ID G3PCU6_GASAC Unreviewed; 724 AA.
AC G3PCU6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Transient receptor potential cation channel, subfamily C, member 4b {ECO:0000313|Ensembl:ENSGACP00000015420.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000015420.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000015420.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000015420.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; G3PCU6; -.
DR STRING; 69293.ENSGACP00000015420; -.
DR Ensembl; ENSGACT00000015451.1; ENSGACP00000015420.1; ENSGACG00000011660.1.
DR eggNOG; KOG3609; Eukaryota.
DR GeneTree; ENSGT01060000248594; -.
DR InParanoid; G3PCU6; -.
DR OMA; CIGQVAV; -.
DR TreeFam; TF313147; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR013555; TRP_dom.
DR InterPro; IPR002153; TRPC_channel.
DR NCBIfam; TIGR00870; trp; 1.
DR PANTHER; PTHR10117:SF25; SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 4; 1.
DR PANTHER; PTHR10117; TRANSIENT RECEPTOR POTENTIAL CHANNEL; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF08344; TRP_2; 1.
DR PRINTS; PR01097; TRNSRECEPTRP.
DR SMART; SM00248; ANK; 2.
DR SMART; SM01420; TRP_2; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 298..318
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 330..351
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 413..434
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 454..473
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 494..516
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 543..566
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 578..600
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 109..141
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 144..206
FT /note="Transient receptor ion channel"
FT /evidence="ECO:0000259|SMART:SM01420"
SQ SEQUENCE 724 AA; 83528 MW; 7B3B7FF9D1CA4AB1 CRC64;
LSTLERAYLG AVEKGDYASV KQALEEAEIY FRININCVDP LGRTALLIAI ENENLEIIDL
LLSYNVHVGD ALLHAIRKEV VGAVELLLNH KKPRGEKQVN FPTAVNFTPD ITPIILAAHT
NNYQIIKLLL QRGVSIPQPH AVRCNCVECI SGSDVDGLRH SRSRLNIYKA LASSSLIALS
SEDPFLTAFQ LSWELKELST VENEFKSEYE ELSRMCKQFA KDLLDQTRSS KELETILNYR
DDINPLLDEI TNDLARLKLA IKYCQKEFVA QPNCQQLLAS QWYDEFPGWR RRHWAGKLLT
CIFIGLLFPL FSIFYIISPK SRYGLFIRKP FIKFICHTAS YLTFLLLLLL ASQHIATEQN
DFQGPAPTTV EWLILPWVLG RFVWTEIKQM WDSGLEDYID DWWNLMDFIM NSLYLATIAL
KIVAYAKVSC ILQFRGPKSR KSWEMWHPTL VAEALFAIAN IFSSLRLICL FTANSHLGPL
QISLGRMLLD ILKFLFIYCL VLLAFANGLN QLYFYYDTNE GSNCKGIRCK DQNNAFSTCM
ACWFFRLFET LQSLFWSVFG LISLYVTNVE PRHEFTEFVG STMFGTYNVI SLVVLLNMLI
AMMNNSYQHI ADHADIEWKF ARTKLWMSYF EEGGTLPSPF NIIPSPKSIY YSFGWIYSRL
FKRSSLKRLE TFETLGEVLK HLMKRYVAAM IRDAKTEEGL TEENFKELKQ DISSFRYEVL
GMMK
//
