ID G3PJY0_GASAC Unreviewed; 1247 AA.
AC G3PJY0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Adhesion G protein-coupled receptor G6 {ECO:0000313|Ensembl:ENSGACP00000017910.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000017910.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000017910.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000017910.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR AlphaFoldDB; G3PJY0; -.
DR STRING; 69293.ENSGACP00000017910; -.
DR Ensembl; ENSGACT00000017945.1; ENSGACP00000017910.1; ENSGACG00000013550.1.
DR eggNOG; KOG3714; Eukaryota.
DR eggNOG; KOG4193; Eukaryota.
DR GeneTree; ENSGT00940000155621; -.
DR InParanoid; G3PJY0; -.
DR OMA; AVHHPIC; -.
DR TreeFam; TF321769; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000013550; Expressed in testis and 1 other cell type or tissue.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd00041; CUB; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR001759; Pentraxin-related.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF290; ADHESION G-PROTEIN COUPLED RECEPTOR G6; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF00354; Pentaxin; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00159; PTX; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS51828; PTX_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00059};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 848..871
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 883..902
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 908..932
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 952..975
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1011..1033
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1054..1072
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1078..1101
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 9..117
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 846..1102
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 321..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 380..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 440..464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1123..1155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 340..359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 380..421
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 445..461
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1124..1155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 62..79
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
SQ SEQUENCE 1247 AA; 135460 MW; 9BFD95FBA3E1A075 CRC64;
ALGCSSSSCN VELTEAQGEF TSPCYPQKYP NLQACKWTMQ APAGFIVQLS FLDFDLEEAP
GCIYDRVLVH AGNADVRFCG PTASGLTLNS TGDVMELSFT SDFSVQKRGF SVSFPTRINR
TQGAWRSFPE LHWGHPVIDG SIGSPVPTVS QPTLCFEVHA SNPHTGEWIL SYSDSSGSEA
LSLGSDQSSM KVLVDGVVCP VDSILSPADF TSSMRRYCLL WTASDGRVGV HFNGNYWATT
CSASTGRSLP PAGRFRLGES AHSFLASGQQ SFDGNVYNLR LWDYAMTVQQ LNALSCDAVG
NVIDWDNSHW SIPSGSAQTD TSLSCSESVL PPIPASPSTA PTTSMPLTPT SSSSSSLPSA
STVSLPCVTV YVPVAQQTAV SSAPTNPPTT NPAAPGSTGT LSSETSGLPP QTETPTQFQD
PPRLHLHTFD LAETGLCGLS SGNITKNRRR REPKEQSSVM THAREEQITQ KGSFYRVSLV
VDGGVALTRA EVERAVALWL NETFQNWTHV VYVDSISSWC RALLVYYHST NESLGGPALS
ARLSAREGLL GGGGLQIVPA SIDVHVVENA AEVASQLAVI TNNELSDEEV SKVVTKVKQL
VNVAEINSSL ASTVVTIISN VMSSSETVLA ASSDKALKTV DELVQKIQFE GPSISISSKH
LAVGISTLNA SVFNGTSFSA FVAPNSTYPQ IDFQSGRSNP LAQVSLPASL LSGTSLTEEE
RSSLSRINFM FFSSTNLFQK EQDGRSLNSY VVASSVGNLS IRDLKDPVEI QIAHLSEHTH
LNPVCMFWDF SMSGGAGGWN ADGCRTSTES SSNRTVCLCD HLTHFGILMD ISRASPHIDQ
ENNRILTFIS YVGCGISAIF SAATLLTYVA FEKLRRDYPS KILMNLSTSL LCLNMVFLLD
GWLASLDTHW LCMSVAIFLH YFLLTTFTWM GLESIHMYIA LVKVFNTYIR RYILKFCLVG
WAGLPAVLVG LVVVVDQTSY GLQQYSGGHS GDGSSQFCWI QNPVVFYTSC VGYFCLVFLL
NVAMFIVVML QICRNGKRSN RTLREEVLRN LRSVVSLSFL LGMTWGFALF AWGPVSLAFM
YLFAIFNSLQ GLFIFVFHCA LKENVQKQWR RFLCCGRFRP SDYSDGSKTP TNNTKKVSSD
QLGKSLSSGS FGSTTASWTS KAKATLNPFT KRHSNTDKCY SNQTGPQCVS SCSSSSEAEP
HSSSSSSSSI LPVSQMIDKV RGYCSTRSDN FYKNIIMSDS FAHSTKF
//
