSSLS GSSLSSDPED YQPPIWKSYL YQLQQEAPRP KRITCPQEME NRPKYYGREF
HGMISRQYAD ELLAGAEGAY LIRESQRQPG THTLALSFGH QTLNYRLFYD GKHFVGEKRF
ESVHDLVTDA LITLYIETKA AEYIAKMTTN PIYEHLGYTS LLKDKMVHRL SRGRTEPRRV
TFQRDEKISS PLVRRSALKD TPEKQCSYEK IHNFKVHTFR GPHWCEYCAN FMWGLIAQGV
RCSDCGLNVH KQCSKLVPSD CQPDLRRIKK VFSCDLTTLV KAHNTTRPMV VDMCIREIEL
RGMQSEGLYR VSGFSEHVEE VRLAFDRDGE KADISAVAYA DINIIAGALK LYLRDLPIPI
ITFDLYSKFI QAAKIPNAES RLEGIHESLL QLPPAHFETL RYLMAHLKRV TQFEKDNFMN
AENLGIVYGP TLMQPPEQNA LTTLNDMRQQ KLVVQLMIEH EDVLF
//
