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Database: UniProt
Entry: G3P3N9_GASAC
LinkDB: G3P3N9_GASAC
Original site: G3P3N9_GASAC 
ID   G3P3N9_GASAC            Unreviewed;      2241 AA.
AC   G3P3N9;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   24-JAN-2024, entry version 69.
DE   RecName: Full=acetyl-CoA carboxylase {ECO:0000256|ARBA:ARBA00013058};
DE            EC=6.4.1.2 {ECO:0000256|ARBA:ARBA00013058};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000012212.1, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000012212.1, ECO:0000313|Proteomes:UP000007635}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000012212.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=biotin; Xref=ChEBI:CHEBI:57586;
CC         Evidence={ECO:0000256|ARBA:ARBA00001953};
CC   -!- PATHWAY: Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from
CC       acetyl-CoA: step 1/1. {ECO:0000256|ARBA:ARBA00004956}.
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DR   STRING; 69293.ENSGACP00000012212; -.
DR   Ensembl; ENSGACT00000012236.1; ENSGACP00000012212.1; ENSGACG00000009222.1.
DR   eggNOG; KOG0368; Eukaryota.
DR   GeneTree; ENSGT00940000155049; -.
DR   InParanoid; G3P3N9; -.
DR   OMA; TEHCKVA; -.
DR   TreeFam; TF300061; -.
DR   UniPathway; UPA00655; UER00711.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   Bgee; ENSGACG00000009222; Expressed in intestinal epithelial cell and 13 other cell types or tissues.
DR   GO; GO:0003989; F:acetyl-CoA carboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:2001295; P:malonyl-CoA biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd06850; biotinyl_domain; 1.
DR   Gene3D; 2.40.50.100; -; 1.
DR   Gene3D; 3.40.50.20; -; 1.
DR   Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 1.
DR   Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR   Gene3D; 2.40.460.10; Biotin dependent carboxylase carboxyltransferase; 1.
DR   Gene3D; 3.90.1770.10; PreATP-grasp domain; 1.
DR   InterPro; IPR049076; ACCA.
DR   InterPro; IPR049074; ACCA_BT.
DR   InterPro; IPR034733; AcCoA_carboxyl_beta.
DR   InterPro; IPR013537; AcCoA_COase_cen.
DR   InterPro; IPR011761; ATP-grasp.
DR   InterPro; IPR013815; ATP_grasp_subdomain_1.
DR   InterPro; IPR005481; BC-like_N.
DR   InterPro; IPR001882; Biotin_BS.
DR   InterPro; IPR011764; Biotin_carboxylation_dom.
DR   InterPro; IPR005482; Biotin_COase_C.
DR   InterPro; IPR000089; Biotin_lipoyl.
DR   InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR011763; COA_CT_C.
DR   InterPro; IPR011762; COA_CT_N.
DR   InterPro; IPR016185; PreATP-grasp_dom_sf.
DR   InterPro; IPR011054; Rudment_hybrid_motif.
DR   InterPro; IPR011053; Single_hybrid_motif.
DR   PANTHER; PTHR45728:SF1; ACETYL-COA CARBOXYLASE 2; 1.
DR   PANTHER; PTHR45728; ACETYL-COA CARBOXYLASE, ISOFORM A; 1.
DR   Pfam; PF08326; ACC_central; 1.
DR   Pfam; PF21385; ACCA_BT; 1.
DR   Pfam; PF02785; Biotin_carb_C; 1.
DR   Pfam; PF00289; Biotin_carb_N; 1.
DR   Pfam; PF00364; Biotin_lipoyl; 1.
DR   Pfam; PF01039; Carboxyl_trans; 1.
DR   Pfam; PF02786; CPSase_L_D2; 1.
DR   SMART; SM00878; Biotin_carb_C; 1.
DR   SUPFAM; SSF52096; ClpP/crotonase; 2.
DR   SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR   SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR   SUPFAM; SSF51246; Rudiment single hybrid motif; 1.
DR   SUPFAM; SSF51230; Single hybrid motif; 1.
DR   PROSITE; PS50975; ATP_GRASP; 1.
DR   PROSITE; PS50979; BC; 1.
DR   PROSITE; PS00188; BIOTIN; 1.
DR   PROSITE; PS50989; COA_CT_CTER; 1.
DR   PROSITE; PS50980; COA_CT_NTER; 1.
DR   PROSITE; PS00866; CPSASE_1; 1.
DR   PROSITE; PS00867; CPSASE_2; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00409}; Biotin {ECO:0000256|ARBA:ARBA00023267};
KW   Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598};
KW   Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00409}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635}.
FT   DOMAIN          42..544
FT                   /note="Biotin carboxylation"
FT                   /evidence="ECO:0000259|PROSITE:PS50979"
FT   DOMAIN          197..392
FT                   /note="ATP-grasp"
FT                   /evidence="ECO:0000259|PROSITE:PS50975"
FT   DOMAIN          1479..1809
FT                   /note="CoA carboxyltransferase N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50980"
FT   DOMAIN          1813..2129
FT                   /note="CoA carboxyltransferase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50989"
SQ   SEQUENCE   2241 AA;  252691 MW;  D395625ED7DF3FC0 CRC64;
     RPSMSGLHLV KKGHNHRKMD VQRDFAVASP AEFVTRFGGN RVIEKVLIAN NGIAAVKCMR
     SIRRWSYEMF RNERTIRFVV MVTPEDLKAN AENTLNADHY VPVPGGPNNN NYDNVELIVD
     IAKRIPVQAV WAGWGHASEN PKLPELLDKA GVLFLGPSSK AMWALGDKVA SSIVAQSADI
     PTLPWSGSGL TVAWEEDDQF QGNMISVPPE IYTKGCVRDV DDGLAWAEKI GYPVVIKASE
     GGGGKGIRTV ENYEDFPSLY RQVQTEVPGS PIFIMQLAQH ARHLEVQILA DEYGNAISLF
     GRDCSIQRRH QKIIEEAPAT IASPSTFEQM EQYAVRMAKM VGYVSAGTVE YLYSEDGGFH
     FLELNPRLQV EHPCTEMIGD VNLPAAQLQI AMGIPLHRIK DIRLLYGETP WGDTLINFEA
     PECTPSPRGH VIAARITSEN PDEGFKPSSG TVQELNFRSS KNVWGYFSVG ATGGLHEFAD
     SQFGHCFSWG ENREEAISNM VVAMKELSIR GDFRTTVEYL IKLLETESFR NNDIDTSWLD
     HLIAEKVQAE RPDTMLGIVC GALHVADASF QKSMSDFLHS LERGQVLPAA SLLNSVNVDL
     IYEGVKFCLK VARQSPTTFV IMMNNSNIEI DVHRLSDGGL LLSYDGSSHI TYMKEEVDSY
     RITVSNKTCV FEKETDPTML RSPTAGKLLH YAVDDGGHVL SGEIYAEIEV MKMVMALTVQ
     QSGCVHFVKR AGAVLTPGCV VARLALDDPS SIHLVELNTA VLPPQQPLPT VGEKLHQVFH
     CVLENLVKVM AGYCLEDPFF SSKLKQWVST LMKTLRDPSL PLLELQDIIT SLASRIPPSV
     EKDIRKVMAQ YASNITSVLC QFPSQRIANI LDSHAATLQR KSDREVFFMN TQSIVQLVQR
     YRSGIRGYMK SVVLDLLKKY LQVEIQFQQA HYDKCVINLR EQHKPDMSPV LEYIFSHAQV
     SKKNILVIML IDQLCGKDSM LADELMDILN ELTQLSKMEN SKVALRARQV LIASHLPSYE
     LRHNQVESIF LSAIDMYGHQ FCPENLKKLI LSETSIFDVL PNFFYHSNQV VCMAALEVYV
     RRGYIAYELN SIQHQQLHDG TCAVDFQFML PSSHPNRVPV PVSGSSQFKM RRESSELFLE
     GAFSPPCQRM GAMVAFQCFE DFKRNFDEVL SSFAEPLLES APFSESCPSL FEEENFKNTR
     ENPIHIINVS IKNADTEDDD ALVTAFTAFA QSKRPILFEY GIRRITFLVA QKREFPKFFT
     FRARDGFQED QIYRNLEPAL AFQLELNRMR NFYLTAVPCA NHKMQLYLGA ARVQEGVEVT
     DYRFFIRAII RHSDLITKEA SFEYLQNEGE RLLLEAMDEL EVAFSNTGVR TDCNHIFLNF
     VPTVIMDPSK IEESVRSMVM RYGSRLWKLR VMQAELKINI RLTPTGNAIP VRLFLTNESG
     YYLDISLYNE VTNPSSGQIM FQSYGDKQGP LHGMLINTPY VTKDLLQAKR FQAQTLGTTY
     VYDFPEMFRQ ALFKLWGPGE KYPKDVLMCT ELVVDPEGQL VQMNRLPGDN DVGMVAFKMT
     MKTPEYPEGR DLVVICNDIT HMIGSFGPQE DELFLRASEL ARAEGIPRIY VAANSGARIG
     LAEEVKHMFQ VAWIDPTDPY KGFKYLYLTP QDYTCVSATN SVHCRHVEEG GESRYIITDI
     IGKDDGLGVE NLRGSGAIAG ETSQAYEEII TISMVTCRAI GIGAYLVRLG QRVIQVENSH
     IILTGAGALN KVLGREVYAS NNQLGGIQIM HNNGVTHTTV PDDFEGVFTV LKWLSYMPKN
     KHSPVPIIAT ADPVDREIEY TPTKAPYNPR WMLAGRPHPT VRGSWQSGFF DHGSFMEIME
     SWAQTVVVGR ARLGGIPLGV IAVETRTVEF TVPADPANLD SESKVLQQAG QVWFPDSAFK
     TAQAICDFNR EHLPLMVFAN WRGFSGGMKD MYDQILKFGA YIVDALRGFR QPVLVYIPPH
     AELRGGSWVV IDPTINPLCM ELYADRESRG GVLEAEGTVE IKFRRKDLLK TMRRLDSVYA
     SLVEQLASPE LPDKQGRELE TKLKAREEFL LPIYHQVAVQ FADLHDTPGR MQEKGVITDI
     LEWKNVRTFF YWRLRRLLLE QVVKCEILEA NKDLSDGHMQ SMLRRWFVET EGTVKAYLWD
     NNKEVVEWLE KHLTKEDGIR SGIRENIKYL KRENTLKHIR SVVEASPDIA MDCIIQMSQN
     ITPSQRAKLS HLLATMDSAS T
//
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