ID G3PEG6_GASAC Unreviewed; 864 AA.
AC G3PEG6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Glutamate receptor, metabotropic 6b {ECO:0000313|Ensembl:ENSGACP00000015990.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000015990.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000015990.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000015990.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
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DR AlphaFoldDB; G3PEG6; -.
DR STRING; 69293.ENSGACP00000015990; -.
DR Ensembl; ENSGACT00000016021.1; ENSGACP00000015990.1; ENSGACG00000012070.1.
DR eggNOG; KOG1056; Eukaryota.
DR GeneTree; ENSGT01030000234648; -.
DR InParanoid; G3PEG6; -.
DR OMA; EACPRDM; -.
DR TreeFam; TF313240; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000012070; Expressed in camera-type eye.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15286; 7tmC_mGluR_group3; 1.
DR CDD; cd06376; PBP1_mGluR_groupIII; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR001786; GPCR_3_mGluR4.
DR InterPro; IPR000162; GPCR_3_mtglu_rcpt.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24060:SF170; GLUTAMATE RECEPTOR, METABOTROPIC 6B; 1.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01054; MTABOTROPC4R.
DR PRINTS; PR00593; MTABOTROPICR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00979; G_PROTEIN_RECEP_F3_1; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 565..591
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 603..623
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 677..698
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 729..750
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 762..784
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 565..839
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 864 AA; 96146 MW; 95EF6A1E750877A4 CRC64;
LLVSTGPGSW AQQGSQPQSI KIEGDITLGG LFPMHSRGAA GVPCGEIKRE KGIHRLEAML
YAMDQINSDP DLLPNITLGA RILDTCSRDT YALEQSLLFV QALIQKDTSD VRCSNGEPPI
IPKPERVVGV IGASGSSVSI MVANVLRLFS IPQISYASTA PELSDKSRYE FFSRVVPPDS
YQAQAMVDIV KAMGWNYVST LASEGNYGES GVDAFLQISR EAGGLCIAQS IKIPREPRPN
EFEKIIKRLM ETSNARGVII FANEDDIKRV LQSAKKANLT GHFLFVGSDS WGAKSSPIQD
QEDVAEGAVT ILPKRASIDG FDQYFTSRSL ENNRRNIWFA EFWEDDFKCK LTRPGIKYEL
GRRKCTGEER IGHHSQYEQE GKVQFVIDAV YAMAHALHSM HLDLCPGYMG VCEKMDPVEG
QMLLQYIRAV SFNGSAGTGV MFNENGDAPG RYDIFQYQLS NVSSPGYKVI GQWTNHLRLN
ADEMQWSGGH RRIPDSVCSF PCESGERKKM VKGVPCCWHC ELCDGYQYLL DEFTCDMCPF
DMRPLKNRTG CRPTPIIKLE WSSPWAIIPV FLAILGILAT TGVIVTFIRF NDTPIVRASG
RELSYVLLTG IFLIYLITFL MIAEPSTAVC AFRRLLLGLG MCISYSAMLT KTNRIYRIFE
QGKKSVTPPK FISPTSQLII TFILISVQLL GVFIWFGVMP PHTIIDYEEQ KPPNPEFARG
VLKCDMSDLS LILCLSYAIV LMITCTVYAI KSRGVPETFN EAKPIGFTMY TTCIVWLAFV
PIFFGTAQST EKMFIQTTTL TVSMSLSATV SLGMLYIPKA YVIICHPEQN VQKRKRSFKA
VVQAATVSTH LSQKSNDKTN GESK
//
