ID   G3PDM6_GASAC            Unreviewed;       437 AA.
AC   G3PDM6;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   SubName: Full=2-epi-5-epi-valiolone synthase {ECO:0000313|Ensembl:ENSGACP00000015700.1};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000015700.1, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000015700.1, ECO:0000313|Proteomes:UP000007635}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000015700.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC         Evidence={ECO:0000256|ARBA:ARBA00001911};
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DR   AlphaFoldDB; G3PDM6; -.
DR   STRING; 69293.ENSGACP00000015700; -.
DR   Ensembl; ENSGACT00000015731.1; ENSGACP00000015700.1; ENSGACG00000011871.1.
DR   eggNOG; KOG0692; Eukaryota.
DR   GeneTree; ENSGT00390000011238; -.
DR   InParanoid; G3PDM6; -.
DR   OMA; TGINTPY; -.
DR   TreeFam; TF333049; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   Bgee; ENSGACG00000011871; Expressed in embryo and 1 other cell type or tissue.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:InterPro.
DR   CDD; cd08199; EEVS; 1.
DR   Gene3D; 3.40.50.1970; -; 1.
DR   Gene3D; 1.20.1090.10; Dehydroquinate synthase-like - alpha domain; 1.
DR   InterPro; IPR030960; DHQS/DOIS.
DR   InterPro; IPR035872; EEVS-like.
DR   PANTHER; PTHR43622; 3-DEHYDROQUINATE SYNTHASE; 1.
DR   PANTHER; PTHR43622:SF1; 3-DEHYDROQUINATE SYNTHASE DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF01761; DHQ_synthase; 1.
DR   SUPFAM; SSF56796; Dehydroquinate synthase-like; 1.
PE   4: Predicted;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239}; NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635}.
FT   DOMAIN          116..379
FT                   /note="3-dehydroquinate synthase"
FT                   /evidence="ECO:0000259|Pfam:PF01761"
SQ   SEQUENCE   437 AA;  48645 MW;  F11EAD14131FAF26 CRC64;
     MGTWKCKLGH KVNKDTADCV SAAKIYESIT EQGASWTVVS PIVFTYKVTE TRHLLDPSND
     TLLLGHITDP QQLDDIQKSN KPIKRFLVVD QEVYRIYGTK ITAYLEANNV LYKILSLPTT
     EENKSMQMAL KILEEINNFS LDRRTEPIIA IGGGVCLDIV GLAASLYRRR TPYIRVPTTL
     LSYIDASVGA KTGVNFANCK NKLGAYIPPA AAFLDLSFMQ TVPRRHISNG LAEMLKMALM
     KHRGLFELLE THGRMLLDTK FQADNSVYGN HCLQAASQAT RIAIVTMLEE LAPNLWEDDL
     DRLVDFGHLI SPALEMNVLP SLLHGEAVNV DMSYMVYVSR ERGLLTEDEK QRIISCMLGL
     ELPVWHAAFT MELIQKSLQD RLKHSGGLVR MPLPVGLGKA EISNDTPYNK AKAMLLTMCE
     GCRGLQWAAV CGGCRGL
//