ID G3PVS5_GASAC Unreviewed; 2149 AA.
AC G3PVS5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Myosin VIIBb {ECO:0000313|Ensembl:ENSGACP00000021714.1};
OS Gasterosteus aculeatus (Three-spined stickleback).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC Gasterosteus.
OX NCBI_TaxID=69293 {ECO:0000313|Ensembl:ENSGACP00000021714.1, ECO:0000313|Proteomes:UP000007635};
RN [1] {ECO:0000313|Ensembl:ENSGACP00000021714.1, ECO:0000313|Proteomes:UP000007635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lindblad-Toh K., Mauceli E., Grabherr M., Chang J.L., Lander E.S.;
RL Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGACP00000021714.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR STRING; 69293.ENSGACP00000021714; -.
DR Ensembl; ENSGACT00000021755.1; ENSGACP00000021714.1; ENSGACG00000016439.1.
DR eggNOG; KOG4229; Eukaryota.
DR GeneTree; ENSGT00940000157247; -.
DR InParanoid; G3PVS5; -.
DR OMA; CCEAICK; -.
DR TreeFam; TF335306; -.
DR Proteomes; UP000007635; Unassembled WGS sequence.
DR Bgee; ENSGACG00000016439; Expressed in intestinal epithelial cell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd17092; FERM1_F1_Myosin-VII; 1.
DR CDD; cd14473; FERM_B-lobe; 2.
DR CDD; cd13198; FERM_C1_MyoVII; 1.
DR CDD; cd13199; FERM_C2_MyoVII; 1.
DR CDD; cd01381; MYSc_Myo7; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 2.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 1.20.80.10; -; 2.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR041793; MyoVII_FERM_C1.
DR InterPro; IPR041794; MyoVII_FERM_C2.
DR InterPro; IPR036106; MYSc_Myo7.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR22692; MYOSIN VII, XV; 1.
DR PANTHER; PTHR22692:SF24; UNCONVENTIONAL MYOSIN-VIIB ISOFORM X1; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00612; IQ; 3.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF00784; MyTH4; 2.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00295; B41; 2.
DR SMART; SM00015; IQ; 4.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00139; MyTH4; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 2.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR PROSITE; PS50057; FERM_3; 2.
DR PROSITE; PS50096; IQ; 2.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51016; MYTH4; 2.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000007635};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 61..741
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1008..1229
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1234..1542
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 1677..1831
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1837..2138
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 618..640
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 901..987
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 906..920
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 938..972
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 973..987
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 154..161
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 2149 AA; 244438 MW; D0284A9B9F57EA9E CRC64;
LVMLRKGEWV WVDSDIGVPI GAKVKVTKSG RRLLVDDDGK EKSLSQEQEA SLKIMHPTSV
EGVDDMIKLG DMNEAGLLRN LLLRHKRDII YTYTGSVLVA VNPYQAYPLY SVDQVQMYHG
RQLGELPPHI YAIAESAYGN MTRNLRNQCC IISGESGAGK TESTKLILQY LAAVSGELSH
QQIEEQILQS NPILEAFGNA KTIRNDNSSR FGKYLEIFFN KDGVIEGARV EQYLLEKSRV
CHQAPHERNY HMFYCMLAGV TAEEKKTLSL GDAKEYTFLS KGDTVDCEGR DDAKDYKIIC
SAMKVLTFSE SQCQEILKLL AAILHLGNIC FEANTQNNLE TSEVSKSQHF SIAASILEVR
KSSLASSLTH RSFMTNRERV TKPLSAEQAS DSRDAFVKAI YNKLFVWIVG KINNVIYKKL
ANNPKSSFLS IGLLDIFGFE NFKTNSFQQS VARLAAKKKT DVVLRHIFKL EQKEYRKEDI
VWNKIRFSDN QNILDVLAVK PCNLLALIDE ESHFPKGSDL TMLNKMNQQH SGNKTYIASK
SEHHTDFGIR HFAGVVHYDS KGFLEKNRDA VSFDIIKMVD LTTNKLLHQI FETELSTNAQ
SDSRKQVTTL SAQFRQSLDS LMKALSACQP FFIRCFKPNN EKQSKVFDRE LCMRQLRYSG
MMDTIRIRKL GYPIRHTFVE FLHRYRVLLK TTVCDPKTET AAACCEAICQ TAIEGADEWK
IGRTKIFLRD AHDAVLERLR EQRLGKIALV IQRVMLGHKD RKSFLKKRRA AVVLQKNWRA
YKQEKILLNQ IQKGFERLVS KIRSRKLRLQ HLRQREAALT IQSQVRGYRE RKGWKQKREA
VILLQACSRG LLARRIAEKK RKDLLFTQTP SQASLLLLAK ENQQKIASEL QQRLAAIARL
QPAHQEPEPI VERDSEDDAS DLQPTPPVEV IKPESPPSNG FQKRNVPTPV EETSVETSEQ
KIVTAASSTP TPSVEEEEED DEFDEGSDEF SFNAFSSLHF QGNADHTHFN QRLRQPLLHH
DDEGDALACL TIWWIILRYM GDMPEPRPVD ATSQSSTIAS RQLPQRQGRR LSSLVGLDQK
IMRKNKKKLG GGSRKASMIP EEPENFTEED NILIGEGPTL DRPLSSLEKL QFIIGYALSR
PNIRDEIYCQ ICKQLVNNKN RRSRMQGWIL LSICLGIFPP SEVFMKYLER FVRRGPDGYG
KYCAERLTRT AANSARKELP CWTEEQAAKS KKPIDVAVTI EDDRAIRLQV DSASTSAEVC
QAVADQIGLR DTYGFSLYIS FNEKMWSLGS SGRHVFDAVS QCEQEMRRQG KKEKDAPWRL
SIRKELFTPW HDTSVDPIST DLIYRQVIKG IKMGEYTSDN DNDYVHLGAQ NYYIQFGSAC
NKDNVGKVVE ECISTTLLEK KSKTKWIELI NTAHMEGPYI NGNQTSDSVK GELVSNAQHA
WPLHFSKFFE ATLISGPSLL KSRFFVAVNS SGVFFMDGRD KSLLQIPYLE VKDVRIINDS
HFSDTGSLSL ATVKGEFVLT SADAVEMAAL IEKNLDGLRR RSVYALAQQD VGKPASADDP
AFLLCKRGDL LLVKDRSGFP DNNVMKVTNQ RTGAECAVHK DTVQFLPTLE KPTDVMLELL
CPGQRKQSTA QNNNLRNDTV APISLKEFAF DYFRPAAKDA GRHGAGKVVV RERLWACSRE
PLKQPLLKSL LGNSDLSNLA CSIFTDILGT NASEYMGDYP IKHARSPLEL TDQIFGPATQ
HEALQDEVYC QIMRQMTNNP SRLSMERGWQ LMWLCLGLFR PSPNLQKHTQ HFLESRPRDQ
LAPGCLKRLH QMSRKEPRKL PPHPVEVDAI QQNSTQIFHK IHFPNDTSDI FEVKSTSTIE
TLCRSIAIKL KVSSAEGYGL YLKTPNKLVS MEEQNYFFDS LRQTSEAPKK AKKVKEGNPA
MAPYRVIFKR KLWFNVSPGK DLVADLTFHF PQELPRYLRG YHNCTKEDMT NLGGLLFRVE
VDSDRSQFVM IPRMLRELVP ADQLKIMSPE EWKKHIVSAY NRQSGITVQE AKIAFLKDIS
SWPTFGCSFF EVKQTCDSSY PNTVLISISK QGVCLIDPVT KELLVMHPFS RITEYQSDSG
YFEMTIGTMG NIFVCETTQA HTMEDLLRSY ITMYERQRQN FRPRNQMFS
//
