ID G3PHA1_GASAC Unreviewed; 956 AA.
AC G3PHA1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=MAM domain containing glycosylphosphatidylinositol anchor 2 {ECO:0000313|Ensembl:ENSGACP00000016976.1};
GN Name=MDGA2 {ECO:0000313|Ensembl:ENSGACP00000016976.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000016976.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000016976.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000016976.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3PHA1; -.
DR STRING; 69293.ENSGACP00000016976; -.
DR Ensembl; ENSGACT00000017010.1; ENSGACP00000016976.1; ENSGACG00000012846.1.
DR eggNOG; ENOG502QSMD; Eukaryota.
DR GeneTree; ENSGT00940000155369; -.
DR InParanoid; G3PHA1; -.
DR OMA; AYSLEWT; -.
DR TreeFam; TF330345; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000012846; Expressed in telencephalon and 2 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 1.
DR CDD; cd00096; Ig; 2.
DR CDD; cd06263; MAM; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 7.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000998; MAM_dom.
DR PANTHER; PTHR45080; CONTACTIN 5; 1.
DR PANTHER; PTHR45080:SF33; MUSCLE ASSOCIATED RECEPTOR TYROSINE KINASE; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13927; Ig_3; 3.
DR Pfam; PF00629; MAM; 1.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 5.
DR SMART; SM00137; MAM; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50835; IG_LIKE; 5.
DR PROSITE; PS50060; MAM_2; 1.
PE 4: Predicted;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022989};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 25..125
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 132..217
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 240..325
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 338..434
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 538..626
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 636..736
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 743..921
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT REGION 772..791
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 772..788
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 956 AA; 106854 MW; B92191CEBE4D3412 CRC64;
LLFGAVSLVS VCMKTKCALI SAAPPSVRIV HSGHACNVEE ERHAERVYTI REGETLELTC
LVTGHPRPQI RWTKTAGSVS DRFQDSSVFN ETLHIAKILR TQGGRYYCKA ENGLGSPAIK
SIRVDVYYLE DPVVTVHQSI GEAKEQFYYE RTVFLRCVAN SNPPVRYSWH RGREVLTQGS
DKGVEIYEPF FTQGETKILK LKNLRPQDYA NYSCVASVRN VCGIPDRSVI FRLTNKTASP
SIKLLVEDPI VVNPGQTVSL VCITTGGEPP PLLTWISSND SLPQRSVVKG GTLTLPAITS
DEAGVYSCVA SNNVGNPAKK STTIVVRALK KGRFWITPDP YHNDDNIQIG REVKISCQVE
ATPPEELTFG WLKNGRALRS SERMVITQTD PDISPGTTNL DIIDLKFTDF GTYTCVAALK
GGGIPEISID VNISSTTAMQ PRLLWPGGKS PLVGREGDTV ELEWPVSREP QAIILWSPGD
QEAPMPDARM QISYHGVLVS VMVSPEMTAS YRCQTNQYNG FTTSLPEKRI LRIISDPPTV
EPVNTEMRQG LGRPVVMTCR VLRAHPSRVL RFEWLLSNRL LHAGAFDAQR DETEYTIRSL
NRDGWGEYTC NVINEAGAGK CTFQVTGKGY ASEFYYDTLP LWQNRPRSTG FQLQWTQMPN
MVDRIVAYRL GIRQMGLQRW WEQEIPVDGA INKGELMTHN LTELMKPESY EVRLTPITRF
GEGDSTIRII TYSAPVNPHL REFHCSFEEE TICMFTQDKN DDFDWTRHSA STRDTKYTPN
TGPSGDRTDS KQGFYMYIET SRPRKDGDQA RLISPFFNVA PKNPYGINNP PAYCFGFFYH
MYGKHIETGT LNAHLKQKGQ TASEAPVWSL NGNQNDRWKQ AKVSIRPTAS FQVVLEGIRG
PGIEGDIAID DVTLEEGECR DPPPSAVDLS AKAPSTSSHI WLLCVTLVMT LLQGQR
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