ID G3PJ24_GASAC Unreviewed; 706 AA.
AC G3PJ24;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 08-NOV-2023, entry version 70.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS50026};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000017603.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000017603.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000017603.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; G3PJ24; -.
DR STRING; 69293.ENSGACP00000017603; -.
DR Ensembl; ENSGACT00000017637.1; ENSGACP00000017603.1; ENSGACG00000013316.1.
DR eggNOG; KOG1215; Eukaryota.
DR GeneTree; ENSGT00940000162544; -.
DR InParanoid; G3PJ24; -.
DR OMA; GVHHPYD; -.
DR TreeFam; TF351700; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000013316; Expressed in mesonephros.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00112; LDLa; 7.
DR Gene3D; 4.10.1220.10; EGF-type module; 2.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 5.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR PANTHER; PTHR22722:SF12; SI:DKEY-88L16.3; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF00057; Ldl_recept_a; 7.
DR Pfam; PF00058; Ldl_recept_b; 1.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00192; LDLa; 7.
DR SMART; SM00135; LY; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 7.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01209; LDLRA_1; 3.
DR PROSITE; PS50068; LDLRA_2; 7.
DR PROSITE; PS51120; LDLRB; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..706
FT /note="EGF-like domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003449839"
FT DOMAIN 353..390
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 530..573
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DISULFID 47..62
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 86..101
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 125..140
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 166..181
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 211..226
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 231..243
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 238..256
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 250..265
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 285..303
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 706 AA; 77343 MW; 7C6F0F97DD33484C CRC64;
MGGCMRLCAV LLLWSGLLQV HSISLKCGRG SRMCKDGSDC IPYNELCDGE LDCKDGSDEE
DCASECIKDQ FQCAHGKKCI DEDQVCDGVP QCQDRSDEMH CKKQSESCVH HCDQNRRCVP
ATFLCDGEKD CLDGSDETNC GTPIKCQLGS RPCQNKFQCV PYNHFCDGEA DCKDGSDEEE
CALSCETGNL MTGCDHQCDD NLHCIPKSFL CDGERDCVDL SDEANCAEMG CSPTEFQCVS
GQCMSATMFC DGHPDCQDHS DEDDCATAPV CTTKHSCPQS KQFQCGSQDC VDQIHVCNHN
ADCADGSDEG VSCEIKCAAD SRCSQGCYNT PRGPHCRCAA GFRLMEDGLT CADIDECEDR
WPSMCSQLCI NTQGSYKCDC HPGYIMETAG RHCKITGEPL LLLSIQTNLF LFGLRSGSLD
MLPSSSAEKA ILSLDYDWRD QKVFWVSLDT DGIRWSSLDQ KSTGTVIKGV RADSIAVDWL
GRNMYWIDGV NSQIVAIRLR KGTVKSVDHS IILDEDLDQP RSLALLPQKG LMFWTEIGNV
AKIERAGMDG SQRIAVVNSS LGWPGGVAVD AISERVYWTD ERLRAIGSAT LAGDDIQVTA
FERGYLMKET NNPFSLAVFN DMLYWADARK RVVLAAHKNS GKNLKVLLKR PGQPFGVKVL
HPFLQMGVEN PCEKISCSHM CVFAPGPKAV CKCPAGLILA EDGLAC
//