ID G3P2Q1_GASAC Unreviewed; 1098 AA.
AC G3P2Q1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Small G protein signaling modulator 1a {ECO:0000313|Ensembl:ENSGACP00000011874.1};
GN Name=SGSM1 {ECO:0000313|Ensembl:ENSGACP00000011874.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000011874.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000011874.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000011874.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RUTBC family.
CC {ECO:0000256|ARBA:ARBA00034124}.
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DR AlphaFoldDB; G3P2Q1; -.
DR STRING; 69293.ENSGACP00000011874; -.
DR Ensembl; ENSGACT00000011898.1; ENSGACP00000011874.1; ENSGACG00000008977.1.
DR eggNOG; KOG1648; Eukaryota.
DR GeneTree; ENSGT00940000156871; -.
DR InParanoid; G3P2Q1; -.
DR OMA; EKWLAMH; -.
DR TreeFam; TF318216; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000008977; Expressed in telencephalon and 5 other cell types or tissues.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProt.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR CDD; cd15784; PH_RUTBC; 1.
DR Gene3D; 1.20.58.900; -; 1.
DR Gene3D; 2.30.29.230; -; 1.
DR Gene3D; 1.10.8.270; putative rabgap domain of human tbc1 domain family member 14 like domains; 1.
DR Gene3D; 1.10.472.80; Ypt/Rab-GAP domain of gyp1p, domain 3; 1.
DR InterPro; IPR000195; Rab-GAP-TBC_dom.
DR InterPro; IPR035969; Rab-GAP_TBC_sf.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR037745; SGSM1/2.
DR InterPro; IPR021935; SGSM1/2_RBD.
DR PANTHER; PTHR22957:SF187; SMALL G PROTEIN SIGNALING MODULATOR 1; 1.
DR PANTHER; PTHR22957; TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF12068; PH_RBD; 1.
DR Pfam; PF00566; RabGAP-TBC; 1.
DR Pfam; PF02759; RUN; 1.
DR SMART; SM00593; RUN; 1.
DR SMART; SM00164; TBC; 1.
DR SUPFAM; SSF140741; RUN domain-like; 1.
DR SUPFAM; SSF47923; Ypt/Rab-GAP domain of gyp1p; 2.
DR PROSITE; PS50826; RUN; 1.
DR PROSITE; PS50086; TBC_RABGAP; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007635}.
FT DOMAIN 36..190
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT DOMAIN 562..1031
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000259|PROSITE:PS50086"
FT REGION 225..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 394..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 636..790
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 829..873
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 636..681
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 703..742
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 750..776
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 841..857
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 858..873
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1098 AA; 123862 MW; 84D1D21B8E7EBC5F CRC64;
VCVVFLEADT RQRLLRTVKK EVKQIMEESV TRKFVHEDSS HIVSFCAAVE ACVLHGLKRR
AAGFLRSNKI AALFMKVGKS FIPAEELCRK AQDLEQIIDS KRSQSLQSQD SIRKMPRLPS
FTQQGVKNLW IRTALFEKVL DKIVLYLVEN SSKYYEKEAV LMDPVDGPIL ASLLVGPCAL
EYTKMKTADH FWTDPSADEL VQRHRIHGGN CRQDSPTKRP ALCIQKRHSS SSMDERPSPS
PSAREYVESL HQNSRVTLLF GKNNVLVQPR DDMEAIPGYL SLHQNADLMT LKWTPNQLMN
GSVGDLDYER SVYWDYAITI PLGEIVYLHC HQQVDSGGTV VLVSQDGIQR PPLRFPRGGH
LLQFLSCLEN GLLPHGQLDP PLWSQRGKGK VFPKLRNRVP QGSGSSDSVS DKEEDEATDY
VFRILFPNSQ SEFVTPPDLM DHGATLWHPT LRKSSCSSCS QGSFSDGATP KGCNYERAPL
KLLCDNMKNQ IISRAFYGWL AYCRHLSTVR THLSALVNHT IVAPEVPCDA YKGLTTDVWQ
TFLQDCTAYD ENELLRLVYF GGVDASLRKE VWPFLLGHYQ FGMSEARRKE VDERVRVCYQ
QTMREWLGCE EIVRQREKEQ HAVALAKCSS VVSMDSSSQK ITHHNSTVSN ESQSPQSSDR
QSLARLQSDS SSSTQVFESV EEVDQIETEP KSEEAKQGPK LPNGAMQNET SSPDSGHPSS
RNFSVTSGLS DGSLSTEDSA AADTIPRSAA APQAPQSQVK PAEIQSEGST GEPVKQSPKT
AVEESLEKTL KLDYKNPEVE KKLDFSAGSG VARPREAYFA SQTGKAQAMT ESVTKPAACE
EPESESLDPH FDSLAESGHT KNEATSQPSA GSPFSQELLD LYTLNLHRIE KDVQRCDRNY
CYFTPANLEK LRNVMCSYIW RHLDIGYVQG MCDLLAPLLV ILDDEAMAFS CFTELMKRMN
QNFPHGGAMD THFANMRSLI QILDSELFEL MHQNGDYTHF YFCYRWFLLD FKRELVYDDV
FAVWETIWAA KCVSSGHFVL FIALALVEIY RDIILENNMD FTDIIKFFNE MAEHHNIKRI
LTMARDLVCK VQMLIENK
//
