ID   G3P2Y6_GASAC            Unreviewed;       365 AA.
AC   G3P2Y6;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 52.
DE   RecName: Full=Hydroxylysine kinase {ECO:0000256|ARBA:ARBA00040505};
DE            EC=2.7.1.81 {ECO:0000256|ARBA:ARBA00038873};
GN   Name=HYKK {ECO:0000313|Ensembl:ENSGACP00000011959.1};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000011959.1, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000011959.1, ECO:0000313|Proteomes:UP000007635}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000011959.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Catalyzes the GTP-dependent phosphorylation of 5-hydroxy-L-
CC       lysine. {ECO:0000256|ARBA:ARBA00037368}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(5R)-5-hydroxy-L-lysine + GTP = (5R)-5-phosphooxy-L-lysine +
CC         GDP + H(+); Xref=Rhea:RHEA:19049, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:37565, ChEBI:CHEBI:57882, ChEBI:CHEBI:58189,
CC         ChEBI:CHEBI:58357; EC=2.7.1.81;
CC         Evidence={ECO:0000256|ARBA:ARBA00036820};
CC   -!- SIMILARITY: Belongs to the aminoglycoside phosphotransferase family.
CC       {ECO:0000256|ARBA:ARBA00006219}.
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DR   AlphaFoldDB; G3P2Y6; -.
DR   STRING; 69293.ENSGACP00000011959; -.
DR   Ensembl; ENSGACT00000011983.1; ENSGACP00000011959.1; ENSGACG00000009062.1.
DR   eggNOG; ENOG502QT7T; Eukaryota.
DR   GeneTree; ENSGT00390000011314; -.
DR   InParanoid; G3P2Y6; -.
DR   OMA; AAHSCQL; -.
DR   TreeFam; TF324471; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   Bgee; ENSGACG00000009062; Expressed in intestinal epithelial cell and 5 other cell types or tissues.
DR   Gene3D; 3.90.1200.10; -; 1.
DR   InterPro; IPR002575; Aminoglycoside_PTrfase.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   PANTHER; PTHR21064:SF1; HYDROXYLYSINE KINASE; 1.
DR   PANTHER; PTHR21064; UNCHARACTERIZED; 1.
DR   Pfam; PF01636; APH; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635}.
FT   DOMAIN          36..274
FT                   /note="Aminoglycoside phosphotransferase"
FT                   /evidence="ECO:0000259|Pfam:PF01636"
SQ   SEQUENCE   365 AA;  41404 MW;  C40CE504E032739B CRC64;
     CFHSTAIMAT LHSKPNFSHA QVVEMVTRLF SLTPSEIRPL PSYDDQNFYV SCMEGGEYVL
     KIMNSEDSKN PSMIEVQTYA MSVLHQNGLP AQTALRNAAG QLMSLEEMDC GNGVRKYLVR
     LLTYLPGTTI SKVPLTPQLL YETGKMAARM DQILQKMEHP HLGLLERENF IWSLSNVLQL
     EAHLNILEGD PLEEVVKSVI HQYKTSVTPK RSNFRKCINH GDFNDLNVLV QPDESDGHRI
     SGILDFGDMN SGYYIHELAI AIMYMMTEHP EPVEVGGPVL AGWESVLPLN ETERDCLYVL
     VLSRFCQSMV LARHTVRMHP ENAEYLMISS RRGVHILRQL WELGKEQVEK VWFQSAGVHF
     SDIAI
//