ID   G3P180_GASAC            Unreviewed;       842 AA.
AC   G3P180;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 53.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000011353.1, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000011353.1, ECO:0000313|Proteomes:UP000007635}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000011353.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC       multimeric enzyme that catalyzes the translocation of protons across
CC       the membranes. Required for assembly and activity of the V-ATPase.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR   AlphaFoldDB; G3P180; -.
DR   STRING; 69293.ENSGACP00000011353; -.
DR   Ensembl; ENSGACT00000011376.1; ENSGACP00000011353.1; ENSGACG00000008553.1.
DR   eggNOG; KOG2189; Eukaryota.
DR   GeneTree; ENSGT00950000182881; -.
DR   InParanoid; G3P180; -.
DR   OMA; IFYKWIS; -.
DR   TreeFam; TF300346; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   Bgee; ENSGACG00000008553; Expressed in camera-type eye and 13 other cell types or tissues.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629:SF91; V-TYPE PROTON ATPASE SUBUNIT A; 1.
DR   PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW   ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM        401..425
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        445..464
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        546..567
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        573..597
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        638..662
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        774..798
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   COILED          94..121
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   842 AA;  96461 MW;  58787FA0304ABE39 CRC64;
     MGELFRSEEM TLAQLFLQSE AAYCCVSELG EIGMVQFRDL NPDVNVFQRK FVNEVRRCEE
     MDRKLRFVEK EIKKANIPMV DTGENPEVPF PRDMIDLEAT FEKLENELKE INTNQEALKK
     NFLELTELKH ILRRTQQFFD EMEDPSVLDE SNTLLDPNEP QRVAPLRLGF VAGVIGRERI
     PTFERMLWRV CRGNVFLKQA EIEDPLEDPI TSDQVHKSVF IIFFQGDQLK NRVKKICEGF
     RATLYPCPET RQERKEMLAG VNARIEDLQM VLNQTEDHRQ RVLQAAAKTV RVWFIKVRKM
     KAIYHTLNLC NIDVTQKCLI AEVWCPVSDM DSIQFALRRG TEKSGSTVPS ILNRMQTKQP
     APTFNKTNKF TSGFQNIVDA YGIGSYREIN PAPYTIITFP FLFAVMFGDM GHGVLMTCAA
     LYLVLRESRL MAQKNDNEMF SMVFAGRYII LLMGVFSVYT GIIYNDCFSK SLNVFGSGWS
     VRPMFTSRLG GGNWTFETLR GNKVLQLDPT VDGVFKGPYP IGIDPIWNIA TNKLTFLNSF
     KMKMSIILGV IHMLFGVSLG LFNHLYFKKP LNIYLGFIPE IVFMASLFGY LAILIFYKWL
     SYDARISKDA PSLLIAFINM FLFNYNDPSN KPLYTGQMVI QSLLVIIALA CVPCMLIVKT
     LVLRRQHLWR KNLGRENFGG IRVGNGPTED EAQIIQHDQL SQHSEEEPEA CEEEEFNFGD
     VAVHQAIHTI EYCLGCISNT ASYLRLWALS LAHAQLSEVL WTMVMHIGLS TSGFAGFLVV
     TIVFFFFAIL TVAILLIMEG LSAFLHALRL HWVEFQNKFY SGQGFKFLPF TFESILEGRF
     ED
//