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Database: UniProt
Entry: G3PRS3_GASAC
LinkDB: G3PRS3_GASAC
Original site: G3PRS3_GASAC 
ID   G3PRS3_GASAC            Unreviewed;       836 AA.
AC   G3PRS3;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   30-AUG-2017, entry version 23.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000020309, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000020309}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000020309}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSGACP00000020309}.
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DR   Ensembl; ENSGACT00000020348; ENSGACP00000020309; ENSGACG00000015401.
DR   GeneTree; ENSGT00390000004941; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007635};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    404    428       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    448    467       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    538    559       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    565    589       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    638    660       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    740    763       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    769    792       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED      100    127       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   836 AA;  95292 MW;  A4982BF7459EE76B CRC64;
     WSEGHVMGEL FRSEEMTLAQ LFLQSEAAYC CVSELGELGM VQFRDLNPDV NVFQRKFVNE
     VRRCEEMDRK LRFVEKEIKK AIIPTVDTGE NPEVPFPRDM IDLEATFEKL ENELKEINTN
     QEALKKNFLE LTELKHILRR TQQFFDEQTH RREHNSCVIH SEPSRFGRSR FVAGVIGRER
     IPTFERMLWR VCRGNVFLRK AEIEDPLEDP ATGDQVHKSV FIIFFQGDQL KNRVKKICEG
     FRASLYPCPE TPQERKEMLA GVNSRIDDLQ MVLNQTEDHR QRVLQAASKT MRVWFIKVRK
     MKAIYHTLNL CNIDVTQKCL IAEVWCPVSD LDSIQFALRR GTERSGSTVP SILNRMQTKQ
     TPPTFNKTNK FTSGFQNIVD AYGIGNYREI NPVKAPYTII TFPFLFAVMF GDMGHGVLMT
     CIALYLVIRE SRLVAQKSDN EMFNMVFAGR YIILLMGLFS MYTGIIYNDC FSKSLNMFGS
     GWSVRPIFET LNGNGVLQLD PAVPGVFNGP YPLGIDPIWN VATNKLTFLN SFKMKMSVIL
     GVIHMLFGVS LSLFNHLYFK KPLNIFLGFI PEIVFMASLF GYLALLVFYK WTAYDVFTSK
     DAPSLLIHFI NMCLFNYSDP TSKPLYRGQV LPPSAMGIQI LLVLIALACV PCMLIVKTMV
     LRLQSKKREE TPAENLEQSL EQTGVSSSCT GLTQQGTQKF GGHSEEGEEF DFGDVAVHQA
     IHTIEYCLGC ISNTASYLRL WALSLAHAQL SEVLWTMVMH LGLSSRSGGG FFALSIIFSA
     FATLTVAILL VMEGLSAFLH ALRLHWVEFQ NKFYCGQGFK FLPFSFESIL EGRFDE
//
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