ID G3PFU6_GASAC Unreviewed; 2459 AA.
AC G3PFU6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Notch receptor 2 {ECO:0000313|Ensembl:ENSGACP00000016470.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000016470.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000016470.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000016470.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NOTCH family.
CC {ECO:0000256|ARBA:ARBA00005847}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 69293.ENSGACP00000016470; -.
DR Ensembl; ENSGACT00000016502.1; ENSGACP00000016470.1; ENSGACG00000012442.1.
DR eggNOG; KOG1217; Eukaryota.
DR GeneTree; ENSGT00940000155030; -.
DR InParanoid; G3PFU6; -.
DR OMA; AHMSEPP; -.
DR TreeFam; TF351641; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000012442; Expressed in spleen and 9 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043235; C:receptor complex; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:InterPro.
DR GO; GO:0060351; P:cartilage development involved in endochondral bone morphogenesis; IEA:Ensembl.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0071228; P:cellular response to tumor cell; IEA:InterPro.
DR GO; GO:0031018; P:endocrine pancreas development; IEA:Ensembl.
DR GO; GO:0060325; P:face morphogenesis; IEA:Ensembl.
DR GO; GO:0042593; P:glucose homeostasis; IEA:Ensembl.
DR GO; GO:0001889; P:liver development; IEA:Ensembl.
DR GO; GO:0001946; P:lymphangiogenesis; IEA:Ensembl.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:1990798; P:pancreas regeneration; IEA:Ensembl.
DR GO; GO:0050793; P:regulation of developmental process; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0042246; P:tissue regeneration; IEA:Ensembl.
DR CDD; cd00054; EGF_CA; 25.
DR CDD; cd21703; JMTM_Notch2; 1.
DR Gene3D; 3.30.300.320; -; 1.
DR Gene3D; 3.30.70.3310; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.10.25.10; Laminin; 35.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR008297; Notch.
DR InterPro; IPR035993; Notch-like_dom_sf.
DR InterPro; IPR022336; Notch_2.
DR InterPro; IPR024600; Notch_C.
DR InterPro; IPR000800; Notch_dom.
DR InterPro; IPR010660; Notch_NOD_dom.
DR InterPro; IPR011656; Notch_NODP_dom.
DR PANTHER; PTHR24044; NOTCH LIGAND FAMILY MEMBER; 1.
DR PANTHER; PTHR24044:SF411; SUSHI, NIDOGEN AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF00008; EGF; 22.
DR Pfam; PF07645; EGF_CA; 3.
DR Pfam; PF12661; hEGF; 5.
DR Pfam; PF06816; NOD; 1.
DR Pfam; PF07684; NODP; 1.
DR Pfam; PF00066; Notch; 3.
DR PIRSF; PIRSF002279; Notch; 1.
DR PRINTS; PR00010; EGFBLOOD.
DR PRINTS; PR01452; LNOTCHREPEAT.
DR PRINTS; PR01983; NOTCH.
DR PRINTS; PR01985; NOTCH2.
DR SMART; SM00248; ANK; 6.
DR SMART; SM01334; DUF3454; 1.
DR SMART; SM00181; EGF; 35.
DR SMART; SM00179; EGF_CA; 34.
DR SMART; SM00004; NL; 3.
DR SMART; SM01338; NOD; 1.
DR SMART; SM01339; NODP; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 24.
DR SUPFAM; SSF57184; Growth factor receptor domain; 4.
DR SUPFAM; SSF90193; Notch domain; 3.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 22.
DR PROSITE; PS00022; EGF_1; 34.
DR PROSITE; PS01186; EGF_2; 28.
DR PROSITE; PS50026; EGF_3; 35.
DR PROSITE; PS01187; EGF_CA; 9.
DR PROSITE; PS50258; LNR; 3.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023};
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR002279-1};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR002279-2};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR002279-1};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 12..55
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 58..96
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 97..134
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 136..174
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 176..213
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 215..251
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 253..291
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 293..329
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 330..368
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 370..408
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 410..446
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 448..484
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 486..522
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 524..559
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 561..597
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 599..634
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 636..672
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 674..709
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 711..747
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 749..785
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 787..823
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 830..866
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 868..904
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 906..942
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 944..980
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 982..1018
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1021..1057
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1070..1105
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1107..1143
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1145..1181
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1183..1225
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1227..1265
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1267..1306
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1309..1345
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1346..1384
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1396..1436
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT DOMAIN 1437..1473
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT DOMAIN 1475..1516
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT REPEAT 1845..1877
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1912..1944
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1945..1977
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1978..2010
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 1805..1826
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2066..2207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2263..2297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2323..2459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2093..2107
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2147..2187
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2272..2293
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2356..2377
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2398..2459
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 390
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 393
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 410
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 411
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 413
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 427
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 451
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 465
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT DISULFID 45..54
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 86..95
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 124..133
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 164..173
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 203..212
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 241..250
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 281..290
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 319..328
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 339..356
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 358..367
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 374..387
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 381..396
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 398..407
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 414..425
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 419..434
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 436..445
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 452..463
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 457..472
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 474..483
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 512..521
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 528..538
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 549..558
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 587..596
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 603..613
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 624..633
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 662..671
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 678..688
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 699..708
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 737..746
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 775..784
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 796..813
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 856..865
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 894..903
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 932..941
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 970..979
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1008..1017
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1047..1056
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1095..1104
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1133..1142
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1171..1180
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1215..1224
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1236..1253
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1255..1264
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1296..1305
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1335..1344
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1350..1360
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1374..1383
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2459 AA; 263661 MW; 7DF8752DC0E0B350 CRC64;
CAPGFLGEYC HHKDPCHPGF CLNGGDCSVS MSAGVPVPGS AACTCPLGYT GQHCQTPQNS
TCYPNNPCAN KGVCALLSLD KYKCKCPRGW TGPQCEHEDS CLSSPCANGG KCSSPSAGSY
TCSCPPGYEG PRCLNDTNEC AASPSICQNE GRCVNTPGSY KCTCDPGFTG RHCESSYIPC
SPSPCLNGGT CHQNTETSYS CHCLPGFNGT NCENNIDDCP GHQCANGGTC MDGVNTYNCQ
CPPEWTGQHC TEDVDECRLQ PNTCQNGGTC SNLFGSYVCV CVNGWSGLHC SENIDDCATA
ACSPGSTCID RVASFVCLCP YGKTGLLCHR DDACISNPCR EGSQCDTNPI SGMFNCNCAP
GYVGSTCNID RDECSIGTNP CEHGGQCVNT DGSFTCNCVR GYAGPRCEQD VNECASNPCQ
NEGTCLDRIG DYTCICMPGF EGTHCEVEIN ECISSPCLNQ GKCLDQVSRF VCECPAGFSG
EMCQIDIDEC SSTPCLNGAK CIDRPNGYDC ECAEGFTGLL CGDNINDCVP EPCHHGSCKD
GIATFSCECD PGYTGSICNI QVQECHSNPC QNRAHCVDLV NGYQCNCPTG TRGVNCEINE
DDCDSNPCEY GECQDGIDEY KCVCAPGYTG LKCNVDINEC SSNPCMSGGT CIDKVNGFHC
LCPPSTHGPL CLSGTDHCAP QPCVHGECIE QQHGYRCECE AGWVGQHCEQ EKDECRPNPC
QNGGACVDRH NGYTCQCQPG FRGVSCEKNI DECASGPCLN HGLCLDGVSS YSCQCSPPFT
GKHCEVEQVP CASHPCERGG VCRPSPDYTS YTCRCPAGWQ NCAGPRCSED VDECKKNPCR
NGGRCVNNQG SYTCRCQPGY SGHNCQTDID DCSPSPCQNG GSCVDDVGSF SCDCRQGFEG
ERCEMEVDEC ASQPCRNGAV CRDYVNSFVC ECRPGFDGIL CERDILECTE SSCLNNGTCI
DEVNAFSCRC RPGFYGTFCE YEQNECDSQP CKNGGTCTDG LGSYRCTCSM GYNGQNCQQN
FVNLCSQVRC LNGGSCSQTS TSWTCHCQMG WTGLYCDVPN MSCQDYAARN GREVENVCEN
AGRCINVGHS HRCQCQPGYT GSYCKEMVDE CQSNPCRNGA TCKDYQGTYE CICKPGYQGV
NCEYDVDECH SRPCLHGGTC INLINRFTCA CPPGAHGLQC EVNEDECAAK AGSFEPRCLN
GGQCVDGVGR YSCSCPPGFV GEHCEGDLNE CLSGPCHAPG SLDCVQLVND YQCRCRLGYT
GRHCESMVDL CLSKPCHKGG VCSMNMSSVH GYTCSCVPGF TGFNCGEIEG YSCAKLRCQN
GGRCVESTGR LSCQCQPGFS GPHCENEHRC PWNCQNGGTC VKDPSNPYQY SCRCAAHFSG
PYCESGQQIV PRTPTCRYPQ CEQHSRDKVC DAQCNNHECQ WDGGDCSLNW QQPWVNCTAS
VPCWDLFKNG LCNKECDNPG CLFDSFECQE TPASCKYVTY DRYCADHFGN GDCDPSCYTE
ACGWDGLDCS IDTPAKVIDG TLVIVVRLQP KELLGDLRGF LRSLGALLHT NLQVKLDQNN
KPMVYPFYGE EHGLHIQRRR SKRELEKEVI GSVVHLELDN RECSQSSVDC FSNTDEAASF
LAAAHIKAEL PYPLVSVKSE PSVNPPPPRA LMYLVGLAVV ITLLILVLGM LAAKRKHKHG
ALWLPDGFLA NKNDKRREPV GQDDFDMKNF KTQDGALIDG VQSQRWLKDE VPSKKQRTED
KPLLPIAMEG SVDRREWTLQ HRKAADISLT PPQADLDADC LDVNVKGPDG FTPLMLASLR
NGGGPDCSLH AAEEEEESGG DEPGPSVISD LIAQGASLMA QTDRTGETAL HLAARYARAD
AAKRLLDAGA DPNGHDNMGR TPLHAAVAAD AQGVFQILIR NRATELDARM NDGTTPLVLA
ARLAEEGMVE ELIHCHADIN AVDDHGKSAL HWAAAVNNVQ ATLVLLKNGA NRDMQDNKEE
TPLFLAAREG SFEAAQVLLD HYSNRDITDH LDRLPRDTAQ ERMHHDIVRL LDQYNLVHSP
HGPNHMGGGG NSSVMCGANG VGFIGMRPGP QGKKSRRGGG GAKVGGAGGG AKELKDMKAK
RRKKPPGGEG PVVGAGGAGG GGGGAAGTGG GNANGAKAAA GLPESSVTMS PVDSLESPHS
YTGDVSGAAA TTANSPPLMS SPTSRPMLPP VSHMLGQQPG WGGMTKHGYG GHMFGHVSHQ
MGGSHPGMSQ HHVQGPMLST MNVTMSREQL PPIVTFQMMA PGGGQAMLKP PQPGQVQVTQ
SQGQSQNQGH AQQGAGHLRC PQGMMYRMSE QMSMAHGLPH ALQHPHAVSH GGHAGIEAQS
RPLPSYPPMQ SPVDKYPTPP SQHSYTTTGS EGTTPGHSAH PPSEHPYLTP SPESPDPWSS
SSPHSNSDWS DVTTSPTPLG NTTHCRLRTT HTFQSRRSSS RRPSRCSRPL SRLSTATCR
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