ID G3PUF0_GASAC Unreviewed; 1031 AA.
AC G3PUF0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=SUMO-activating enzyme subunit 1 {ECO:0000256|ARBA:ARBA00044187};
DE AltName: Full=Ubiquitin-like 1-activating enzyme E1A {ECO:0000256|ARBA:ARBA00044354};
GN Name=UBA6 {ECO:0000313|Ensembl:ENSGACP00000021237.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000021237.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000021237.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000021237.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein sumoylation.
CC {ECO:0000256|ARBA:ARBA00004718}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBUNIT: Heterodimer of SAE1 and UBA2/SAE2. The heterodimer corresponds
CC to the two domains that are encoded on a single polypeptide chain in
CC ubiquitin-activating enzyme E1. Interacts with UBE2I.
CC {ECO:0000256|ARBA:ARBA00026003}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ubiquitin-activating E1 family.
CC {ECO:0000256|ARBA:ARBA00005673}.
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DR AlphaFoldDB; G3PUF0; -.
DR STRING; 69293.ENSGACP00000021237; -.
DR Ensembl; ENSGACT00000021278.1; ENSGACP00000021237.1; ENSGACG00000016096.1.
DR eggNOG; KOG2012; Eukaryota.
DR GeneTree; ENSGT00940000158826; -.
DR InParanoid; G3PUF0; -.
DR OMA; WSHCVEL; -.
DR TreeFam; TF300586; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000016096; Expressed in liver and 13 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd01491; Ube1_repeat1; 1.
DR CDD; cd01490; Ube1_repeat2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 2.40.30.180; Ubiquitin-activating enzyme E1, FCCH domain; 1.
DR Gene3D; 3.50.50.80; Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1; 1.
DR Gene3D; 3.40.50.12550; Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2; 1.
DR Gene3D; 1.10.10.2660; Ubiquitin-activating enzyme E1, SCCH domain; 1.
DR Gene3D; 3.10.290.60; Ubiquitin-activating enzyme E1, UFD domain; 1.
DR InterPro; IPR032420; E1_4HB.
DR InterPro; IPR032418; E1_FCCH.
DR InterPro; IPR042302; E1_FCCH_sf.
DR InterPro; IPR045886; ThiF/MoeB/HesA.
DR InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR InterPro; IPR018965; Ub-activating_enz_E1_C.
DR InterPro; IPR042449; Ub-E1_IAD_1.
DR InterPro; IPR038252; UBA_E1_C_sf.
DR InterPro; IPR019572; UBA_E1_SCCH.
DR InterPro; IPR042063; Ubi_acti_E1_SCCH.
DR InterPro; IPR035985; Ubiquitin-activating_enz.
DR InterPro; IPR018075; UBQ-activ_enz_E1.
DR InterPro; IPR000011; UBQ/SUMO-activ_enz_E1-like.
DR NCBIfam; TIGR01408; Ube1; 1.
DR PANTHER; PTHR10953:SF162; SUMO-ACTIVATING ENZYME SUBUNIT 1; 1.
DR PANTHER; PTHR10953; UBIQUITIN-ACTIVATING ENZYME E1; 1.
DR Pfam; PF16191; E1_4HB; 1.
DR Pfam; PF16190; E1_FCCH; 1.
DR Pfam; PF09358; E1_UFD; 1.
DR Pfam; PF00899; ThiF; 2.
DR Pfam; PF10585; UBA_E1_SCCH; 1.
DR PRINTS; PR01849; UBIQUITINACT.
DR SMART; SM00985; UBA_e1_C; 1.
DR SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 2.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 899..1021
FT /note="Ubiquitin-activating enzyme E1 C-terminal"
FT /evidence="ECO:0000259|SMART:SM00985"
SQ SEQUENCE 1031 AA; 115518 MW; 4CB5D8AC996AD087 CRC64;
PSMAADSMEI DDSLYSRQRY VLGDSAMHQM AQSSVFLSGM GGLGIEIAKN IVLAGVKAVT
LHDTKRCETW DLGSNFFIHN EDVSTQKRRW RPRVEAVCPR VAELNPYVHV DVSSEALDDN
NDLGFLGKYQ CVILTEARLS LQKRVNDFCH FHQPPIRFIG CDAYGICARV FCDFGEEFEV
SDPTGEEPKE IFIQSITQGD RGVVTCMDNQ PHGLQTGQSV VFREVNGMVE VNGTARPIAV
VLSPHSFEIG DTSQFQPYQH GGFFVLVKTP KTYRFETLER QLCDPHVLTP DFSKPEAPLQ
IHAAMLALDA FQEQHSRLPN TGCSQDAEVL LKLNEEVNQT LRNKASVNVE LVRCLSRTAR
GTLPPLAAAV GGLASQEVLK AITGKFAPLQ QWFYLDAVEV VRPLQSVAAE EFLPRGDRYD
GLRACIGEPM CVALHKLRVF MVGCGAIGCE MLKNFALLGV GLTSSSGEVC ITDPDLIEKS
NLNRQFLFRP RHIQKPKSTT AAEATLEINP DLQVDAHLNK VCPATESVYN DAFYSRVNLV
VTALDSVEAR RYVDSRCLSN QRPLLDSGTM GTKGHTEIIV PNLTESYNSH RDPPEEEIPF
CTLKSFPSVI EHTIQWARDK FENLFAHKPS MYNSFWQTHP SVEVVLQRMQ MGESLEGSFQ
VIKLLSKRPS RWDQCIAIGR LKFEKYFKRK ALQLLHSFPL DTRLKDGSLF WQSPKRPPAP
IDFDLRDSLH FSFIVSTARL FAGIYNIPYS PKDVTEEEVT RLLSDVKIPE YRPSEKCIET
DETAKKPDSV KLPLSSEEER EAIAQLEHAI ATDNVTQSGC RWSPLQFEKD DDLNGHMDFV
TAASALRARM YAIEPADRLK TKRIAGKIIP AIATATAAVA GLVALELVKV VGGYEFELFK
NCFFNLAIPV VVLTEPAPVK QSLIRDNIYF SIWDCWSVFG HEDFTLSDFI NAVREKYGIE
PTMVVHGVKM LYVPVMPGHS KRLKLTMQKL IKPSGDRRYV DLTVSFAPET DGDDDLAGPP
VRYFFSRNGE T
//
