ID G3P6I6_GASAC Unreviewed; 610 AA.
AC G3P6I6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Si:ch211-122h15.4 {ECO:0000313|Ensembl:ENSGACP00000013209.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000013209.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000013209.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000013209.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3P6I6; -.
DR Ensembl; ENSGACT00000013234.1; ENSGACP00000013209.1; ENSGACG00000009991.1.
DR GeneTree; ENSGT00940000157993; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000009991; Expressed in spleen and 9 other cell types or tissues.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04402; RhoGAP_ARHGAP20; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR047886; ARHGAP20-like_RhoGAP.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23179; T-CELL ACTIVATION RHO GTPASE ACTIVATING PROTEIN-RELATED; 1.
DR PANTHER; PTHR23179:SF26; T-CELL ACTIVATION RHO GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635}.
FT DOMAIN 29..215
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 227..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 382..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..274
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 610 AA; 67699 MW; 9FBF954692BE5EA3 CRC64;
LVRRLRKGSS FINKPGRSDT DTKTQLFGQP LCKICTDEHS LPKPVMEVMV QLRKRGPSTE
GVFRRTCHNR NMRDIREQLN SGLEVDLGGQ PVLLLVGLLK SFLKELPGSL LVSDLYDKWM
AALDKEDLQQ RAVEIKRVAD DLPRHNKLLL QHLVCVLHHI LQNAESNKMD AYNLAVCIAP
TLLQLECTPL DEQKEKMKKV TELTQFLIEH CEILGENIPN LLDTDEANHQ SADSLSSQHH
DSAYDSTDPD GDGEAAESSS SRHGESGSYS SLSPSFITSS WPADAIFARR CSEPIIFLSA
DLESLCSHSR SHDDCSVERR DFREQPLKKQ ISDDSFLLKG RDGARADLSF PKLCRKSNMD
PLPYMAGNLS CSSLESAASN QSEGSVFTSS PVGSPACPRK PGNQPSVAAK AQPDIGGPNS
EERKRSQSMR VASRVLMRTR SLGTFSRNSV KKDSQKENSF PCETLQEDSQ SEADAPAELL
HKPRPLSAIE VFKQVDSKLP CRPPSYKQAV QNMGAPPQYG SMTVHDAVQL GRRSRPASLN
YDFPPACSVN QHADCFAEAA QDKAHVDEQR QAFRQRAMSE SVCAGQREVV SRRCSQPVFE
DLSYAKESYV
//
