ID G3PVE3_GASAC Unreviewed; 1435 AA.
AC G3PVE3;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 79.
DE SubName: Full=ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 {ECO:0000313|Ensembl:ENSGACP00000021580.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000021580.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000021580.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000021580.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR STRING; 69293.ENSGACP00000021580; -.
DR Ensembl; ENSGACT00000021621.1; ENSGACP00000021580.1; ENSGACG00000016344.1.
DR eggNOG; KOG1117; Eukaryota.
DR GeneTree; ENSGT00940000158869; -.
DR InParanoid; G3PVE3; -.
DR OMA; CETVFQS; -.
DR TreeFam; TF105769; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000016344; Expressed in heart and 7 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IEA:InterPro.
DR GO; GO:0001946; P:lymphangiogenesis; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd17228; RA_ARAP3; 1.
DR CDD; cd04385; RhoGAP_ARAP; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 5.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR037858; RhoGAP_ARAP.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45899:SF4; ARF-GAP WITH RHO-GAP DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 3; 1.
DR PANTHER; PTHR45899; RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00169; PH; 4.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00536; SAM_1; 1.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 5.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 5.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 5.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Signal {ECO:0000256|SAM:SignalP};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1435
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003450150"
FT DOMAIN 8..68
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 303..395
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 410..499
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 496..631
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT DOMAIN 689..803
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 814..912
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 916..1097
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 1126..1220
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 1233..1336
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 69..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 71..95
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..142
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1435 AA; 163452 MW; F2CA040E22210DFE CRC64;
HAADLSVSVL LWLFLFFDSR YLDTFHGAGL LSARDFTHLD NDAFVSLGIT ATGHRKRILR
LVRHLQRMES QRANQKANPP RDRCQSVSDV SSSQRAHVKP VPKPRTVFNR RRTAPVHFCA
TTDAPPPSTA GSPPPSSRGP HPHPHPPHLH LQLSESPGSP RGGGMEMVSN EIYWGTSPGS
TAPVAGRSYY GQQSAPPTPP RQTPERNRIH QDILRLCRGI PPRGRPLFPM VGEILLKPQK
FSWTKCLSQA LHSGDSQGYS TVGEPPHPAR YLSLPTHSFS PEADEDLTIS PYASYASLTE
RSLPIISSWL DKLSPQGNYV FQKRYVKFDG KNLMYFGSEK DVYAKGVIPL AAIQMARPAK
DNKFEVVTSH RIFVFRTDNE ALRRRWVGTL QEHVRDQLVF GQRPFGPGSH CQRHGVLELK
GTKSKVYAAI NTEQIWIYKS EQCFRNRIGI TVIEARGATI RDGKHKSFDL ITPYKKLHFT
AESDREKRDW MEALQEAIAE TLSDYEVAEK IWSNRSNRTC ADCRAPNPDW ASINLCVVIC
KNCAAGQHRG LGTMVSKVQS LKLDTSVWSN EIVQLFIMLG NDRANEFWAA RLPATEELDA
DASPDQRRDF ISQKYREGRY RLPHPGFNSQ EELLKVLCSA VSEQTLLKTV SHIFAEAESV
HFSDASNGCQ RHHHQLESDL SVYDEIMQPV LHSGYLYKSS SVHRGTLSRK TREDFQKFWC
TVDRSLVLYE SDRSSDPCLQ ISVKDIVCLG VSRPDSSNNS SGFIDRFRYT FELYLTSEKL
YQFGLETANV LHSWTQSIGK ASTPLSCHCL LTREFERVGL LRYRAMLDPQ RWKEAFFVLQ
KSNLFICPRT DGAAEDIINL NCLQELSVTF ETENHEKKDI LVLVEKGRTL HLQGVGRMDF
SLWYSDIQRA AGGKGNALRE QQLSRNDIPI IVDSCLAFIT QYGLGHEGIY RKNGANSRIK
LLMEEFRKDA RNVKLRIGDH FIEDVTDVLK RFFREVEDPV FMADLHSLWQ GAAKIPQKGQ
GLDRYKEIIQ SFPGVNRPTL AAVFGPLYRV QKCADLNQMC TKNLSLLFAP SLFQTDGKGE
HEVKIIEDLI DNYLYLFDID EEHQTQIELE ISLITTWKDT QLSQAGDLII EVYLEKKTPD
CCITLKVSPT MSAEELTNQV LFMRNVPAGD KDLWMTFEAM EDGQLERPLH PKERVLEQAL
QWCKMADPSS AYLVVKRVPK GEGITLLTSY KSEIMKIGLL RCREEPPKLL QGNKFQERTF
QIINHKLLLL KDKKSIKPEK EWSLKSMKIY IGIRRKLKAP TRWGFTVMSH KHQLFLCCSC
EDDMWDWITS FLKAQNDDPG PPVLRRHLSS DISKHKFGTM PLVPIRGDES NSSMLSANQT
LRKLHDRRTL SMYFPMKVQK DSFEERSQSP GLPEPLYEEV GDFGLQVLKS LETSF
//