ID G3PJM3_GASAC Unreviewed; 912 AA.
AC G3PJM3;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Ras and Rab interactor 2 {ECO:0000313|Ensembl:ENSGACP00000017803.1};
GN Name=RIN2 {ECO:0000313|Ensembl:ENSGACP00000017803.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000017803.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000017803.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000017803.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RIN (Ras interaction/interference) family.
CC {ECO:0000256|ARBA:ARBA00006919}.
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DR AlphaFoldDB; G3PJM3; -.
DR STRING; 69293.ENSGACP00000017803; -.
DR Ensembl; ENSGACT00000017838.1; ENSGACP00000017803.1; ENSGACG00000013466.1.
DR eggNOG; KOG2320; Eukaryota.
DR GeneTree; ENSGT00940000154866; -.
DR InParanoid; G3PJM3; -.
DR OMA; MAFCCIS; -.
DR TreeFam; TF331067; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000013466; Expressed in intestinal epithelial cell and 9 other cell types or tissues.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:1903670; P:regulation of sprouting angiogenesis; IEA:Ensembl.
DR GO; GO:0030947; P:regulation of vascular endothelial growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.20.1050.80; VPS9 domain; 1.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR003123; VPS9.
DR InterPro; IPR045046; Vps9-like.
DR InterPro; IPR037191; VPS9_dom_sf.
DR PANTHER; PTHR23101; RAB GDP/GTP EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23101:SF51; RAS AND RAB INTERACTOR 2; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF02204; VPS9; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00167; VPS9; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF109993; VPS9 domain; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS51205; VPS9; 1.
PE 3: Inferred from homology;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT DOMAIN 103..196
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 630..770
FT /note="VPS9"
FT /evidence="ECO:0000259|PROSITE:PS51205"
FT DOMAIN 800..891
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT REGION 224..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 286..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 335..440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 287..306
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 307..321
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 349..379
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 387..408
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..440
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 912 AA; 100943 MW; 6494A5DF3C089E53 CRC64;
MSTSTMTQPP RQERKGSFFK LIDSFACEIV TLKKEMGKKK VAEEDHVTDP LLGLGEEVGG
LFYQASPCTG IRAGLVGARD SGYDSLRRRL SVLDRLVQTH GVWLQLGLSH QDATRVLQSR
PDGTFLVRKS TSLQKKVISV RMNKDSAVPV KDFPVKESQY SFSLVGSGLS FADLFRLVAF
CCISRDVLPF TLKLPEAISS ATTSADLEEV AKLGAGFWDA PAGHRRTESL SSSGISAPER
PPPPVCLTNS PRRPRLRTRT PSELESCQSN GALCFINPLF IKVHQPEGDH SSTTATAKIS
ATDSGQRSPP PRPPPPRLAA PLQQHSMPEK ISWINVPKEK DSPISIPRPS LPISLSSLSS
SPRRLNASPS SSQEDAQCHL ALEEQTIERA ESSSPSDSAT MTTSKQADGT GGHKEEGGEE
CSGGSQRLSD MSLSTDSSDS LDFSQCSAFF LTEDDEDDEE EPDYGVSLES DQDQDLTMVP
PGHRMKRRPS AGALILQRAL RGHLRKMSGV FNSLLTPEKR AVRRVLELSR DKGSYFGCLV
QDYLSYMGEG AGTQAWQGYA SGLELLQTLR QFITQMKSYL RQSSELEPPI ESLIPEDQID
GVLEKAMHKC VLKTLKPVVS AALQEFQVRS GEWRQLKENL SLAKARQPQE MGVADTPPPD
PTAIEKIKHK FHTMSKLYSP EKKVTMLLRV CKLIYTIMED NSGRLYGADD FLPMLTYVLA
QCDMPQLDNE ILYMMELLDP SMLHGEGGYY LTSAYGAMSL IRNFQEEQAA RVLSSETRDT
LHQWHRRRTT QRSAPSIDDF QNYLRVALQE LDSGCTAKTL QVRPYASVEE VCRLCAQKLK
VADPENYGLF LLMEGSSQQL AADTHPQKIK AELHSRSQST PFHFVFRRVA DSKASSSAPP
ELMANLNDLT MT
//
