ID G3P558_GASAC Unreviewed; 862 AA.
AC G3P558;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=CARMIL C-terminal domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000012731.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000012731.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000012731.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the CARMIL family.
CC {ECO:0000256|ARBA:ARBA00007298}.
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DR AlphaFoldDB; G3P558; -.
DR STRING; 69293.ENSGACP00000012731; -.
DR Ensembl; ENSGACT00000012755.1; ENSGACP00000012731.1; ENSGACG00000009644.1.
DR eggNOG; KOG4242; Eukaryota.
DR GeneTree; ENSGT00940000155112; -.
DR InParanoid; G3P558; -.
DR OMA; QEMDRSA; -.
DR TreeFam; TF316381; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000009644; Expressed in zone of skin and 6 other cell types or tissues.
DR Gene3D; 6.10.140.1850; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR031943; CARMIL_C.
DR InterPro; IPR041245; CARMIL_PH.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR24112:SF39; F-ACTIN-UNCAPPING PROTEIN LRRC16A; 1.
DR PANTHER; PTHR24112; LEUCINE-RICH REPEAT, ISOFORM F-RELATED; 1.
DR Pfam; PF17888; Carm_PH; 1.
DR Pfam; PF16000; CARMIL_C; 1.
DR Pfam; PF13516; LRR_6; 2.
DR SMART; SM00368; LRR_RI; 6.
DR SUPFAM; SSF52047; RNI-like; 2.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635}.
FT DOMAIN 28..120
FT /note="CARMIL pleckstrin homology"
FT /evidence="ECO:0000259|Pfam:PF17888"
FT DOMAIN 784..862
FT /note="CARMIL C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16000"
SQ SEQUENCE 862 AA; 94702 MW; CA5C13326641C4D9 CRC64;
FVCGSHVVSL RVAESVRDAA GRGVKLTLGR RVQLEVKGDK LESRVLALAT HRAYLLTARV
PAKVEHSFSY LEIQGIRNKT EDLQLVLESE RGPWSLRLGS VDEVDEVIAH IGSSLQRICP
ACSRSKSMKK LSLKPPERTA SLQAAWDEQA SADVGPCGGF SHQYWCVCDY LGLPYREEVQ
WDVDTIYLTQ DTRELNMQDF IHLENRDLVA IIAALEYNQW FTKLSTKDYK LSTDICEQIL
RVVSRSSRLE ELLLDNTGLK SDFAQKLAGA LSYNPASTLQ TLNLSNNSLE DKGVSALSAQ
LAKLPMGLKH LNLSRTSMSP KGVNSLCQAL GANASVAATL AHLDLSGNSL RGDDLQNLHS
FLSHPNSLQT LDLSSSDCSL EQVCASLLRG SLKHLSVLNM SKSVFSHRKC REISPSFKQF
FSSAQALSSV SLSGTRLPLE ALKALLLGLG CNPNLSDVSL DLSCCELRSA GSQILEGCVA
EIPNISSLDI SDNSLDMDLT TLLVWLAKNR SIRHLSLGKN FNNIKSKNVS QVLDNLVLMI
QEEDSPLNSL SLADSKLKTD LSIVLNALGS NTSLTKLDIS GNSMGDMGAK MLAKALQINT
KLRTIAWDRN NISPQGLQDV AAALEKNHTI RFMPIPIMDA AQALKASPEK TEEALLKMEQ
YLLRNHETRK YLQDQAYRLQ QGIVTTTTQQ MMDMICVRVQ DHLNSLRFTE TSAVQEDVKA
AENFMKDARN SKKLLPNLHY LKSGGSSGAC VGAIQDKLES MAGEVARVMD EQLQTMLVSM
VDAAEGLCPH VMKRSGLRQE LLKAGAGRMT VPRSFITTTL LEQSGVDIIN KISEVKLSMA
SFLSDRVVDE ILESLSRSQH TL
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