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Database: UniProt
Entry: G3PEK3_GASAC
LinkDB: G3PEK3_GASAC
Original site: G3PEK3_GASAC 
ID   G3PEK3_GASAC            Unreviewed;      1908 AA.
AC   G3PEK3;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   20-DEC-2017, entry version 42.
DE   RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000016027};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000016027}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000016027}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1C
CC       gives rise to L-type calcium currents. Long-lasting (L-type)
CC       calcium channels belong to the 'high-voltage activated' (HVA)
CC       group. They are blocked by dihydropyridines (DHP),
CC       phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA
CC       (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-
CC       GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing the alpha-1C subunit play an important
CC       role in excitation-contraction coupling in the heart. Binding of
CC       calmodulin or CABP1 at the same regulatory sites results in an
CC       opposit effects on the channel function.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSGACP00000016027}.
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DR   STRING; 69293.ENSGACP00000016027; -.
DR   Ensembl; ENSGACT00000016058; ENSGACP00000016027; ENSGACG00000012097.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   InParanoid; G3PEK3; -.
DR   OMA; LALVEWK; -.
DR   TreeFam; TF312805; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0050808; P:synapse organization; IEA:Ensembl.
DR   InterPro; IPR031688; CAC1F_C.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005446; VDCC_L_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16885; CAC1F_C; 2.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01630; LVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007635};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     55     74       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     94    113       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    125    142       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    200    223       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    279    300       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    312    334       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    464    481       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    501    523       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    588    608       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    669    693       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    806    824       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    836    859       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    879    902       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    923    956       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1047   1074       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1126   1146       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1158   1177       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1262   1280       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1354   1377       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1511   1545       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      734    754       {ECO:0000256|SAM:Coils}.
FT   COILED     1626   1646       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1908 AA;  214110 MW;  3FE8ED44B7495749 CRC64;
     SDTLGSGGSA RKRGGGAKKA MQANKSALRA PRALCCLTLS NPIRMAALAL VEWKPFDIFI
     LLAIFANCVA MGVTKPYPDD DSNATNHQLE QVEYVFLVIF TIETFTKILA YGLVMHPSAY
     IRSGWNLLDF VIVIVGLFSV MAEGMTDHKP GEAHHAAGKP GGLDVKALRA FRVLRPLRLV
     SGVPSLQIVL NSIMKAMVPL LHIGMLVMFV IIIYAIIGLE LFIGRMHKTC YSSTTGLMIE
     DDPSPCAFAG SGRFCVGNGT ECRGKWEGPN GGITNFDNVF FAMLTVFQCI TMEGWTDVLY
     WMNDAIGFEI PWVYFVSLVI FGSFFIINLV LGVLSGEFSK EREKAVARGE LQQAQESKQM
     EEDMIGYMDW LIEAEDVDEE GNKHNPPPPP QKKNYTRLYI SLQHPTSISP QRCCHREEED
     DEEGTSAACR RVGAKMMANS FCDQLCQLNH TLRKNCRVAA KTNNFYWLVL LLVFLNTVAS
     ASEHYGQPNW LTEMQERANK ILLLLFTLEM LMKMYAFGLQ IYFMALFNRF DCFVVCGGIL
     ETLLVELQFI PPIGISVLRC IRLLRIFKMT RRHWAALSDL VNSLLNSMKA ICSLLLLLFL
     FLIIFALLGM QLFGGKFNFD ETQMKRSTFD SFPQALLTCF QILTGEDWNA VMYDGIMAYG
     GPIFPNMVVC IYFVILFVCG NYILLNVFLA IAVDNLAGGG GKTVVEKREM MISDHSSISP
     DLHTEHRTIQ ESSLREKKED EDEWDEDNEK EDEDAAYFVA GVAPLKPEFS GPKEKIVPIP
     DGSSFFILGK KNCLRVACHN LIHHPYFTNF ILVFIILSSI SLAAEDPIKS HSFRNIVLGY
     ADYVFTSVFT VEIVLKMTVY GAFLHSGSFC RNAFNLLDLV VVGVSLMSFF LHSSAISVVK
     ILRVLRVLRP LRAINRAKGL KNVVQCVFVA IRTIGNILIV TTLLQFMFAC IGVQLFKGRF
     YSCTDEAKHD PVECRGTFVV YKDGDMNHPM VRERIWENSD FNFDNVLQGM LALFTVSTFE
     GWPQLLYRSV DANAINRGPI YNYRVEISIF FIIYIIIIAF FMMNIFVGFV IITFREQGEA
     EFKNCELNKN QRQCVYYALK AQPIKIYIPK DPSQLKFWRI INSSQFEYIM FVLILGNTLT
     LAVQHYEQSK GFTSIMDILN MIFTVVFTIE MIIKLLALRV HHYFIDPWNS FDALIVVGSV
     LDIAVSELSG GGGHGEGPGK GESGKVSITF FRLFRVLRLV KLLSKGEGIR TLLWTFVKSL
     QALPYVGLLI AMIFFIYAVI GMQTFGKVAI DDDTHINRNC NFQTFFMAVL VLFRCATGEQ
     WQEIMLAALP GRRCDPEADT EPGEEFNCGS NLSYIYFISF FMLCAYLIIN LFIAVIMDNF
     EYLTRDWTVL GTHHLDEFKR VWSDYDPEAT GRIKHIDVVT MLRRIQPPLG FGKLCPHRVA
     CKRLVAMNVP LHSDGTVTFS ATLFALVRTS LKIKTEGPID KQNEELKLII KKLWKHTRPK
     LIDEVIPPPR GEEVTCGKFY ASFLIQDYFK KYRKRKERER KSKRKDRAAS LQLGLRTLQD
     LAPEMRLAMA CDLEEEEGAE GEVTGDDLFD SGPGTSASVP LAGNSLSPIN KLVEQITVLM
     ENEFKKAEEE EEVVVVTEQV AGLQEHQRPW SELAGVRVVT EQPLRSEALP LREEPIDEEI
     APDVVEEPAA VAATAEEQVC CIEEDAAGGA PVDGRRLLPL IPQGQKPSFN LQCLRPQSSV
     DNLPIPGTFR GAAPPLRSHI HGTMPASGRR GKLVYTPMIL VDEATGNSQP LWSDGSASLP
     VGARAPGWYP GQTRTFTSMR MPPVGQGFVD KGSADSLVES ILISEGLGVY ARDPKFVSFA
     KREIAEACHM SLDDMESAAT DLIARGASQS MARFEDELAD EMNCVISY
//
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