ID G3PQ47_GASAC Unreviewed; 651 AA.
AC G3PQ47;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 54.
DE RecName: Full=Tetratricopeptide repeat protein 30 {ECO:0000256|RuleBase:RU367070};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000019732.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000019732.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000019732.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- FUNCTION: Required for polyglutamylation of axonemal tubulin. Plays a
CC role in anterograde intraflagellar transport (IFT), the process by
CC which cilia precursors are transported from the base of the cilium to
CC the site of their incorporation at the tip.
CC {ECO:0000256|RuleBase:RU367070}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC {ECO:0000256|ARBA:ARBA00004138, ECO:0000256|RuleBase:RU367070}.
CC -!- SIMILARITY: Belongs to the TTC30/dfy-1/fleer family.
CC {ECO:0000256|ARBA:ARBA00009522, ECO:0000256|RuleBase:RU367070}.
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DR AlphaFoldDB; G3PQ47; -.
DR STRING; 69293.ENSGACP00000019732; -.
DR Ensembl; ENSGACT00000019770.1; ENSGACP00000019732.1; ENSGACG00000014954.1.
DR eggNOG; KOG4340; Eukaryota.
DR GeneTree; ENSGT00390000010116; -.
DR InParanoid; G3PQ47; -.
DR OMA; CCKHELY; -.
DR TreeFam; TF314592; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000014954; Expressed in mesonephros and 12 other cell types or tissues.
DR GO; GO:0005879; C:axonemal microtubule; IEA:UniProtKB-UniRule.
DR GO; GO:0031514; C:motile cilium; IEA:Ensembl.
DR GO; GO:0070738; F:tubulin-glycine ligase activity; IEA:Ensembl.
DR GO; GO:0060271; P:cilium assembly; IEA:Ensembl.
DR GO; GO:0007368; P:determination of left/right symmetry; IEA:Ensembl.
DR GO; GO:0001736; P:establishment of planar polarity; IEA:Ensembl.
DR GO; GO:0042073; P:intraciliary transport; IEA:UniProtKB-UniRule.
DR GO; GO:0036372; P:opsin transport; IEA:Ensembl.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR039941; TT30.
DR PANTHER; PTHR20931:SF0; TETRATRICOPEPTIDE REPEAT PROTEIN 30; 1.
DR PANTHER; PTHR20931; UNCHARACTERIZED; 1.
DR Pfam; PF13174; TPR_6; 1.
DR SMART; SM00028; TPR; 4.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50005; TPR; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273,
KW ECO:0000256|RuleBase:RU367070};
KW Cilium {ECO:0000256|ARBA:ARBA00023069, ECO:0000256|RuleBase:RU367070};
KW Cilium biogenesis/degradation {ECO:0000256|ARBA:ARBA00022794,
KW ECO:0000256|RuleBase:RU367070};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339,
KW ECO:0000256|RuleBase:RU367070}.
FT REPEAT 42..75
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ SEQUENCE 651 AA; 74589 MW; 0E173480C2A6F097 CRC64;
EAMTAIKDGE YTATIYKLIK DSQYVAAIQI LNGQLHKHTK SRAALSLLGY CYFHIQDFTN
SADCYEQLTQ LHPEVEEYKV YYAQSLYKAG AYPEATKASF VLDNPGSHVK MLKLQACIKY
CEEDYSAAKS LLEQLPQEDP DYVYNSGCLL FQDGKYEEAC KKFSSAMQVL GYVPALSYNI
ALCFYSLKNY PQAIKYIGEI IDQGMREHPE LSVGLTTDGI DVHSVGNTLV LHQTALIEAF
NLRAAIEYQL KNVKGAQEAL TDMPPRSEEG ADPVTLHNQA LVNMDTKPSE GFEKLAFLLL
QPSFPPVTFG NLLLLYCKHE YFDLAADVLA ENAHLTYKLL SPYMYEFLDA LLTCQTAPEE
AFRKFDEMNG KLTEQLRKLA KQVQEARMSR DDDGQKKALQ ENDQTQEKWY IVVLMAQAKI
YWNRENFQMV EKIFRKSVEV CNDDDTWKLN VAHVLFMQAK YKDAIGFYEP IVKKHYDNIL
NVSAVVLANL CVSYILTSQN EEAEELMRKI EKEEEQISYD DPEKKVFHLC IVNLVIGTLY
CAKGNYEFGI SRVIKSLEPY NKKLGTDTWF YAKRCFLSLL ENMSKHMVML KDAVVQECIQ
FLEHCEAYGR EVPAVIEQPL EETRVHVGKN TVTYEARLLK ALFYEVIGWN K
//