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Database: UniProt
Entry: G3PVE3_GASAC
LinkDB: G3PVE3_GASAC
Original site: G3PVE3_GASAC 
ID   G3PVE3_GASAC            Unreviewed;      1435 AA.
AC   G3PVE3;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   24-JAN-2024, entry version 79.
DE   SubName: Full=ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 {ECO:0000313|Ensembl:ENSGACP00000021580.1};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000021580.1, ECO:0000313|Proteomes:UP000007635};
RN   [1] {ECO:0000313|Ensembl:ENSGACP00000021580.1, ECO:0000313|Proteomes:UP000007635}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGACP00000021580.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   STRING; 69293.ENSGACP00000021580; -.
DR   Ensembl; ENSGACT00000021621.1; ENSGACP00000021580.1; ENSGACG00000016344.1.
DR   eggNOG; KOG1117; Eukaryota.
DR   GeneTree; ENSGT00940000158869; -.
DR   InParanoid; G3PVE3; -.
DR   OMA; CETVFQS; -.
DR   TreeFam; TF105769; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   Bgee; ENSGACG00000016344; Expressed in heart and 7 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IEA:InterPro.
DR   GO; GO:0001946; P:lymphangiogenesis; IEA:Ensembl.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd17228; RA_ARAP3; 1.
DR   CDD; cd04385; RhoGAP_ARAP; 1.
DR   Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 5.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR   InterPro; IPR037278; ARFGAP/RecO.
DR   InterPro; IPR001164; ArfGAP_dom.
DR   InterPro; IPR038508; ArfGAP_dom_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR037858; RhoGAP_ARAP.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR45899:SF4; ARF-GAP WITH RHO-GAP DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 3; 1.
DR   PANTHER; PTHR45899; RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C; 1.
DR   Pfam; PF01412; ArfGap; 1.
DR   Pfam; PF00169; PH; 4.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   Pfam; PF00536; SAM_1; 1.
DR   SMART; SM00105; ArfGap; 1.
DR   SMART; SM00233; PH; 5.
DR   SMART; SM00324; RhoGAP; 1.
DR   SMART; SM00454; SAM; 1.
DR   SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF50729; PH domain-like; 5.
DR   SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS50115; ARFGAP; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 5.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
DR   PROSITE; PS50105; SAM_DOMAIN; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..1435
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003450150"
FT   DOMAIN          8..68
FT                   /note="SAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50105"
FT   DOMAIN          303..395
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          410..499
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          496..631
FT                   /note="Arf-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50115"
FT   DOMAIN          689..803
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          814..912
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          916..1097
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   DOMAIN          1126..1220
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000259|PROSITE:PS50200"
FT   DOMAIN          1233..1336
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          69..166
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        71..95
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        127..142
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1435 AA;  163452 MW;  F2CA040E22210DFE CRC64;
     HAADLSVSVL LWLFLFFDSR YLDTFHGAGL LSARDFTHLD NDAFVSLGIT ATGHRKRILR
     LVRHLQRMES QRANQKANPP RDRCQSVSDV SSSQRAHVKP VPKPRTVFNR RRTAPVHFCA
     TTDAPPPSTA GSPPPSSRGP HPHPHPPHLH LQLSESPGSP RGGGMEMVSN EIYWGTSPGS
     TAPVAGRSYY GQQSAPPTPP RQTPERNRIH QDILRLCRGI PPRGRPLFPM VGEILLKPQK
     FSWTKCLSQA LHSGDSQGYS TVGEPPHPAR YLSLPTHSFS PEADEDLTIS PYASYASLTE
     RSLPIISSWL DKLSPQGNYV FQKRYVKFDG KNLMYFGSEK DVYAKGVIPL AAIQMARPAK
     DNKFEVVTSH RIFVFRTDNE ALRRRWVGTL QEHVRDQLVF GQRPFGPGSH CQRHGVLELK
     GTKSKVYAAI NTEQIWIYKS EQCFRNRIGI TVIEARGATI RDGKHKSFDL ITPYKKLHFT
     AESDREKRDW MEALQEAIAE TLSDYEVAEK IWSNRSNRTC ADCRAPNPDW ASINLCVVIC
     KNCAAGQHRG LGTMVSKVQS LKLDTSVWSN EIVQLFIMLG NDRANEFWAA RLPATEELDA
     DASPDQRRDF ISQKYREGRY RLPHPGFNSQ EELLKVLCSA VSEQTLLKTV SHIFAEAESV
     HFSDASNGCQ RHHHQLESDL SVYDEIMQPV LHSGYLYKSS SVHRGTLSRK TREDFQKFWC
     TVDRSLVLYE SDRSSDPCLQ ISVKDIVCLG VSRPDSSNNS SGFIDRFRYT FELYLTSEKL
     YQFGLETANV LHSWTQSIGK ASTPLSCHCL LTREFERVGL LRYRAMLDPQ RWKEAFFVLQ
     KSNLFICPRT DGAAEDIINL NCLQELSVTF ETENHEKKDI LVLVEKGRTL HLQGVGRMDF
     SLWYSDIQRA AGGKGNALRE QQLSRNDIPI IVDSCLAFIT QYGLGHEGIY RKNGANSRIK
     LLMEEFRKDA RNVKLRIGDH FIEDVTDVLK RFFREVEDPV FMADLHSLWQ GAAKIPQKGQ
     GLDRYKEIIQ SFPGVNRPTL AAVFGPLYRV QKCADLNQMC TKNLSLLFAP SLFQTDGKGE
     HEVKIIEDLI DNYLYLFDID EEHQTQIELE ISLITTWKDT QLSQAGDLII EVYLEKKTPD
     CCITLKVSPT MSAEELTNQV LFMRNVPAGD KDLWMTFEAM EDGQLERPLH PKERVLEQAL
     QWCKMADPSS AYLVVKRVPK GEGITLLTSY KSEIMKIGLL RCREEPPKLL QGNKFQERTF
     QIINHKLLLL KDKKSIKPEK EWSLKSMKIY IGIRRKLKAP TRWGFTVMSH KHQLFLCCSC
     EDDMWDWITS FLKAQNDDPG PPVLRRHLSS DISKHKFGTM PLVPIRGDES NSSMLSANQT
     LRKLHDRRTL SMYFPMKVQK DSFEERSQSP GLPEPLYEEV GDFGLQVLKS LETSF
//
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