ID G3P6H1_GASAC Unreviewed; 404 AA.
AC G3P6H1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Lipase {ECO:0000256|PIRNR:PIRNR000862};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000013194.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000013194.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000013194.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC {ECO:0000256|ARBA:ARBA00010701, ECO:0000256|PIRNR:PIRNR000862}.
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DR AlphaFoldDB; G3P6H1; -.
DR STRING; 69293.ENSGACP00000013194; -.
DR Ensembl; ENSGACT00000013219.1; ENSGACP00000013194.1; ENSGACG00000009981.1.
DR eggNOG; KOG2624; Eukaryota.
DR GeneTree; ENSGT00940000154696; -.
DR InParanoid; G3P6H1; -.
DR OMA; YACEEHT; -.
DR TreeFam; TF315485; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000009981; Expressed in intestinal epithelial cell and 13 other cell types or tissues.
DR GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR InterPro; IPR025483; Lipase_euk.
DR PANTHER; PTHR11005:SF163; LIPASE; 1.
DR PANTHER; PTHR11005; LYSOSOMAL ACID LIPASE-RELATED; 1.
DR Pfam; PF00561; Abhydrolase_1; 1.
DR PIRSF; PIRSF000862; Steryl_ester_lip; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|PIRNR:PIRNR000862};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963,
KW ECO:0000256|PIRNR:PIRNR000862};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..404
FT /note="Lipase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003449218"
FT DOMAIN 86..385
FT /note="AB hydrolase-1"
FT /evidence="ECO:0000259|Pfam:PF00561"
FT ACT_SITE 180
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR000862-1"
FT ACT_SITE 350
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR000862-1"
FT ACT_SITE 379
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR000862-1"
SQ SEQUENCE 404 AA; 45205 MW; E2810A4C03320DD6 CRC64;
QAMLCLVVCV LSLSALVLSG PTFQRRFDKL HQRLDPEVHM NISEIVRWWG YPAEEHQVPT
EDGYILTVNR IPGGRQHAAG PAGQGPAVFL QHGLLAAGSN WITNLPDSSL GFVLADAGYD
VWIGNSRGNT WSRNHRTLRP NQEEFWRFSY DEMALLDLPA VVNHILKATG QNQISYIGHS
QGTTIAFIAF SSLPELASKI KLFVGLAPVA TVSFTASAMT KLSVLPDFLI WDLFGRRDFL
PQSRMIEWFA EHVCAKQLLS ELCGNLFFVL CGFDEKNLNM TRIPVYTEHC PAGTSVQNMV
HWAQAVHGGK LSAFDFGASG NMKHYNQSTP PEYRVQDMKV PTALFSGGHD TLADPKDIAL
LLTQMSNLVF HQNIEHWDHL DFIWGLDAPT QMFPSILKLL QEYQ
//
